Warfarin dosing is challenging due to a multitude of factors affecting its pharmacokinetics (PK) and pharmacodynamics (PD). A novel personalised dosing algorithm predicated on a warfarin PK/PD model and incorporating CYP2C9 and VKORC1 genotype information has been developed for children. The present prospective, observational study aimed to compare the model with conventional weight-based dosing. The study involved two groups of children post-cardiac surgery: Group 1 were warfarin naïve, in whom loading and maintenance doses were estimated using the model over a 6-month duration and compared to historical case-matched controls. Group 2 were already established on maintenance therapy and randomised into a crossover study comparing the model with conventional maintenance dosing, over a 12-month period. Five patients enrolled in Group 1. Compared to the control group, the median time to achieve the first therapeutic INR was longer (5 vs. 2 days), to stable anticoagulation was shorter (29.0 vs. 96.5 days), to over-anticoagulation was longer (15.0 vs. 4.0 days). In addition, median percentage of INRs within the target range (%ITR) and percentage of time in therapeutic range (%TTR) was higher; 70% versus 47.4% and 83.4% versus 62.3%, respectively. Group 2 included 26 patients. No significant differences in INR control were found between model and conventional dosing phases; mean %ITR was 68.82% versus 67.9% (
Enjoy cinema privileged position , they have the ability to influence and the impact of including environs of prior art , and what distinguishes them , possessing motion picture , especially since the film possesses through its means technical ( camera , lighting, sound, editing , costume, scenery and makeup ) that work together in harmony and harmony to create enchanting fantasy world does not exist only in the imagination of corrupt officials . Out of imagination found that the art of make-up one of the means that enable it to create characters imagined located between simulate realistic characters (such manifestations of blood , cut leg, wounds , burns , etc. ..) and the figures are unrealistic , particularly in the
... Show MoreThis paper is devoted to the discussion the relationships of connectedness between some types of graphs (resp. digraph) and Gm-closure spaces by using graph closure operators.
Tuberculosis is caused by Mycobacterium tuberculosis; it is considered as one of the most common, infectious diseases and major causes of morbidity and mortality worldwide. A prospective study was conducted to obtain more clarification about the impact of causative agent and its treatment to enhance autoantibodies production such as ANCA and BPI which used as diagnostic markers for several diseases, and to provide further insight into the classical risk factors (age and sex).Seventy patients with tuberculosis involved in this study, 35 of them were untreated and 35 with treatment administration these patients were attending to directorate of general health national reference laboratory in Baghdad during the period between November/ 2012 and
... Show MoreThis work describes the effect of temperature on the phase transformation of titanium dioxide (TiO2) prepared using metal organic precursors as starting materials. X-ray diffraction (XRD) was used to investigate the structural properties of TiO2 gels calcined at different temperatures (300, 500, 700) ?C. the results showed that the samples have typical peaks of TiO2 polycrystalline brookite nanopowders after calcined at (300 ?C), which confirmed by (111), (121), (200), (012), (131), (220), (040), (231), (132) and (232) diffraction peaks. Also, XRD diffraction spectra showed the presence of crystallites of anatase with low proportion of rutile phase where calcined at (500 ?C), while rutile phase domains at (700 ?C). The crystallite size of
... Show MoreThe language of theatre is made by a number of physical tools and moral elements. So as the actors, costumes, lightings and accessories represent the physical aspects of the show, they also represent its moral aspect too. When they transform from plastic words in the space of the visual show to become signs carrying its indications that give the meaning through the link, overlap and arrangement of its movements so as to finally look like as wording in a sentence carries the meaning and represent the language of theatre speech.
The show usually sends the recipient continuous signs that go beyond the limits of expressions that are conveyed by these tools, and that cover the largest part of the meaning. So what is kept hidden or unannoun
Antacids are commonly used drugs which are considered inert and free of pharmacological effect by many patients and physicians. They are weak bases that neutralize the gastric acid and relief pain. These weak bases dissociate to neutralize gastric acid and form neutral salts. The ultimate goal of antacid therapy is to reduce the concentration and a total load of acid in gastric juice to a pH 4 - 5. This in vitro study was promised to study the acid neutralizing capacity (ANC) of six commonly available antacids tablets in the Iraqi market by using back titration method. The highest ANC values were for Rennie (17.131± 0.083 and 16.926± 0.052 mEq) in two different hydrochloric acid (HCl) concentrations 1N and 0.5 N, respectively. The static
... Show MoreThe discipline of International Relations has been a science for almost a century and has undergone considerable development and dynamism as a field of knowledge. In the aftermath of the First World War, traditional idealistic trends prevailed. Still, after the end of the Second World War, the theory of realism dominated the analysis of international relations, international politics, and its laws and mechanisms. With the inter-paradigm debate of the 1980s, a broad spectrum of theories of international relations emerged, the most significant of which are critical theories including feminism. Feminist theory has since become central to the debates about global phenomena among those who work in International Relations as a field. The paper at
... Show MoreTo cite the short stories of Kathrine Mansfield, all contain characters who are
revealed through their own thoughts. In her stories, the world is always seen through
the eyes of her characters in the form of points of view presented to the readers
through the characters' minds. This way of revealing characters and figuring out the
world, through the presentation of the characters' thoughts, is linked to the 'stream of
consciousness.' Kathrine Mansfield has been compared with Virginia Woolf in
particular in that both writers used the thoughts and the points of view of their
characters as material for their work through the stream of consciousness.
According to Leech and Short (1981), there are five linguistic techn
In the last few years, following the relative stability of the political, economic, and security environments, Iraq has embarked on a transformation towards an ambitious program of automation across various sectors. However, this automation program faces numerous challenges, including significant investments in technology and training, addressing social impacts, and combating widespread illiteracy
Feminism is a diverse set of social theories, political movements and ethos driven by women's causes. Feminists and feminists agree that the ultimate goal is to eliminate the forms of gender-related oppression It should be noted that feminism originated at the beginning as an emancipation movement aimed only at lifting the injustice and suffering of European women, but over time evolved and crystallized to form an independent thought in itself swimming against all the universals known to humanity in the relationship between male and female nature This study posits a hypothesis that the feminist movement is characterized by multiple and varied trends, different in its analyzes of the causes of women's oppression, but all agreed on the need t
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