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Investigating the Effect of Genetic Polymorphisms of Deiodinase Type 2 on Levothyroxine Dose Requirements in Patients with Hypothyroidism
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Background: Hypothyroidism is the most abundant thyroid disorder worldwide. For decades, levothyroxine was the main effective pharmacological treatment for hypothyroidism. A variety of factors can influence levothyroxine dose, such as genetic variations. Studying the impact of genetic polymorphisms on the administration of medications was risen remarkably. Different genetic variations were investigated that might affect levothyroxine dose requirements, especially the deiodinase enzymes.  Deiodinase type 2 genetic polymorphisms’ impact on levothyroxine dose was studied in different populations. Objective: To examine the association of the two single nucleotide polymorphism (SNP)s of deiodinase type 2 (rs225013 and rs225014) and levothyroxine dose requirements. Subjects and Methods: A cross-sectional study was conducted at Baghdad Center for Nuclear Medicine and Radiation Therapy located in Baghdad/ Iraq, from March to June 2022. Based on levothyroxine dose, the enrolled patients were divided into two groups: low dose group < 1.7 µg/kg/day and high dose group ≥ 1.7 µg/kg. Then genotyping analysis was done for both groups of the study. Results: The mean age of the participants was 40.35 ± 9.5 years with a mean body mass index of 30.61 ± 5.72 kg/m2. The mean levothyroxine doses in the low- and high-dose groups were 81.67 ± 30.74 µg/day and 161.67 ± 35.19 µg/day, respectively. Significant differences existed in the levels of TSH and TT4 between the study’s groups. Conclusion: This study indicated that the differences in levothyroxine dose, TSH, TT4 and TT3 levels were not associated with the DIO2 rs225013. Similarly, the differences in TSH, TT3 and TT4 levels revealed a non-significant association with DIO2 rs225014 except for levothyroxine dose which was higher in the patients who carried the wild type allele (TT).

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Publication Date
Wed Dec 01 2010
Journal Name
Baghdad Science Journal
Relation between Body Iron Store and Insulin Resistance in Type 2 Diabetes
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The clinical impact of interaction between body iron status (serum iron and ferritin) and type 2 diabetes has been investigated in this study. Thirty-six females were enrolled, eighteen type 2 diabetes and eighteen apparently healthy. These two groups were matched for age and body mass index BMI. The eighteen diabetes females were matched for age, BMI, pharmacological treatment (oral hypoglycemic agent), and chronic diabetes complications. The biochemical parameters measured for both groups (control and diabetes patient) were fasting insulin (Io), fasting blood glucose (Go), serum iron and ferritin. A significant increase in all parameters in patients compared to healthy control was noticed. The insulin resistance (IR) which was calculat

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Publication Date
Tue Sep 29 2020
Journal Name
Iraqi Journal Of Science
Irisin Levels Related to Glycosylated Hemoglobin in Type 2 Diabetic Obese Women
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The aim of the preset study is to explain the role of irisin hormone levels in type-2 obese diabetic women and compare these levels with those in obese nondiabetic women. In addition, we investigated the relation of irisin levels with those of glycated hemoglobin (HbA1c) and body mass index (BMI) in the patients.

Eighty eight subjects were included in this study, including 44 type-2 Iraqi obese diabetic women as a patients group, and 44 obese nondiabetic women as a control group. Serum irisin was measured by Enzyme-linked Immune-Sorbent assay (ELISA), while determination of glycosylated Hemoglobin was carried out by The SD A1c CareTM system. Diabetic type-2 obese women showed a highly significant decrease in

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Scopus Crossref
Publication Date
Mon May 22 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
A Theoretical Study of the Effect of The Solvent Type on The Reorganization Energies of Dye - Semiconductor System Interface
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    A theoretical calculation of the reorganization energies is demonstrated for semiconductor (TiOâ‚‚, ZnO) and organic dye (safranine T, and coumarin) with a variety solvent such that (water,  1­propanol, Formamide, Acetonitrile and Ethanol).     The reorganization energy values for dye –semiconductor interface system are large in high polar solvent (water 741 .0  , Acetonitrile 708 .0  , Ethanol 669 .0  ) and small in low polar solvent(1­propanol 635 .0  . The reorganization energy in safranine T –semiconductor system is larger ( 635 741.0  )than in coumarin –semiconductor for with the same solvents ( 612

