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Effect of gold nanoparticles synthesis by plasma jet scheme on normal cell lines
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New evidence on nanotechnology has shown interest in the creation and assessment of nanoparticles for cancer treatment. Worldwide, a wide range of tumor-targeted approaches are being developed to reduce side effects and boost the efficacy of cancer therapy. One strategy that shows promise is the use of metallic nanoparticles to increase the radio sensitization of the cancer cells while reducing or maintaining the normal tissue complication probability during radiation therapy. In this study, atmospheric plasma was created using argon gas to create Au NPs using the plasma jet scheme, and their ability to induce apoptosis as an anticancer mechanism was tested. Aqueous gold tetrachloride salts (HAuCl4·3H2O) ere used to produce gold nanoparticles. For conformations, various techniques were used to explore the characterization of Au NPs, included UV–Vis spectroscopy, X-Ray Diffraction (XRD), Field Emission Scanning Electron Microscopy (FE-SEM),). UV–vis spectroscopy showed a maximum absorption peak located between 520 and 530 nm. The peaks of XRD 2θ are observed at 38.8°, 44.47°, 64.4° and 77.17°. They correspond to the 111, 200, 220 and 311 crystalline levels respectively. The peak intensity (111) at 38.8° diffraction was maximum peak. the image of FESEM showed that the Au NPs which produced are irregularly shaped spheres with sizes ranging between 41-46 nm. The effect of nanoparticles on REF normal cell lines was studied to calculate cytotoxicity and the greatest rate of destruction of REF normal cell lines was 22.667% after incubation time 72 hour after exposure to the combination of irradiated gold nanoparticles-cisplatin with 50 Gray photon X-ray and 1 µg of cisplatin and the minimum was 0.7% after incubation time 24 hour after exposure to the combination of irradiated gold nanoparticles-cisplatin with 0.5 Gray photon x-ray and 0.025 µg of cisplatin. Its possible to enhance chemotherapy treatment by these nanoparticles, In the future these techniques will be possible to use for kill cancer cells, especially after showed low toxicity on normal cells.

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Publication Date
Wed Mar 10 2021
Journal Name
Baghdad Science Journal
The Cytotoxic Effect of the Extract of Anchusa strigosa (Him Him) Grown in Jordan Against Different Cancer Cell Lines
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Anchusa strigosa - prickly alkanet from Boraginaceae grows in roadsides, and fields of a broad range of habitats from mediterranean woodlands, to steppe vegetation, to true desert. It is commonly known as" him him" or "lisan al thawr". Anchusa can withstand hard weather conditions and hence is widely cultivated. The color of its flowers can range from pure white to deep cobalt blue. Various parts of A. strigosa are used in traditional medicine for treating several diseases or symptoms, such as abdominal pain, bronchitis, cough, and diarrhea. The goal of this study was to examine the cytotoxic effect of the crude extract of A. strigosa roots and leaves and their fractions against various tumor cell lines: adenoc

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Publication Date
Fri Jan 26 2024
Journal Name
Iraqi Journal Of Science
Anticancer Activity of Sunflower (Helianthus annuns L.) Seeds oil against cell lines
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This study investigated the role of sunflower (Helianthus annuns L.) seed extracts as a cytotoxic agent against two cell lines (RD and L20B) using different concentrations of sunflower seeds oil 1.3 , 2.6 , 5.2, 10.4 , 20.8, 41.6 , 83.2 and 166.4 μg / ml for different exposure time (24 ,48 and 72 hrs). The results revealed a clear cytotxoic activity of sunflower seeds oil on growth of RD cancer cell line, and the effect was concentration-dependent.
The signification inhibition (P<0.05) was obtained at a concentration of 83.5 and 166.4 μg / ml as compared to control. In addition, the growth of RD cell line was more sensitive to sunflower seeds oil in comparison with the growth of L20B transform cell line. In conclusion, the extrac

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Publication Date
Wed Jul 20 2022
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Enhancement of Antibacterial Activity of Face Mask with Gold Nanoparticles
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The emergence of new dangerous diseases worldwide has led to the need to think about the possibility of enhancing prevention by using new technologies. One of the most important requirements emphasized in the recent studies is the effectiveness of the masks against pathogenic bacteria. In this study, the efficiency of anti-infection protective face masks against bacteria was enhanced by using gold nanoparticles prepared by the chemical precipitation method. The absorption spectrum of the prepared gold suspension shows a clear plasmonic peak at 522 nm. The measurements showed that the sample was made of polypropylene fibers, where X-ray diffraction tests showed peaks matching its crystalline structure. Immersion with gold suspension led t

