Background: Parkinson's disease (PD) is a neurodegenerative aging disease, with idiopathic PD being most common. Gastrointestinal tract disorders (GITD) and microbiota changes may trigger idiopathic PD. Neurotoxins from microbiota can travel from the gut to the brain via the brain-gut axis (BGA), leading to α-syn protein misfolding and dopaminergic neuron death. Methods: The aim of the current study was to investigate the link between PD and GITD by measuring several biochemical and immunological markers in 142 patients. The biochemical markers measured were vitamins B6, B12, and D, calcium, serotonin, ghrelin, dopamine, and α-syn protein. The immunological markers included transforming growth factor-beta (TGF-β), tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interferon-gamma (IFN-γ). All markers were measured using the Enzyme-Linked Immunosorbent Assay (ELISA) technique. Results: PD patients were significantly older (63.76±12.29 years) compared to GITD and control groups (41.00±15.54 and 41.25±18.30 years, respectively). Males predominated in the PD group (74.5%), while females were more common in the GITD and control groups. PD and GITD patients showed significantly lower levels of vitamins and neurotransmitters but higher calcium and α synuclein compared to controls. Immunological markers were elevated in PD and GITD groups, with significant differences between them (P-value < 0.001). Conclusion: The study concluded that certain biochemical and immunological markers provide strong evidence of the brain-gut axis's involvement in the initiation of idiopathic Parkinson's disease.
The influence of Toxoplasma gondii in the pathogenesis of hepatic disease has lately had considerable attention. The objective of this study is to assess the seroprevalence of T. gondii infection in patients with chronic liver disease from Baghdad-Iraq. All patients have attended Gastroenterology and Hepatology Teaching Hospital, Medical city in Baghdad, Iraq An analytical case–control study was achieved from September to November 2018. Seventy male patients with chronic liver disease (CLD) and 70 control males (free of chronic liver diseases) participated in this study, their ages were between (18-80) years old. Serum samples were taken from all subjects and were analysed with enzyme-linked imm
... Show MoreCOVID 19 has spread rapidly around the world due to the lack of a suitable vaccine; therefore the early prediction of those infected with this virus is extremely important attempting to control it by quarantining the infected people and giving them possible medical attention to limit its spread. This work suggests a model for predicting the COVID 19 virus using feature selection techniques. The proposed model consists of three stages which include the preprocessing stage, the features selection stage, and the classification stage. This work uses a data set consists of 8571 records, with forty features for patients from different countries. Two feature selection techniques are used in
In recent years, predicting heart disease has become one of the most demanding tasks in medicine. In modern times, one person dies from heart disease every minute. Within the field of healthcare, data science is critical for analyzing large amounts of data. Because predicting heart disease is such a difficult task, it is necessary to automate the process in order to prevent the dangers connected with it and to assist health professionals in accurately and rapidly diagnosing heart disease. In this article, an efficient machine learning-based diagnosis system has been developed for the diagnosis of heart disease. The system is designed using machine learning classifiers such as Support Vector Machine (SVM), Nave Bayes (NB), and K-Ne
... Show MoreIn this paper, an eco-epidemiological model with media coverage effect is proposed and studied. A prey-predator model with modified Leslie-Gower and functional response is studied. An -type of disease in prey is considered. The existence, uniqueness and boundedness of the solution of the model are discussed. The local and global stability of this system are carried out. The conditions for the persistence of all species are established. The local bifurcation in the model is studied. Finally, numerical simulations are conducted to illustrate the analytical results.
Crude-colicin was extracted from g.coli isolated from urinary tract
infection patients. Toxicity of various concentrations of crudt: colicin
on the viability of immune cells [phagocytic ceUs(M0,PMN) and lymphocytes] was studied. Results indicated that toxicity ciTect of crude colicin is dependent on concentration. Low concentrations (I0,
25, 50 mg/ml) didn't have toxic effects, but when there was an increase in the consternation of this extract, the viability of the immune cell s began to decrease.
In this study, the magic nuclei is divided into two groups, one of them is light group and the other is middle group, it was calculated shell corrections for all nuclei, and also it was concluded the relationship between cross sections for nuclear reactions ()α,n and the mass number (A) for all nuclei to incident neutrons (14.5 MeV). We found empirical equations to asymmetry parameter (N-Z)/A as function of mass number and for that two groups: for A=38 to A=40 light nuclei.()0534.10263.0+−=−AAZN for A=50 to A=89 middle nuclei. ()408.00151.00001.02−+=−AAAZN for A=90 to A=144 middle nuclei. ()0711.10221
The relationship of hyperuricemia to kidney disease, diabetes, hypertension and the risk of cardiovascular diseases remain controversial. The aim of this study is to evaluate the use of uric acid (UA) levels to find the higher risk of cardiovascular disease (CVD) in patients with end stage renal disease that have diabetic nephropathy (DN), nephropathy with hypertension (NH) and patients with both diabetic nephropathy with hypertension (DNH). This study deals with 115 patients with end-stage renal disease under hemodialysis sub-grouped into 35 patients with (DN), 40 patients with (NH), and 40 patients with (DNH). Some biochemical parameters were determined in the serum of all participants such as HbA1c, fasting blood glucose (FBG), UA, urea,
... Show MoreA mathematical eco-epidemiological model consisting of harvested prey–predator system involving fear and disease in the prey population is formulated and studied. The prey population is supposed to be separated into two groups: susceptible and infected. The susceptible prey grows logistically, whereas the infected prey cannot reproduce and instead competes for the environment’s carrying capacity. Furthermore, the disease is transferred through contact from infected to susceptible individuals, and there is no inherited transmission. The existence, positivity, and boundedness of the model’s solution are discussed. The local stability analysis is carried out. The persistence requirements are established. The global behavior of th
... Show MorePeriodontitis is one of the most prevalent bacterial diseases affecting man with up to 90% of the global population affected. Its severe form can lead to the tooth loss in 10-15% of the population worldwide. The disease is caused by a dysbiosis of the local microbiota and one organism that contributes to this alteration in the bacterial population is Prophyromonas gingivalis. This organism possesses a range of virulence factors that appear to contribute to its growth and survival at a periodontal site amongst which is its ability to invade oral epithelial cells. Such an invasion strategy provides a means of evasion of host defence mechanisms, persistence at a site and the opportunity for dissemination to other sites in the mouth. However, p
... Show MorePeriodontal diseases such as gingivitis and periodontitis are considered common diseases. This study is aimed to predicate these diseases using non-harmful specimens such as saliva throughout the detection of some parameters. In the beginning, a random 51 patients' saliva was collected from outpatients who suffered from different degrees of periodontal diseases. Concurrently, another 40 people who appeared to be healthy were collected, and both patients and healthy people were subjected to a questionnaire form and diagnosed by a specialist dentist. The results of this study revealed that there is no significant difference between males and females in infection with periodontal diseases. As well, smoking is not acting as the main f
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