Review of interleukin-6 polymorphisms in rheumatoid arthritis: a genetic implications

Dhulfiqar Nidhal Alhilali; Samer Imad Mohammed; Faiq Isho Gorial

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Publication Date

Thu Jan 02 2025

Journal Name

Journal Of Advanced Pharmacy Education And Research

Volume

15

Issue Number

1-2025

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Review of interleukin-6 polymorphisms in rheumatoid arthritis: a genetic implications

Rheumatoid arthritis

Interleukin-6

Genetics

Polymorphism

Pharmacogenetics

Dhulfiqar Nidhal Alhilali

Samer Imad Mohammed

Faiq Isho Gorial

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The objective review is to inspect the involvement of Interleukin-6 (IL-6) in rheumatoid arthritis (RA) and to highlight the role of IL-6 and its variants in the pathogenesis of RA and response to anti-IL-6 agents. Several genetic and environmental risk factors and infectious agents contributed to the development of RA. Interleukin-6 is engaged in self-targeted immunity by modifying the equilibrium between T regulatory (T-reg) and T helper-17 (Th-17) cells. The evidences reported that IL-6 parti

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Publication Date

Thu Jun 30 2022

Journal Name

Journal Of Economics And Administrative Sciences

Using Genetic Algorithm to Estimate the Parameters of the Gumbel Distribution Function by Simulation

Genetic algorithm

Gumbel Distribution

likelihood Function

loss Function

الخوارزمية الجينية

توزيع كامبل

الامكان الاعظم

دالة الخسارة

Salam

Ali

Shurooq

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In this research, the focus was on estimating the parameters on (min- Gumbel distribution), using the maximum likelihood method and the Bayes method. The genetic algorithmmethod was employed in estimating the parameters of the maximum likelihood method as well as the Bayes method. The comparison was made using the mean error squares (MSE), where the best estimator is the one who has the least mean squared error. It was noted that the best estimator was (BLG_GE).

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Publication Date

Thu May 18 2023

Journal Name

Journal Of Engineering

Optimal Dimensions of Small Hydraulic Structure Cutoffs Using Coupled Genetic Algorithm and ANN Model

optimization

genetic algorithm

artificial neural networks

geo-Studio

uplift pressure

exit gradient

factor of safety.

Rafa Hashim

Rizgar Ahmed

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A genetic algorithm model coupled with artificial neural network model was developed to find the optimal values of upstream, downstream cutoff lengths, length of floor and length of downstream protection required for a hydraulic structure. These were obtained for a given maximum difference head, depth of impervious layer and degree of anisotropy. The objective function to be minimized was the cost function with relative cost coefficients for the different dimensions obtained. Constraints used were those that satisfy a factor of safety of 2 against uplift pressure failure and 3 against piping failure.
Different cases reaching 1200 were modeled and analyzed using geo-studio modeling, with different values of input variables. The soil wa

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(11)

Publication Date

Fri May 15 2015

Journal Name

Euphrates Journal Of Agricultural Science

Performance Evaluation of field and genetic for genotype selection from Tomato Lycopersicon esculeuntum Mill.

Mohammed Mahmood

Ayad Waleed Abdulla

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The study was conducted at the fields of the Department of Horticulture and Landscape Gardening,College of Agriculture, University of Baghdad during the growing seasons of 2013- 2014 .forPerformance of Evaluation Vegetative growth and yield traits and estimate some important geneticparameter on seven selected breed of tomato which (S1-S7 ) Pure line. the results found significantdifferences between breeds in all study trails except clusters flowering number .S1 significantly plantlength which reached 227.3 .Also S1,S2 and S4 were significantly increased the number fruit for plant,Fruit weight Increased in S3 ,S6 and plant yield. Increased in S1, S4 ,S5. Genetic variation valueswere low in Floral clusters , TSS and fruit firmest and medium i

Publication Date

Tue Jan 01 2019

Journal Name

Journal Of Global Pharma Technology

Study of the genetic diversity in three species belonging to family: Daphniidae (Crustaceae, Cladocera) collected from different regions in Baghdad Province/Iraq

Albhadly B.S.