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Publication Date
Mon May 14 2018
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Urinary Vitamin-D Binding Protein as an Early Predictor of Diabetic Nephropathyin Type 1 and Type 2 Diabetes
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    Diabetic nephropathy (DN) is the most common microvascular complication that may lead to chronic renal failure in diabetic patients. Till now microalbuminuria, with its restrictions, is the early marker of DN, appeared after the disease exacerbation. Thus, new biomarkers are required to predict the early onset of DN before the appearance of microalbuminuria. The aim of this study is to investigate the possible use of uVDBP in the early prediction of DN. Fifty diabetic patients with DN and 40 diabetic patients without DN for both types of diabetes were enrolled in this study. All patients were tested for uACR, uVDBP (measured by ELISA), and blood HbA1c. The results demonstrated a highly significant elevation of uAC

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Crossref
Publication Date
Wed Apr 01 2009
Journal Name
Journal Of The Faculty Of Medicine Baghdad
The role of Chloroquine phosphate on rheumatoid factor in patients with knee osteoarthritis
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Background: Osteoarthritis (OA) is disorder of diarthrodial joints characterized clinically by pain and functional limitation. Rheumatoid factor (RF) represents one of routine laboratory tests that done for all patients have joint complaints. Chloroquine phosphate (CQP) is a disease modifying antirheumatic drug (DMARD) used for patients suffer from knee osteoarthritis (KOA) in order to reduce their RF value and improves the disease status.
Objective: To evaluate the effect of chloroquine phosphate on rheumatoid factor (RF) level in serum of patients with knee osteoarthritis KOA) Design: case report.
Subjects and methods: RF value were assessed quantitatively by ELISA technique before and after tre

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Crossref
Publication Date
Sat Jan 13 2018
Journal Name
Journal Of Engineering
Investigating the Influence of the Cerium loading in prepared Y zeolite from Iraqi kaolin on its Catalytic Performance
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In this study, the effects of different loading doses of cerium in the prepared NaY zeolite from Iraqi kaolin were investigated. Al-Duara  refinery atmospheric residue fluid catalytic cracking was selected as palpation reaction for testing the catalytic activity of cerium loading NaY zeolite.  The insertion of cerium in NaY zeolites has been synthesized by simple ion exchange methods. Three samples of modified zeolite Y have been obtained by replacing the sodium ions in the original sample with cerium and the weight percent added are 0.35, 0.64, and 1.06 respectively. The effects of cerium loading to zeolite Y in different weight percent on the cracking catalysts were studied by employing a laboratory fluidized

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Publication Date
Sun Apr 01 2012
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Effects of high and low dose of cadmium chloride on male Reproductive system in mice
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Background: Cadmium is highly toxic and carcinogenic environmental contaminant exposure to cadmium has been reported to reduce male fertility and there are several hypotheses that suggest how reduced male fertility may result from incorporation of cadmium. The purpose of this study was to determined the role of testicular ascorbic acid level in cadmium mediated oxidative damage on mice testis.
Objectives:To know the extent of toxicity of cadmium chloride and its adverse effects on male reproductive system in mice .
Methods:Fifteen adult albino male mice were divided into three groups, group one control and two experimental groups (low dose and high dose ).the experimental groups were injected with sing

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Publication Date
Wed Apr 01 2020
Journal Name
Indian Journal Of Forensic Medicine & Toxicology
Hormonal and mineral imbalance effect on bone resorption in predialysis iraqi patients with chronic kidney disease
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Scopus
Publication Date
Sun Jan 03 2010
Journal Name
Journal Of The Faculty Of Medicine Baghdad
The Effect of Chronic liver diseases on homocysteine and vitamin B12 in patients serum
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Background: Homocysteine (Hcy) is a sulfur containing amino acid that is formed as an intermediary in methionine metabolism. Raised plasma homocysteine levels, which may contribute
to the increased risk of chronic liver disease.
Patients and Methods: Sixty two patients with chronic liver disease and 26 healthy individuals were included as normal controls for the study. The HPLC system was used for the determination of Hcy and vitamin B12.
Results: A highly significant Hcy concentrations were noted in all patients with cirrhosis, chronic hepatitis or liver mass. There was a trendency towards higher Hcy concentrations in more advanced stages of liver disease. The study showed that the concentrations of tot

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Crossref
Publication Date
Sun Jan 05 2014
Journal Name
Journal Of Educational And Psychological Researches
The requirements of curriculum development for the public stage in Iraq
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 Chapter One : the importance of research and the need for it .
       He has developed the concept of the curriculum has evolved as other educational concepts . Because the world has become a small village due to modern technology and are used in various aspects of life , and the rapid communication between the world can be accessed easily and conveniently . And that the purpose of education citizens who create social functions which ones to keep the culture , upgrade and repair flaws, and aims to develop the capacity of the individual and the preparations in the footsteps of scientific and technological development .
- The goal of research : The research aims to:
1 . What is the

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