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The Meshing between Epstein Barr Virus Nuclear Antigen-1 and P53 in Iraqi Malignant Breast Tissues
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In Iraq, breast cancer incidence exceeds any other type of cancers and the etiology not understood well.Epstein Barr virus is a gamma herpesviruses and one of carcinogenic viruses that may implicated tobreast carcinogenesis. The nuclear antigen-1 (EBNA-1) protein is the sole EBV antigen that presentedin all tumors related to EBV and plays pivotal roles in carcinogenesis of the virus. Examination appliedby immunohistochemistry (IHC) to detect and demonstrate the correlation between (EBNA-1) and tumorsuppressor protein (P53) expression. The study includes paraffin-embedded tissue blocks of ninety 90malignant breast tissues and thirty 30 normal breast autopsies. EBNA-1 was significantly expressed in 40/90(44.4%) of malignant tissues while its expression in normal breast tissues was negative in all tested cases.The tumor suppressor protein P53 was showed negative expression in all normal breast tissues and positivein 27/90 (30%) in malignant breast tissues. A significant negative relationship (r=-0.420; P<0.05) revealedbetween EBNA-1and P53 expression. These finding reveal that EBNA-1 was evident in malignant breasttissues and demonstrate the interplay between EBV and p53 raising the possibility that viral infection maybe involved in carcinogenesis process

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Publication Date
Fri Jun 16 2023
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
Autophagy or Apoptosis: Anticancer Molecular Mechanism of Epigallocatechin Gallate with Natural Polyphenol Effect on HepG2 Cells Viability
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Background: The anticancer impact of Epigallocatechin gallate (EGCG) the highly active polyphenol of green tea was abundantly studied.  Though, the exact mechanism of its cytotoxicity is still under investigation. Objectives: Hence, the current study designed to investigate the molecular target of EGCG in HepG2 cells on thirteen autophagy- and/or apoptosis- related genes. Methods: The apoptosis detection analyses such as flow cytometry and dual apoptosis assay were used. The genes expression profile was explored by the real-time quantitative-PCR. Results: EGCG increases G0/G1 cell cycle arrest and the real-time apoptosis markers proteins leading to stimulate apoptos

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Publication Date
Sun Oct 01 2017
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Laparoscopic Low Anterior Resection using Endo GIA Radial Reload Stapler: early results (case series)
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Background: Laparoscopic colectomy is performed in an increasing number of institutions as a minimally invasive treatment for benign and malignant large bowel disease. Laparoscopic rectal surgery enables more accurate visualization of the anatomical structure in the pelvic cavity for selected patients with tumors in the middle and low rectum.
Objectives: To determine the early outcome of patient who underwent laparoscopic low anterior resection using radial reload stapler.
Patients and methods: This is a prospective study of 8 patients with low or mid rectal cancer who underwent a laparoscopic low anterior resection between January 2017 till June 2017 at Saint Raphael hospital.
Results: Eight patients underwent elective laparosc

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Publication Date
Thu Dec 24 2020
Journal Name
Psychology And Education
A Proposed Programme Based On Sensory Integration Theory For Remediating Some Development Learning Disabilities Among Children
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The current research aims to prepare a proposed Programmebased sensory integration theory for remediating some developmental learning disabilities among children, researchers prepared a Programme based on sensory integration through reviewing studies related to the research topic that can be practicedby some active teaching strategies (cooperative learning, peer learning, Role-playing, and educational stories). The Finalformat consists of(39) training sessions.

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Publication Date
Fri Sep 01 2017
Journal Name
Global Journal Of Pure And Applied Mathematics
Solution of Modified Kuznetsov Model with Mixed Therapy
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In this paper two modifications on Kuznetsov model namely on growth rate law and fractional cell kill term are given. Laplace Adomian decomposition method is used to get the solution (volume of the tumor) as a function of time .Stability analysis is applied. For lung cancer the tumor will continue in growing in spite of the treatment.

