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New Analytical Methods for Drugs Analysis A Comparative Study
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Four different spectrophotometric methods are used in this study for the determination of Sulfamethoxazole and sulfanilamide drugs in pharmaceutical compounds, synthetic samples, and in their pure forms. The work comprises four chapters which are shown in the following: Chapter One: Includes a brief for Ultraviolet-Visible (UV-VIS) Absorption spectroscopy, antibacterial drugs and sulfonamides with some methods for their determination. The chapter lists two methods for optimization; univariate method and multivariate method. The later includes different types, two of these were mentioned; simplex method and design of experiment method. Chapter Two: Includes reaction of the two studied drugs with sodium nitrite and hydrochloric acid for diazotization reaction followed by coupling with diphenylamine in acidic medium to form, a blue colored azo dye compound which exhibits maximum absorption (λmax) at 530 nm for sulfamethoxazole complex and 531 nm for sulfanilamide complex against the reagent blank and the concentration of these drugs were determined spectrophotometrically. The optimum reaction conditions and other analytical parameters were evaluated. In addition to classical univariate optimization, modified simplex method has been applied in optimization of the variables affecting the color producing reaction. The results show better optical characteristics for calibration curves and statistical data were obtained under optimum conditions obtained by multi simplex optimization, in comparison with those obtained via univariate method for two studied drugs. Beer’s law obeyed in the concentration range of 0.5-12.0 μg.mL-1, 0.5-7.0 μg.mL-1 for sulfamethoxazole and sulfanilamide respectively with molar absorptivity of 4.9617×104 L.mol-1.cm-1 for sulfamethoxazole and 5.9185×104 L.mol-1.cm-1 for sulfanilamide. The detection limits were 0.036 μg.mL-1 and 0.016 µg.mL-1 for the two complexes respectively by simplex method. No interferences from the studied excipients on the determination of these drugs were found therefore, the proposed methods were applied successfully II for the determination of the sulfamethoxazole and sulfanilamide in pharmaceutical compound and in synthetic samples. Chapter Three: Is based on the formation of condensation complexes of each drug with sodium 1,2-naphthoquinon-4-sulfonate as a chromogenic reagent. The absorbance values, for the formed complexes were measured at 460 nm for sulfamethoxazole and 455 nm for sulfanilamide; against reagent blank. Different variables affecting the completion of reaction have been carefully optimized following the classical univariate sequence and design of experiment (DOE) method and the results were obtained under optimum conditions by (DOE) optimization which shows better optical characteristics for calibration curves and statistical data in comparison with those obtained via univariate method for two studied drugs. The calibration graphs are linear in the ranges of (5.0-50.0) µg.mL-1 for sulfamethoxazole and (5.0-30.0) µg.mL-1 for sulfanilamide with detection limit 0.359 µg.mL-1for sulfamethoxazole complex and 0.536 µg.mL-1 for sulfanilamide complex. The molar absorptivity was found to be (7.0918×104 L.mol-1.cm-1) for sulfamethoxazole and (7.0774×104 L.mol-1.cm-1) for sulfanilamide by the design of experiment (DOE) method. Finally no interferences from the studied excipients on the determination of these drugs were found. The proposed methods have been successfully applied for the determination of sulfamethoxazole and sulfanilamide in their pharmaceutical preparation and synthetic samples. Chapter Four: Includes two parts; Derivative spectrophotometry and partial least-squares (PLS). Derivative spectrophotometry is based on the first and second derivative spectra of absorption which has been applied for simultaneous spectrophotometric determination of sulfamethoxazole and sulfanilamide in their mixture in the ultraviolet region. The method offers an advantage of getting rid of the resulting error in the values of absorption because of the presence of each drug with the presence of interferences from the excipients. It was found that the method is able to accurately estimate sulfamethoxazole in the range of (2.0-50.0) μg.mL-1; in mixtures containing III (2.0-30.0) μg.mL-1 of sulfanilamide, as (interferent). The results obtained, with the first derivative measurements, indicate that when the concentration of sulfanilamide is kept constant and the concentration of sulfamethoxazole varied, the peak amplitudes are measured at peak-to-baseline (223, 254,287 nm), peak to peak height between (223- 254 nm), (254-287nm). Moreover, the height at the zero cross of sulfanilamide at (235.62, 258.72 nm), heightto-height of the two zero crosses between (235.62-258.72 nm) and area under peak between (241.95-267.04 nm), (267.04-330 nm) were found to be in proportion to the sulfamethoxazole concentration therefore they are used for the determination of it. The careful inspection of the second derivative spectra obtained for the mentioned mixtures of sulfamethoxazole and sulfanilamide shows that peak to basline is at (239.5, 263.5, 267.75, 301, 215 nm) , height to basline is at zero cross is at (245.86, 271.28 nm) , peak to peak is between (239.5-264.25 nm), (239.5-267.75 nm), (271.28-301 nm), (215-239.5 nm), height to height is at two zero cross (245.86-271.28 nm) in addition to peak area at the interval between (254.12-281 nm), (286.95- 329.5 nm), (221.75-254.12 nm) measurements at specified wavelength could be used to quantify the exact concentration of sulfamethoxazole in presence of sulfanilamide. Sulfanilamide was determined for the range of (2.0-50.0) μg.mL-1; in a mixture containing (2.0-50.0) μg.mL-1 of sulfamethoxazole as (interferent). The procedure gave good results over the studied range of concentration depending on peak-to-baseline at (224, 246, 271 nm), height at zero cross at (241.95, 267.04 nm), peak to peak between (224-246 nm), (246-271 nm), height to height at two zero cross (241.95-271 nm) and area under the peak at (235.62-258.72 nm) measurements were found to be used for the determination of sulfanilamide in the first derivative technique. On other situation, the wavelengths are at 218 nm, 231 nm, 260 nm and 278 nm (peak to base line measurements), and height at two zero cross at 254 nm and 281 nm, and peak to peak measurements between (218-231 nm), (231-260 nm) and (260-278 nm), and height at zero cross at (254, 281 nm), wavelengths at (210-224 nm) , (224-245.84 nm) and (271.28-330 nm) peak area at the interval measurements were used for the estimation of sulfanilamide on second derivative.

