Background The Transportation Problem (TP) is a detailed model in operations study with applications in logistics, supply chain management, and resource allocation. The classical IBFS methods including North-West Corner, Least Cost and Vogel’s Approximation have competitive computational efficiency, but they are very sensitive to the structure of the problem and usually lead to a solution that is far from the global optimum. Classic enhancement strategies like the Generalized Distribution (MODI) and Stepping-Stone (SS) approaches have low computational complexity but may fall into a local optimum quickly, which makes them ineffective in large-scale or unbalanced problems. Methods We propose the first generic hybrid algorithm, called Ester Hybrid Improvement for Transportation Problem (EHITP), which was developed with the aim of mitigating the shortcomings of traditional IBFS-based methods. To overcome the local minima problem, the proposed EHITP framework combines adaptive perturbation procedures and guided neighborhood search methodologies to broaden the solution space. Results Initial experiments on benchmark and synthetically created datasets show that EHITP obtains a much less total transportation cost relative to the classical IBFS and improved MODI/SS methods. These features lead to a more robust method, stable solutions over iterations, and convergence across a wider range of problem sizes and structures. Conclusions The findings show EHITP serves as a more reliable, scalable, and expense-effective solution to transportation issues. The balance this algorithm achieves between the quality of the solution it produces, and its computational efficiency makes it a potential candidate for real life applications in topics such as distribution chain and economic resource allocation.
A comparative investigation of gas sensing properties of SnO2 doped with WO3 based on thin film and bulk forms was achieved. Thin films were deposited by thermal evaporation technique on glass substrates. Bulk sensors in the shape of pellets were prepared by pressing SnO2:WO3 powder. The polycrystalline nature of the obtained films with tetragonal structure was confirmed by X-ray diffraction. The calculated crystalline size was 52.43 nm. Thickness of the prepared films was found 134 nm. The optical characteristics of the thin films were studied by using UV-VIS Spectrophotometer in the wavelength range 200 nm to 1100 nm, the energy band gap, extinction coefficient and refractive index of the thin film were 2.5 eV , 0.024 and 2.51, respective
... Show MoreElectronic properties such as density of state, energy gap, HOMO (the highest occupied molecular orbital) level, LUMO (the lowest unoccupied molecular orbital) level and density of bonds, as well as spectroscopic properties like infrared (IR), Raman scattering, force constant, and reduced masses for coronene C24, reduced graphene oxide (rGO) C24O5and interaction between C24O5and NO2gas molecules were investigated. Density functional theory (DFT) with the exchange hybrid function B3LYP with 6-311G** basis sets through the Gaussian 09 W software program was used to do these calculations. Gaussian view 05 was em
... Show MoreAsthma is a chronic inflammatory disease of airways mediated by T-helper 2 (Th2) cells involving complex signaling pathways. Although resveratrol has previously been shown to attenuate allergic asthma, the role of miRNA in this process has not been studied. We investigated the effect of resveratrol on ovalbumin-induced experimental allergic asthma in mice. To that end, BALB/c mice were immunized with ovalbumin (OVA) intraperitoneally followed by oral gavage of vehicle (OVA-veh) or resveratrol (100 mg/kg body) (OVA-res). On day 7, the experimental groups received intranasal challenge of OVA followed by 7 days of additional oral gavage of vehicle or resveratrol. At day 15, all mice were euthanized and bronchioalveolar fluid (BALF), se
... Show MoreBackground: The roles of AI in the academic community continue to grow, especially in the enhancement of learning outcomes and the improvement of writing quality and efficiency. Objectives: To explore in depth the experience of senior pharmacy students in using artificial intelligence for academic purposes. Methods: This qualitative study included face-to-face individual interviews with senior pharmacy students from March to May 2023 using a pre-planned interview guide of open-ended questions. All interviews were audio-recorded. Thematic analysis was used to analyze the data. Results: The results were obtained from 15 in-depth face-to-face interviews with senior pharmacy students (5th and 4th years). Eight participants were male, an
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