Background: Chronic hyperglycemia is the most frequent diabetes-related metabolic disorder because of faulty insulin action or production. According to the WHO, osteoporosis is a progressive systemic skeletal disorder that decreases bone mass and micro architecture bone tissue, increasing bone fragility and fracture risk. Nervosa damage determines how much a diabetic's body is damaged. Objective: The current work aimed to examines age, BMI, HbA1c, fasting blood glucose, sclerostin, and lipid profiles (TC, TG, HDL-C, VLDL-C, and LDL-C) in Iraqi T2DM menopausal women with /without osteoporosis to detect biomarkers in such condition. Subjects and Methods: 120 subjects were included in this study. They were divided into 3 groups; Group 1 (N = 40) consisted of seemingly healthy women, group 2 (N = 40) included type 2 diabetes patients without osteoporosis and group 3 (N = 40) included type 2 diabetes patients with osteoporosis. The patients were recruited from the Endocrinology and Diabetes Center of the Iraqi Ministry of Health in Baghdad between January and June 2022. The ages of participants ranged from 45 to 55 years. Glucose, HbA1c, sclerostin, and lipid profiles were measured. The t-test, mean, standard division, and other bio statistical approaches were used to examine the data. Results: Various data were observed in osteoporosis patients with and without T2DM in Iraqi postmenopausal women regarding Sclerostin and other anthropometric parameters and biomarkers studied. Conclusion: Type 2 diabetic Iraqi women with and without osteoporosis had significantly lower Sclerostein levels than controls. Sclerostin correlates with BMI, HbA1c, FBG, and lipid profile (TC, TG, HDL-C, VLDL-C and LDL-C). Keywords: T2DM, Sclerostin, Osteoporosis, HDL-C, BMI
Study aimed to determination of chitotriosidase-1 levels in Iraqi diabetic and diabetic patients with thyroid disorder. Also, study aimed to found relation correlation for chitotriosidase-1 with FSG, T3, T4 and TSH. Ninety subjects were including in this study. First group consisted of (30) healthy individuals who have no history of any thyroid disorders or diabetes mellitus as control group. Second group (G2) (n=30) patients with diabetic and hyperthyroidism as association disease, and third group (G3) (n=30) include patients with diabetic and hypothyroidism as association disease. Serum used in (FSG, T3, T4, TSH, and Chitotriosidase-1) determination. Results showed a significant elevation in patients’ groups (G2, G3) comparing t
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Background: Breast cancer (BC) is a type of cancer originating from breast tissue, Lipid profile seems to influence the development of female breast cancer, especially in the presence of an increased body mass index so.
Objective: to explore the status of lipid profile in women with breast cancer.
Subjects and methods: the present study is a cross-sectional study (2010/2011) done at Al-Yarmouk Teaching Hospital. Includes measurement of LP in sera of postmenapausal newly diagnosed women with BC in comparison with healthy control women. This measurement was done using colorimetric method. In The results of this study include a total of 100 patients with BC were involved in this study, they were classified as newly diagnosed postmenop
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Background:
type 2 diabetes mellitus is a chronic disease that is accompanied by the production of free radicals which will ultimately increase the level of oxidative stress.
The present study aimed to look for the differences in the oxidative stress status in sera and saliva samples of type 2 diabetic Iraqi patients with and without proliferative diabetic retinopathy. As well as to look for the possibility whether this status can be measured in saliva as an alternative sample to that of serum, hence to achieve that total oxidant status, total antioxidant status and oxidative stress index were measured in both sera and saliva samples of two groups of patients with type 2 diabetes mellitus and the healthy individuals. Upon the comparison between patients without proliferative diabetic retinopathy and the control sample the results showed presence of a significant increase (p < 0.05) of total oxidant st
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Background: Several studies suggested that skeletal system is adversely affected by diabetes and is associated with increased risk of osteoporosis and fragility fractures
Objectives: The study was a case-control study that designed to assess the level of bone turnover markers (BTMs) among patients with type 2 diabetes mellitus (T2DM) and to investigate the effect of body weight and diabetic control on the level of bone turnover
Type of the study: Cross- sectional study.
Methods: The present study included 100 postmenopausal women with type 2 diabetes mellitus. Sixty-six non-diabetic postmenopausal women were enrolled as a control. Fasting b
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Comparative Study Between Glimepiride and Glibenclamide in the Treatment of Type 2 Diabetic Patients in Al-Yarmouk Hospital
Background: The accumulation of the lipid in the vascular smooth muscle cell within the arterial intima is a key process of the pathogenesis of atherosclerosis. Atherosclerosis is a degenerative disease of blood vessels leading to stroke.
Materials & Methods.One hundred and ten patients with acute stroke were included in this study 88 patients with ischaemic or infarction stroke and 22 patients with hemorrhagic type ) as well as thirty apparently normal healthy subjects as controls.
Results.Triglycerides levels and AI only were statistically significant in ischaemic type of stroke (P<0.005) while other lipid fractions were similar to the control values.
Conclusion: Acute stroke patients (infarction type) had significantly
Diabetes is a complex set of diseases require continuous medical care, to control blood sugar and prevent complications is .The aim of this research is to determine the effect of administration of L carentin to diabetics on the lipid profile. The research was conducted on sixty diabetic patients were selected from endocrinology and diabetes center / Al-Rusafa, within selected criteria. The patients divided into 3 groups (control group of healthy people and two groups of patients with diabetes who were on metformin and glibenclamide, one group took a L carnitine in a dose of 1000 mg twice daily and a group dealing with a placebo for a period of 3 months continuously). The study found that patients who took Lc
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This study aims to investigate the relationship between thyroid peroxidase antibody (TPO) and thyroid function tests (TSH, T3 and T4) in patients with type 2 diabetes mellitus (T2DM). Ninety women and men, with ages ranging between 35-65 years and weighing 60-80 kgs, were selected for this study. They were classified into three groups: G1 included 15 healthy control group, G2 had15 patients with T2DM and G3 had 60 patients with T2DM and hypothyroidism. Blood samples were collected from each individual via vein puncture to assess thyroid hormone and TPO-Ab. The results showed highly significant (p < 0.01) increase in TSH level in the diabetic group with hypothyroidism when compared to the other groups. There was no significant
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Background: New data suggests that joint damage in Knee Osteoarthritis (KOA) may be caused by systemic factors like adipose tissue products; Adipokines, which may provide a
metabolic link between obesity & KOA. Recently, one of the known adipokines named LEPTIN has been linked to KOA because it can be detected in serum & synovial fluid of
patients with KOA.
Objective: To evaluate the contribution of Leptin & serum lipids to the pathophysiology of Osteoarthritis in Iraqi patients with Knee OA.
Subjects& Methods: The study was carried on 90 subjects divided into four groups: Knee Osteoarthritis cases group (n=60). Control group (n=30). Obese subjects group (n=60).
Non-obese subje