Mohammed

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(2)

Publication Date

Thu Oct 01 2015

Journal Name

Al-academy

When Krochh aesthetic implications and their impact in raising the artistic and aesthetic taste among the students of the Department of Art Education: صلاح رهيف أمير

Salah

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The goal of current research to:1 - Know when aesthetic implications (Korchh)2 - To form the structure of systemic indicators and results that reflect the visions of intellectual, philosophical and aesthetic art for this study.The theoretical framework for the study of the search for the meaning of beauty, definition ( Krochh) being a philosopher, his views, his own aesthetic philosophy, knowledge, art and beauty, as well as a subject of artistic and aesthetic taste and Study in Art Education.The goals have been achieved during the search of Investigation theoretical framework for the search, which tried (INT) to form a clear vision check the second goal by the indicators reached.In light of this, the researcher recommended the need for

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Publication Date

Sat Jan 01 2022

Journal Name

Journal Of The Mechanical Behavior Of Materials

Time and finance optimization model for multiple construction projects using genetic algorithm

Musaab Falih

Sawsan Rasheed

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Abstract<p>Construction contractors usually undertake multiple construction projects simultaneously. Such a situation involves sharing different types of resources, including monetary, equipment, and manpower, which may become a major challenge in many cases. In this study, the financial aspects of working on multiple projects at a time are addressed and investigated. The study considers dealing with financial shortages by proposing a multi-project scheduling optimization model for profit maximization, while minimizing the total project duration. Optimization genetic algorithm and finance-based scheduling are used to produce feasible schedules that balance the finance of activities at any time w</p> ... Show More

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(5)

Publication Date

Sun Sep 15 2024

Journal Name

Iraqi Journal Of Pharmaceutical Sciences( P-issn 1683 - 3597 E-issn 2521 - 3512)

Biomarkers of Oxidative Stress in Diabetic Microvascular Complications Review Article

Mhaibes S.H.

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Reactive oxygen species (ROS) are produced as a result of biochemical processes that are not in balance with the body's antioxidant defense mechanism. This metabolic dysfunction is referred to the oxidative stress (OS). Metabolic dysfunction-associated diseases are affected by changes in the redox balance. It is now widely recognized that oxidative stress significantly affects diabetes mellitus (DM), particularly type 2 diabetes. The biochemical changes associated with DM could disturb the oxidative milieu, leading to several microvascular complications in diabetic patients. Thus, DM is a perfect disease to explore the harmful consequences of oxidative stress and how to treat it. Oxidative stress triggered by hyperglycemia is

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(4)

(2)

Publication Date

Fri Apr 01 2016

Journal Name

Nurse Education Today

Diabetes knowledge of nurses in different countries: An integrative review

Abdulellah

Ali

Leila

Lin

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(52)

Publication Date

Sun Jan 01 2023

Journal Name

The Egyptian Journal Of Hospital Medicine

Changes in Interleukin-35 (IL-35), Anti-TSHR antibody and Human Insulin- like Growth Factor 1 Receptor (IGF1R) in Graves’ Disease Patients Treatedwith Radioactive Iodine

Samara Assad

Rakad M. Kh

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Publication Date

Thu Oct 08 2026

Journal Name

Journal Of Al-mamoon College

Subject Review: Toxic leadership in the workplace environment

The leadership has received significant attention from researchers for its positive impact on workers and organizational success. Recently

studies have begun to focus on the darker side of leadership and its impact on followers and the work environment. Toxic leadership has been identified as the most dangerous leadership style

resulting in both material and moral costs to organizations in various aspects. Toxic leadership affects the motivation of subordinates

their ability to accomplish tasks

and their desire to continue working. Toxic leaders employ intimidation

exclusion

bullying

threats

and marginalization of subordinates

negatively impacting their well-being and mental health. Therefore

it has become imperative for organizations to implement appropriate mechanisms to prevent the spread of such destructive toxic behaviors on both individual and organizational levels. Thus

the current research aims to identify toxic leadership by reviewing its most important literature and examining the key behaviors and traits of toxic leaders

as well as their impact on followers and the organizational environment.

مصطفى عبدالعباس

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حضيت القيادة باهتمام كبير من قبل الباحثين ودورها الإيجابي في التأثير على الموظفين ونجاح المنظمات، في الآونة الأخير بدأت الدراسات تركز على الجانب المظلم للقيادة وتأثيرها على التابعين وبيئة العمل، وقد تم تحديد القيادة السامة بأنها أخطر الأساليب القيادية التي تتسبب بتكاليف مادية ومعنوية على المنظمات بمختلف جوانبها، ان القيادة السامة تأثر على دوافع المرؤوسين وقدرتهم على انجاز المهام، ورغبتهم في الاستمرار في

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