Interleukin -33 is a new member of the IL-1 superfamily of cytokines that is expressed mainly by stromal cells.Its expression is upregulated following pro-inflammatory stimulation.Aim of the present study was to assess the serum IL-33 level and its relationship with inflammatory biomarker CRP in Iraqi females patients with celiac disease. Thirty five patients with celiac disease (CD) and thirty healthy individuals as control group were enrolled in this study,their age ranged (20-35) year.Anti-Gliadin IgA ,IgG and Anti-Tissue IgA ,IgG were estimated in all subjects as diagnostic parameters .ESR and CRP were assayed as inflammatory biomarkers. IL-33 was determined in patients and control groups.The results of the present study revealed a highly significant increase in anti-gliadin (IgA ,IgG) , anti-tissue (IgA, IgG) ,ESR,and CRP levels in CD patients compared to control. While no significant increase in IL-33 level in CD patients compared to control was found. In conclusion, IL-33 could be considered as a biomarker for Celiac Diseases, and it is correlated positively with inflammatory biomarker"CRP" in Iraqi women patients with CD
This research examines the evolution of Turkey's foreign policy in dealing with international crises, especially after 2011, when Turkey shifted from a "zero problems" approach to a more active and interventionist foreign policy in regional issues, such as the Syrian crisis and the Eastern Mediterranean crises. The importance of this study lies in its focus on the experience of a regional power in a turbulent environment, reviewing Turkey's success or failure in managing these crises through various tools. This study focuses on outlining the theoretical framework of the concept of international crisis management, analyzing Turkey's tools for dealing with crises, studying the practical models of Turkey's role in regional crises, and
... Show MoreObjectives: This study investigates the U.S.-China competition in the field of artificial intelligence (AI), focusing on its implications for both countries’ military strategies. It also offers a forward-looking assessment of how this rivalry may influence international security and geopolitical stability. Methods: The research adopts an integrative theoretical framework combining realism—which emphasizes military power and strategic dominance—and technological innovation theory, which highlights the role of emerging technologies in global power shifts. A descriptive and analytical approach is employed, synthesizing academic literature, policy reports, and strategic documents from 2010 to 2030. Results: The U.S.-China AI compe
... Show MoreTicagrelor (TCG) is an effective P2Y12 receptor antagonist used to prevent atherothrombotic cardiovascular events; however, its poor solubility and limited permeability (BCS Class IV) restrict its oral bioavailability. Spanlastic Nanovesicles (SNVs), composed of nonionic surfactants and edge activators, offer a promising strategy to enhance drug solubility and permeability. This study aimed to develop and optimize TCG-loaded SNVs using the ethanol injection method, validate a sensitive HPLC method for TCG quantification, and evaluate the pharmacokinetic and antiplatelet performance of the optimized formulation in rats.
Massive efforts have been focused on designing of new anticancer medications. One of these approaches is inhibiting histone deacetylase (HDAC) which have a major role in regulation of cellular epigenetic processes. The non- selectivity of HDAC inhibitors is the major limitation for their use, therefore, recent researches have been oriented toward introducing of selective(HDAC) inhibitors through inhibition of HDAC2 and HDAC6 enzymes. A set of pyrazoline derivatives was designed and virtually studied by means of molecular docking, ADME, and molecular dynamics (MD) simulations. Compound 5 showed promising virtual binding affinity on the HDAC 2 and 6 inhibitors, and exhibited more in silico affinities to (4LXZ)& (5EEI) respectively than SAHA.
... Show MoreBovine theileriosis, caused by Theileria annulate, is disease affecting cattle and buffaloes worldwide. The current study aimed to screen the blood samples of 30 naturally suspected local buffaloes infected with Theileria species. The blood samples were initially examined by light microscopic and then the positive samples were subjected to PCR reactions. All 30 animals indicated clinical symptoms, such as high fever, loss of appetite, the presence of the hard tick, and enlargement of lymph nodes. The amplified products of 18S rRNA were analyzed, along with molecular detection of the drug-binding site alterations and interrelated changes in the cytochrome b (cyto b) gene. Blood smears revealed the presence of infected erythrocytes wi
... Show MoreOur search is composed from a general introduction dealing with the legal translator definition and then the most important features of the legal text, followed by seven Glossaries concerned with the diagnosis of some of the most important errors of translation from Arabic to Russian and vice versa and the development of treatments and tools needed by the interpreter to give the exact equivalent of the text or term who face him, then the conclusion and list of sources . The legal translation foremost translation between two languages and two legal juridical we can speak about two different legal systems. This means that the legal term predetermined legal system that belongs to him that legal term, and it cannot be understood and therefore t
... Show MoreArts acts to reduce and exclude everything that is not necessary in the delivery of meaning, especially representative performance, which is based on the intensification of the physical and vocal actions, and in drawing the dimensions of the character. And because that, the artistic staff, among others in the ministry of education, are considered the cornerstone, in the development of theatrical activities in schools, this research came to find out the extent to which teachers in primary schools, in secondary schools and artistic supervisors rely on shorthand mechanisms in the representative performance.
The current research relied on the descriptive approach, in analyzing his sample, which was deliberately chosen, Among the most imp
The reaction of 2-amino-benzothiazole with bis [O,O-2,3,O,O – 5,6 – (chloro(carboxylic) methiylidene) ] – L – ascorbic acid (L-AsCl2) gave new product 3-(Benzo[d]Thaizole-2-Yl) – 9-Oxo-6,7,7a,9-Tertrahydro-2H-2,10:4,7-Diepoxyfuro [3,2-f][1,5,3] Dioxazonine – 2,4 (3H) – Dicarboxylic Acid, Hydro-chloride (L-as-am)), which has been insulated and identified by (C, H, N) elemental microanalysis (Ft-IR),(U.v–vis), mass spectroscopy and H-NMR techniques. The (L-as am) ligand complexes were obtained by the reaction of (L-as-am) with [M(II) = Co,Ni,Cu, and Zn] metal ions. The synthesized complexes are characterized by Uv–Visible (Ft –IR), mass spectroscopy molar ratio, molar conductivity, and Magnetic susceptibility techniques. (
... Show More