Zinc is an essential element for the body; it is involved in many enzymes and has a role in many physiological processes; glucose metabolism stands ahead of them. Also, chromium has been used recently as a food supplement in regime systems, So it's essential to evaluate the effects of these two elements in a diabetic state and evaluate their antidiabetic ability. Seventy male adult mice were used and grouped into seven groups. Group 1: received no treatment. Group 2 received 10mg/kg body weight daily orally of ZnONPs for a month. Group 3 received 1mg/kg body weight for a month daily oral of CrO3NPs. Group 4: received a single dose of 150mg/kg body weight of alloxan. Group 5 received a single alloxan dose of 150 mg/kg and daily oral 10 mg/kg body weight of ZnONPs for a month. Group 6: received a single alloxan dose of 150 mg/kg and 1mg/kg body weight for a month daily oral Cr2O3NPs. Group: received single alloxan dose 150mg/kg and 1mg/kg body weight for month daily oral of Cr2O3NPs and 10 mg/kg body weight of ZnONPs for month. Explained that there is a significant decrease in fasting blood glucose and HbAlc and a substantial increase in insulin and C-peptide levels compared with diabetic group in diabetic groups treated with one or both nanoparticle types. Histological results exhibited better diabetic degeneration effects enhancement in all diabetic groups treated with one or both nanoparticle types. In conclusion, ZnONPs and CrO3NPs exhibit a synergistic effect on diabetes improvement, and they restore the degenerated insulin-producing cells of Langerhans Islets, giving improvement parameters better than they used alone.
