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Personalised Warfarin Dosing in Children Post-cardiac Surgery
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Abstract<p>Warfarin dosing is challenging due to a multitude of factors affecting its pharmacokinetics (PK) and pharmacodynamics (PD). A novel personalised dosing algorithm predicated on a warfarin PK/PD model and incorporating CYP2C9 and VKORC1 genotype information has been developed for children. The present prospective, observational study aimed to compare the model with conventional weight-based dosing. The study involved two groups of children post-cardiac surgery: Group 1 were warfarin naïve, in whom loading and maintenance doses were estimated using the model over a 6-month duration and compared to historical case-matched controls. Group 2 were already established on maintenance therapy and randomised into a crossover study comparing the model with conventional maintenance dosing, over a 12-month period. Five patients enrolled in Group 1. Compared to the control group, the median time to achieve the first therapeutic INR was longer (5 vs. 2 days), to stable anticoagulation was shorter (29.0 vs. 96.5 days), to over-anticoagulation was longer (15.0 vs. 4.0 days). In addition, median percentage of INRs within the target range (%ITR) and percentage of time in therapeutic range (%TTR) was higher; 70% versus 47.4% and 83.4% versus 62.3%, respectively. Group 2 included 26 patients. No significant differences in INR control were found between model and conventional dosing phases; mean %ITR was 68.82% versus 67.9% (<italic>p</italic> = 0.84) and mean %TTR was 85.47% versus 80.2% (<italic>p</italic> = 0.09), respectively. The results suggest model-based dosing can improve anticoagulation control, particularly when initiating and stabilising warfarin dosing. Larger studies are needed to confirm these findings.</p>
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Publication Date
Wed Mar 10 2021
Journal Name
Baghdad Science Journal
Reasons of Dust Storms Increase in Iraq
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Currently regions in the world are much affected with dust storms, rising and suspended dust, as Iraq is suffering of this state as well within an eye-catching manner, whereas the storms leave negative traces on environment and public health and many of the other vital utilities. This research aims to diagnosis of the reasons that resulted in increment of dust storms in Iraq basing on some recorded data and to be analyzed in conformity with the prevalent theories and concepts at the atmospheric science and environmental physics. Generally the study, has illustrated that the climate changes and increase of temperatures averages because of green house effect, that followed by clear changes at thermal wind and jet stream, that caused to ins

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Publication Date
Sun Apr 01 2018
Journal Name
Journal Of Educational And Psychological Researches
Discipline in the classroom (problems and solutions)
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Research Summary

First: the problem of research and its importance

      The teacher's success in facilitating the students' learning and growth according to the educational and educational goals set out, he must identify the problems of discipline of students in the classroom in terms of sources and reasons and types and methods of prevention and treatment and the teacher to remember that success in his teaching and instruction is not completed more fully once he has the information And knowledge of the subject of the lesson, but must understand the dynamics of the group (class group) and master the skills of classroom management, su

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Publication Date
Wed Dec 15 2021
Journal Name
Arab World English Journal
Aggressive Language in Literature: A Pragmatic Approach
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Aggression is a negative form of an anti-social behavior. It is produced because of a particular reason, desire, want, need, or due to the psychological state of the aggressor. It injures others physically or psychologically. Aggressive behaviors in human interactions cause discomfort and disharmony among interlocutors. The paper aims to identify how aggressive language manifests itself in the data under scrutiny in terms of the pragmatic paradigm. Two British literary works are the data; namely, Look Back in Anger by John Osborne (1956), and The Birthday Party by Harold Pinter (1957). This paper endeavors to answer the question of how aggressive language is represented in literature pragmatically? It is hoped to be significant to

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Publication Date
Mon Jan 01 2024
Journal Name
Journal Of Engineering
Improving Thermal Performance in the University Classrooms
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Universities are among spaces where it's important to ensure thermal comfort in indoor spaces, improving the occupants' well-being and productivity. The problem of the research was to study appropriate glazing systems for the spaces of the University of Baghdad because glazing systems are one of the most important elements of the indoor environments, and it has a major impact on the thermal performance of buildings. Glass is one of the most seasoned materials that are most utilized in the design. Since it is a diaphanous material, it allows sunlight to enter the building, increasing the space's temperature, cooling loads, and energy consumption in summer. The research followed the experimental method by studying and

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Publication Date
Sun Jan 01 2023
Journal Name
4th International Conference On Distributed Sensing And Intelligent Systems (icdsis 2023)
EcoSavvy: revolutionizing waste management in smart cities
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Publication Date
Mon Jan 01 2018
Journal Name
Journal Of Clinical And Diagnostic Research
Lymphocyte Apoptosis in Third Trimester of Pregnancy
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Publication Date
Mon Oct 01 2018
Journal Name
International Journal Of Electrical And Computer Engineering
Load balance in data center SDN networks
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In the last two decades, networks had been changed according to the rapid changing in its requirements. The current Data Center Networks have large number of hosts (tens or thousands) with special needs of bandwidth as the cloud network and the multimedia content computing is increased. The conventional Data Center Networks (DCNs) are highlighted by the increased number of users and bandwidth requirements which in turn have many implementation limitations. The current networking devices with its control and forwarding planes coupling result in network architectures are not suitable for dynamic computing and storage needs. Software Defined networking (SDN) is introduced to change this notion of traditional networks by decoupling control and

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Publication Date
Sun Mar 12 2017
Journal Name
Al-academy
The constructional shifts in Picassos Ceramics Search
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With the massive presence of the critical approaches &, artistical School, movements, methods, Concepts, & theories, which came to take its chance from arts in general view & the plastic arts in special view. The Searches of fine arts & what this methods present from excitement become the point for many questions, & go to the purposes to be useful. For the artistic Work to come out in aesthetic image, especially on the subject of reading& reception, & entering it into layout of multiple relationships, for the artistic Work to be more simulation of the appearances of the things & interpreted it in Accor.
Dance to aesthetic that Limited by the new method. With those Innovative Visions, & Composite Sy

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Publication Date
Tue Aug 15 2023
Journal Name
Al-academy
Digital technologies in the means of communication
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Modern digital technologies have affected the means of communication in terms of structure, function and methods of dealing with them, and the communication process has changed, becoming bilateral, reciprocal and interactive, after it was one-way and limited in circulation and the roles changed, so the receiver became the sender and reversed is correct, and the culture of the active user and the participant spread, and the communication process became continuous.
The international information network has provided new electronic channels in the media and communication that are not known and opened a new era for these means, which led to a trend towards digital media in an unprecedented way.
The new communication platforms are the re

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Publication Date
Sun Jun 05 2016
Journal Name
Baghdad Science Journal
Early Baldness in Males and Hormonal Changes
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Androgenetic alopecia (AGA) or baldness is a common form of hair loss, affecting men more than women .The exact causes and pathogenesis of baldness are not well understood. A search for new drug is still needed. This study aims to evaluate the role of gonadotropins hormones in hair loss in males and its possibility to be used as treatment target. A total of 78 volunteers 43 with baldness and 35 healthy men were participated in this study. Their age ranged between (20-49) years, the studied groups were divided into two categories: firstly according to age (group1: 20-29 year), (group2: 30-39 year),and (group3: 40-49 year).Secondly according to baldness degree. LH and FSH were measured by using Enzyme Linked Immunosorbent Assay (ELISA) kits.

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