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Publication Date
Sun Apr 30 2023
Journal Name
Iraqi Journal Of Science
Natural radioactivity Measurements of Dur-Kurigalzu's Ziggurat, Baghdad Governorate-Iraq using HPGe detector
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       Measurement of 238U, 233Th and 40K concentrations in soil samples collected from Ziggurat of Dur-Kurigalzu west region of Baghdad, have been evaluated, using high purity germanium detector. The activity concentrations of 238U, 233Th and 40K varied from 16.040  to 26.620 , 14.510  to 31.480 , and 153.820  to 266.320  with average values of 20.604±2.9 , 24.534±3.3 , 212.22±25.1 , respectively. The importance of these measurements lies in the estimation of radiation risk, radium equivalent, absorbed dose, annual effective dose, risk indices, gamma index, and cancer risk. The average value of the absorbed dose ranged from 33.187  outdoors to 63.111  indoo

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Publication Date
Thu Nov 08 2018
Journal Name
Iraqi National Journal Of Nursing Specialties
Impact of instructional intervention program upon women's psychological health status who undergo chemotherapy after mastectomy
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Objective(s): To determine the impact of instructional intervention program upon psychological health status for
women who undergo chemotherapy after mastectomy
Methodology: The sample consisted of (100) women, (50) considered as study group, and another (50) the control
group. A pre test was done for both groups (study and control), and then the study samples were exposed to an
instructional intervention and three-dimensional post tests and the length of time between each test 21 days in
the Institute and Hospital of Radiation and Nuclear Medicine. The questionnaire composed of three parts, first,
demographic information; include (age, educational level, type of family, occupation, marital status, and adequacy
of mo

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Publication Date
Thu Apr 29 2021
Journal Name
Iraqi Journal Of Science
Investigation of transition symmetry shapes of 160-168Yb nuclei using IBM
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The interacting boson models,  and  were used to perform a complete study  of even –even 160-168Yb isotopes .The low –lying positive parity states, dynamic symmetries, reduced electric quadrupole transition probability , quadruple  momentum , and potential energy surface  for 160-168Yb  were investigated. Energy level sequences and energy ratios showed the gradual transition of the properties of these nuclei from the γ-unstable features  to the rotational features . Adding the pairing parameter  to   Hamiltonian had a very slight effect on this feature, but it raised the β band, since it represents symmetry breaking such as in γ-unstable features . This applie

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Publication Date
Mon Mar 23 2020
Journal Name
Baghdad Science Journal
Surfactant Cloud Point Extraction as a Procedure of Preconcentrating for Metoclopramide Determination Using Spectro Analytical Technique
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In current article an easy and selective method is proposed for spectrophotometric estimation of metoclopramide (MCP) in pharmaceutical preparations using cloud point extraction (CPE) procedure. The method involved reaction between MCP with 1-Naphthol in alkali conditions using Triton X-114 to form a stable dark purple dye. The Beer’s law limit in the range 0.34-9 μg mL-1 of MCP with r =0.9959 (n=3) after optimization. The relative standard deviation (RSD) and percentage recoveries were 0.89 %, and (96.99–104.11%) respectively. As well, using surfactant cloud point extraction as a method to extract MCP was reinforced the extinction coefficient(ε) to 1.7333×105L/mol.cm in surfactant-rich phase. The small volume of organi

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Publication Date
Fri Sep 02 2022
Journal Name
Military Medical Science Letters
SOLID LIPID NANOPARTICLES AS A PROMISING APPROACH FOR DELIVERY OF ANTICANCER AGENTS: REVIEW ARTICLE
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Cancer disease has a complicated pathophysiology and is one of the major causes of death and morbidity. Classical cancer therapies include chemotherapy, radiation therapy, and immunotherapy. A typical treatment is chemotherapy, which delivers cytotoxic medications to patients to suppress the uncontrolled growth of cancerous cells. Conventional oral medication has a number of drawbacks, including a lack of selectivity, cytotoxicity, and multi-drug resistance, all of which offer significant obstacles to effective cancer treatment. Multidrug resistance (MDR) remains a major challenge for effective cancer chemotherapeutic interventions. The advent of nanotechnology approach has developed the field of tumor diagnosis and treatment. Cancer nanote

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Publication Date
Fri Apr 30 2021
Journal Name
Iraqi Journal Of Science
Enhanced Supervised Principal Component Analysis for Cancer Classification
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In this paper, a new hybridization of supervised principal component analysis (SPCA) and stochastic gradient descent techniques is proposed, and called as SGD-SPCA, for real large datasets that have a small number of samples in high dimensional space. SGD-SPCA is proposed to become an important tool that can be used to diagnose and treat cancer accurately. When we have large datasets that require many parameters, SGD-SPCA is an excellent method, and it can easily update the parameters when a new observation shows up. Two cancer datasets are used, the first is for Leukemia and the second is for small round blue cell tumors. Also, simulation datasets are used to compare principal component analysis (PCA), SPCA, and SGD-SPCA. The results sh

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