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Publication Date
Mon May 01 2017
Journal Name
Energy
Solidification enhancement in a triplex-tube latent heat energy storage system using nanoparticles-metal foam combination
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Publication Date
Mon Dec 11 2023
Journal Name
International Journal Of Phytoremediation
Adsorption of methyl orange on low-cost adsorbent natural materials and modified natural materials: a review
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Recently a large number of extensive studies have amassed that describe the removal of dyes from water and wastewater using natural adsorbents and modified materials. Methyl orange dye is found in wastewater streams from various industries that include textiles, plastics, printing and paper among other sources. This article reviews methyl orange adsorption onto natural and modified materials. Despite many techniques available, adsorption stands out for efficient water and wastewater treatment for its ease of operation, flexibility and large-scale removal of colorants. It also has a significant potential for regeneration recovery and recycling of adsorbents in comparison to other water treatment methods. The adsorbents described herein were

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Publication Date
Wed Mar 29 2017
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
Development and in vitro Evaluation of Bioadhesive Vaginal Tablet using Econazole Nitrate as a Model Drug
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         In this study, a bioadhesive dosage form of eoconazole nitrate for vaginal delivery was designed using a combination of bioadhesive polymers: Carbopol 941 p and sodium carboxymethylcellulose or methylcellulose in different ratios. The bioadhesive strength was evaluated by measuring the force required to detach the tablet from sheep vaginal mucosal membrane. It was found that the bioadhesive force was directly proportional to Carbopol 941 p content in the different formulae. The formulae were tested for their swelling behavior using agar gel plate method. The results showed that formulae containing a combination of Carbopol 941 p and sodium carboxymethylcellulose had greater swelling index

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Publication Date
Mon Jan 01 2024
Journal Name
Scripta Medica
Eruption of first permanent molar among a group of Iraqi children in relation to nutritional status
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Background/Aim: The timing of a tooth's eruption can be affected by a variety of factors. The nutritional status has an impact on the development of a child's body. The purpose of the study was to analyse the number of children aged 6 to 9 in an Iraqi Arab population who had erupted permanent first molars and to examine how nutritional status affected the timing and level of emergence. Methods: A total of 330 boys and girls, in first grade elementary school, made up the sample. First molars that had erupted were noted, along with the level of the eruption. Each child's nutritional status was evaluated by recording their height and weight and body mass index (BMI) value was compared to the 2007 WHO reference. Results: Girls had highe