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Publication Date
Mon Dec 05 2022
Journal Name
Baghdad Science Journal
Heavy Metal Complexes of 1, 2, 3-Triazole derivative: Synthesis, Characterization, and Cytotoxicity Appraisal Against Breast Cancer Cell Lines (MDA-MB-231)
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     New chelating ligand derived from triazole and its complexes with metal ions Rhodium, Platinum and Gold were synthesized. Through a copper (I)-catalyzed click reaction, the ligand produced 1,3-dipolar cycloaddition between 2,6-bis((prop-2-yn-1-yloxy) methyl) pyridine and 1-azidododecane. All structures of these new compounds were rigorously characterized in the solid state using spectroscopic techniques like: 1HNMR, 13CNMR, Uv-Vis, FTIR, metal and elemental analyses, magnetic susceptibility and conductivity measurements at room temperature, it was found that the ligand acts as a penta and tetradentate chelate through N3O2, N2O2, and the geometry of the new complex

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Publication Date
Mon Dec 05 2022
Journal Name
Baghdad Science Journal
Heavy Metal Complexes of 1, 2, 3-Triazole derivative: Synthesis, Characterization, and Cytotoxicity Appraisal Against Breast Cancer Cell Lines (MDA-MB-231)
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     New chelating ligand derived from triazole and its complexes with metal ions Rhodium, Platinum and Gold were synthesized. Through a copper (I)-catalyzed click reaction, the ligand produced 1,3-dipolar cycloaddition between 2,6-bis((prop-2-yn-1-yloxy) methyl) pyridine and 1-azidododecane. All structures of these new compounds were rigorously characterized in the solid state using spectroscopic techniques like: 1HNMR, 13CNMR, Uv-Vis, FTIR, metal and elemental analyses, magnetic susceptibility and conductivity measurements at room temperature, it was found that the ligand acts as a penta and tetradentate chelate through N3O2, N2O2, and the geometry of the new complexes are identified as octahedral for (Rh & Pt) complexes a

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Publication Date
Thu Oct 01 2015
Journal Name
International Journal Of Current Engineering And Technology
Synthesis of Gold Nanoparticle in the form of Paper Willow by Hot Chemical Reduction Method
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Abstract: Colloidal gold nanoparticles (ringworm Palm or in the form of paper willow) have been prepared from HAuCl4 containing aqueous solution by hot chemical reduction method. The colloidal gold nanoparticles were characterized by SEM, EDX, and UV-VIS absorption spectroscopy. It was found that the variation of reduction time from boiling point affects the size of the nanoparticles and also in chemical reduction approach the size of nanoparticles can be controlled by varying the amount of variation the volume of reductant material with respect to the volume of HAuCL4.

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Publication Date
Tue Jan 01 2019
Journal Name
Technologies And Materials For Renewable Energy, Environment And Sustainability: Tmrees19gr
Improvement photoluminescence of nematic liquid crystal doped with gold nanoparticles
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Publication Date
Sat Apr 01 2017
Journal Name
Iraqi Journal Of Cancer And Medical Genetics
Mitotic activity of cultured human lymphocytes treated with gold nanoparticles
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Potential health and environmental effects of nanoparticles need to be thoroughly assessed before their widespread commercialization. The present investigation was planned with the aims to determine the effects of gold nanoparticles (GNPs) on blast (BI) and mitotic (MI) indices of cultured lymphocytes. The results revealed that BI (50.3±2.3, 30.2±1.9, 10.5±0.7 and 0.0%, respectively) and MI (70.1±2.9, 20.4±1.1, 5.3±0.1 and 0.0%, respectively) showed a gradual decreased percentage as the concentration of GNPs was increased from 0.085 to 0.66 µg/mL, and the difference was significant compared to control culture (81.6±2.5 and 90.2±3.7%, respectively). A maximum inhibition of BI and MI was occurred at the concentration 0.66 µg/mL. In

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Publication Date
Wed Jan 09 2002
Journal Name
Journal Of Pharmaceutical Negative ResultsĀ¦ Volume
Antibacterial Improvement of Disease-Protective Face Masks Using Gold Nanoparticles
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In this work, the antibacterial effectiveness of face masks made from polypropylene, against Candida albicans and Pseudomonas aeruginosa pathogenic was improved by soaking in gold nanoparticles suspension prepared by a one-step precipitation method. The fabricated nanoparticles at different concentrations were characterized by UV-visible absorption and showed a broad surface Plasmon band at around 520 nm. The FE-SEM images showed the polypropylene fibres highly attached with the spherical AuNPs of diameters around 25 nm over the surfaces of the soaked fibres. The Fourier Transform Infrared Spectroscopy (FTIR) of pure and treated face masks in AuNPs conform to the characteristics bands for the polypropylene bands. There are some differences

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Publication Date
Sun Apr 26 2020
Journal Name
Iraqi Journal Of Science
The Antibiofilm Efficacy of Gold Nanoparticles Against Acinetobacter baumannii: none
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Acinetobacter baumannii is highly adapted to hospital environments, causing persistent chronic infections due to its ability to form biofilms. In this work, the antibiofilm activity of AuNPs with a subMIC concentration of 9.34 μg/ml was investigated by the microtiter plate method against 80 clinical isolates of A. baumannii. The results revealed that the biofilm was significantly (P< 0.05) reduced by 48.2 – 82.1%.

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