Standardized uptake values, often known as SUVs, are frequently utilized in the process of measuring 18F-fluorodeoxyglucose (FDG) uptake in malignancies . In this work, we investigated the relationships between a wide range of parameters and the standardized uptake values (SUV) found in the liver. Examinations with 18F-FDG PET/CT were performed on a total of 59 patients who were suffering from liver cancer. We determined the SUV in the liver of patients who had a normal BMI (between 18.5 and 24.9) and a high BMI (above 30) obese. After adjusting each SUV based on the results of the body mass index (BMI) and body surface area (BSA) calculations, which were determined for each patient based on their height and weight. Under a variety of different circumstances, SUVs were evaluated based on their means and standard deviations. Scatterplots were created to illustrate the various weight and SUV variances. In addition to that, the SUVs that are appropriate for each age group were determined. SUVmax in the liver was statistical significantly in obese BMI and higher BSA, p- value <0.001). Age appeared to be the most important predictor of SUVmax and was significantly associated with the liver SUVmax with mean value (58.93±13.57). Conclusions: Age is a factor that contributes to variations in the SUVs of the liver. These age-related disparities in SUV have been elucidated as a result of our findings, which may help clinicians in doing more accurate assessments of malignancies. However, the SUV overestimates the metabolic activity of each and every individual, and this overestimation is far more severe in people who are obese compared to people who have a body mass index that is normal (BMI