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Wed Oct 18 2023
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The Effect of a Training Program on the Diabetic Patients Utilizing Skills of Insulin Injection Technique
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Objectives: The study aims to evaluate patients’ performance toward insulin injection after training program to
identify the variation in skill of patients in insulin injection technique with regard to some variable (i.e.
educational level and duration of insulin injection.
Methodology: A quasi experimental study has been conducted on diabetic patients.
An observational checklist had been prepared which consisted of 4 main areas with 37 sub-items, which are
syringe preparation for injection, insulin drawing; skin preparation for injection and insulin injection. Each of the
sub-items has 2 options yes or no. One score for positive answer and zero for no.
The sample of the study consisted of (n =30) males and females

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Publication Date
Tue Jun 30 2009
Journal Name
Al-kindy College Medical Journal
Abdominal Distention and Acute Urinary Retention secondary to Congenital Distal Vaginal Obstruction in a Newborn Female
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Congenital distal vaginal obstruction is usually asymptomatic in a newborn female. On rare occasions, it may present as an acute emergency with life threatening complications.This paper is reporting the rare condition of two newborn females presenting urgently with abdominal distension and acute urinary retention as a result of congenital distal vaginal Obstruction. The case history and urgent management shall be presented and both conditions shall be discussed.

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Publication Date
Fri Sep 15 2023
Journal Name
Al-academy
Drawing inspiration from organic natural forms in stereoscopic sculptures (A survey according to Evo-devo science)
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By reading the book (Endless Forms Most Beautiful: The New Science of Evo Devo) by Sean B. Carroll, new horizons opened up about the nature of the formation of the living organism. Although he presented the idea that the artist was influenced by the material assets of nature in his holographic art formations, the new science of Evo-Devo (Evolutionary Developmental Science) provided models worth standing on when comparing the similarity of the formation of living organisms on the one hand, and the formation of works of art with holographic organic bodies on the other. But the excitement lies in the fact that the formation of living natural organisms is often driven by subtle intelligent mechanisms that are different from the mechanisms us

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Publication Date
Wed Dec 30 2015
Journal Name
Journal Of Chemical, Biological And Physical Sciences
Prevalence of Autoimmune Thyroid Disorders in a Sample of Iraqi Infertile Women with Polycystic Ovary Syndrome
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The present study aims to estimating the prevalence of autoimmune thyroid disorders in Iraqi infertile women with polycystic ovary syndrome (PCOS). Eighty-five Iraqi women, with age range (19-45) years, were divided into three groups; first group included 33 women with PCOS; second group included 30 women without PCOS; while third group included 22 fertile women as controls. The clinical data [age, body mass index (BMI), and menstrual status] have been recorded. Blood samples were collected to determine the levels of reproductive hormones [estradiol (E2), luteinizing hormone (LH), and follicle stimulating hormone (FSH)]; and thyroid hormones [triiodothyronine (T3) and thyroxin (T4)]. Also, autoimmune thyroid antibodies assessment h

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Publication Date
Sat Mar 30 2024
Journal Name
Al-qadisiyah Journal For Engineering Sciences
Investigation of an automobile air-conditioner with a liquid-suction heat exchanger using R134a and R1234yf
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Air-conditioning systems (ACs) are essential in hot and humid climates to ensure acceptable ambient air quality as well as thermal comfort for buildings users. It is essential to improve refrigeration system performance without increasing the effects of global warming potential (GWP) and ozone depletion potential (ODP). The main objective of this study is to evaluate the performance of an air conditioning system that operates with a liquid suction heat exchanger (LSHX) through implementing refrigerants with zero OPD and low GWP (i.e., R134a and R1234yf). Liquid suction heat exchanger (LSHX) was added to an automobile air conditioning system (AACS).When Liquid suction heat exchanger was added to the cycle, primary results indicated t

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Publication Date
Thu Jul 10 2025
Journal Name
Journal Of Baghdad College Of Dentistry
The Dental Caries and Some Salivary Constituents among a Group of Ten Years Iraqi Passive Smokers
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Background: Passive smoking and dental caries affect the integrity of the health of individuals and both of them affected by sociodemographic characteristics of those individuals. This research aimed to investigate the severity of dental caries in relation to salivary magnesium and zinc of stimulated whole saliva of a group of 10 years passive smokers in comparison with normal subjects. Materials and methods: the study group included 40 subjects (20boys and 20 girls), with an age of 10 years of passive smokers determined by a questionnaire. The control group included 40 normal subjects of the same gender and age of the study group. The diagnosis and recording of dental caries was measured by (D1-4MFS & d1-4mfs) index according to the criter

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