The present study was conducted to evaluate the effect of fungi Gigaspora margarita and Glomus desriticola in stimulating the resistance of the capsicum annuum L. towards the chromium and lead after 60 days, planting and using the pots in the glass house. The highest concentration of chromium and lead in the root was found in the presence of the mycorrhizal mixture (194.93, 150.40) μg / g, respectively, compared to the lowest concentration (90.69, 79.37) μg / g respectively, while the highest concentration of chromium and lead in the shoot was found in the presence of the mycorrhizal mixture (94.63, 79.33) μg / g respectively, compared with the lowest concentration in the control treatment (72.58, 60.70) μg / g respectively. The results showed the highest uptake efficiency and low translocation and phytoextraction efficiency of chromium and lead (179.73, 0.49 and 19.56) μg / g respectively for chromium and (144.63, 0.53 and 15.29) μg / g respectively for lead. The highest percentage of mycorrhizal mixture was recorded in the Intensity of the Mycorrhizal Colonization in the root System and root Fragments reached to (23.61, 26.50) % respectively, while the lowest percentage in mixing (chromium+lead) was (13.22, 13.47) % respectively. The highest percentage of mycorrhizal dependency was found in the mycorrhizal mixture with mixing (chromium+lead) which was 193.16% compared with the least of mycorrhizal dependency in Gigaspora margarita reached 98.34%. The lowest magnesium content in the control treatment was 28.36 mg / dry weight while the mycorrhizal mixture recorded the highest content of 33.41 mg / dry weight. The highest activity of guaiacol peroxidase and glutathione reductas in the treatment of the mycorrhizal mixture and mixing to heavy metals was (50.93, 10.11) absorption unit / gw fresh roots respectively compared with the lowest activity of the enzyme in the control was (31.48, 3.55) absorption unit / gw fresh roots respectively, all the tables showed significant differences.