Synthesis and Identification of Some New Derivatives of Schiff bases Compounds and study their Biological activity

Ibtisam K Jassim; Nisreen H. Karam; Kaleda A. Aomran

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Publication Date

Tue Jul 01 2008

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Synthesis and Identification of Some New Derivatives of Schiff bases Compounds and study their Biological activity

Ibtisam K Jassim

Nisreen H. Karam

Kaleda A. Aomran

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A new series of Schiff bases compounds , containing an azomethine linkage was synthesized and expected to be biologically active .The structures of these compounds were identified by IR , Uv/vis spectra , melting points and followed by T.L.C.The biological activity of these compounds was studied

Publication Date

Sun Oct 06 1996

Journal Name

Iraqi Journal Of Chemistry

Synthesis of new Schiff bases derived from [3-amino-3-C-cyano-3-deoxy-1,2:5,6-di-O-isopropylidene-α-D-allofuranose

Y. Ali

M. J.

Khalid Waleed S

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Aromatic Schiff-bases are known to have antibacterial activity, but most of these compounds are sparingly soluble in water. The present work describes the synthesis of new Schiff-bases derived from branched aminosugars. Treatment of 3-Amino-3-Cyano-3-Deoxy-1,2:5,6-Di-O-Isopropylene-α-D-Allofuranose (1) with the aldehydes (2) under reflux in methanol afforded the Schiff-bases (3) in good yields. The new Schiff-bases were in accord with their NMR, IR spectral data and elemental analysis.

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Publication Date

Sun Jan 01 2017

Journal Name

Al-mustansiriyah

Synthesis, Spectroscopic and Biological Studies of a New Some Complexes with N-Pyridin-2-Ylmethyl-Benzene-1, 2Diamine

Shaimaa

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Publication Date

Sun Dec 01 2024

Journal Name

Russian Journal Of General Chemistry

Synthesis, Characterization, and Biological Evaluation for New Derivatives Based on 2Сhloro-N-[4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl]acetamide

N. M.

K. A.

H. A.

J. H.

H. S.

R. K.

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Publication Date

Sun Dec 01 2024

Journal Name

Russian Journal Of General Chemistry

Synthesis, Characterization, and Biological Evaluation for New Derivatives Based on 2Сhloro-N-[4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl]acetamide

N. M.

K. A.

H. A.

J. H.

H. S.

R. K.

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Publication Date

Tue May 29 2018

Journal Name

Journal Of Pharmaceutical And Scientific Research

Synthesis and characterization of substituted 1, 2,4-triazole and their derivatives on poly ethylene

1

2

4-triazole

1

2

4-triazole-3-one

1

2

4-triazole-3-thione

Rana

Zainab

Entesar

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Abstract New derivatives of 1,2,4- triazole , 1,2,4-triazole -3-one and 1,2,4-triazole-3-thione were obtained through this research. Acid hydrazide derivative was present from reaction of poly acryloyl chloride with hydrazine hydrate in presence of DMF as a solvent then reacted with benzonitrile and its derivatives to give 1,2,4-triazole derivatives. After that reaction of poly acryloyl chloride with semicarbazide and semithiocarbazide to form semicarbazone and semithiocarbazone derivatives respectively. Finally, closing of semicarbazone and semithiocarbazone derivatives with 2% NaOH gave 1,2,4-triazole -3-one and 1,2,4-triazole-4-thione derivatives respectively. These new synthesized products have been characterized by infrared, 1 H-n

Publication Date

Fri Dec 01 2023

Journal Name

Russian Journal Of General Chemistry

Preparation, Characterization, and Biological Activity of Mixed Schiff Base Ligand Complexes with Amino Acid L-Proline

Taghreed

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(10)

Publication Date

Fri Dec 01 2023

Journal Name

Russian Journal Of General Chemistry

Preparation, Characterization, and Biological Activity of Mixed Schiff Base Ligand Complexes with Amino Acid L-Proline

N. M.

S. M. H.

M. H.

Taghreed H.

S. R.

A.

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(10)

Publication Date

Fri Dec 01 2023

Journal Name

Russian Journal Of General Chemistry

Preparation, Characterization, and Biological Activity of Mixed Schiff Base Ligand Complexes with Amino Acid L-Proline

N. M.

S. M. H.

Mazin Hasan

Taghreed H.

Salam R.

Aly

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(10)

Publication Date

Fri Jul 05 2013

Journal Name

Pharmacie Globale International Journal Of Comprehensive Pharmacy

SYNTHESIS OF NEW PROPRANOLOL DERIVATIVES AS POSSIBLE PRODRUGS

propranolol

prodrugs

bioavailability

first- pass metabolism

Mohammed H

May Mohammed Jawad

Amera Abbas

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Propranolol is a nonselective-adrenergic blocker used in the treatment of hypertension, cardiac arrhythmias, and angina pectoris. A significant problem in propranolol therapy is that it undergoes extensive presystemic metabolism after oral administration leading to reduced bioavailability. In this study, two new propranolol derivatives have been designed, synthesized and characterized. These compounds were formed by acylation of propranolol followed by nucleophilic substitution reaction of acylated propranolol, these derivatives were analyzed for IR, CHN, melting points, and evaluated for their lipophilic properties compared with propranolol. The lower partition coefficient of these two derivatives revealed that the prodrug approach may be

Publication Date

Wed Dec 30 2020

Journal Name

Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)

Synthesis, Characterization and Preliminary Anti-inflammatory Evaluation of New Fenoprofen Hydrazone Derivatives

Keywords: Fenoprofen hydrozone derivatives

Anti-inflammatory

Paw edema method

Hayder M.

Muthanna

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New hydrazone derivatives of Fenoprofen were synthesized and evaluated for their anti-inflammatory activity by means of egg white induced paw edema method. All the synthesized target compounds were characterized by FT-IR spectroscopy, 1HNMR analysis and by measure of their physical properties. The synthesis of the target compounds(H1-H4) was accomplished by multistep reaction procedures. The synthesized target compounds were show activity in reducing paw edema thickness and their anti-inflammatory effect was comparable to that of the standard (Fenoprofen) except for compound H3 which show anti-inflammatory activity higher than Fenoprofen.

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