Lasmiditan (LAS) was formulated as a nanoemulsion based in situ gel (NEIG)with the aim of improving its oral bioavailability via application intranasally. The solubility of LAS in oils, emulsifiers, and co-emulsifiers was determined to identify nanoemulsion (NE)components. Phase diagrams were constructed to identify the area of nanoemulsification. LAS NE was formulated using the spontaneous nanoemulsification method. Four NEs (F19, F24, F31, and F34) containing 7-15 % oleic acid (OA) as an oily phase, 40-55% labrasol (LR), and transcutol (TC) as emulsifier mixture at (1:1), (2:1), (3:1), and (1:2) ratio with 30-53 % (w/w) aqueous phase, having suitable optical transparency of 95–98%, globule size of 104-140 nm and polydisper

The intelligent buildings provided various incentives to get highly inefficient energy-saving caused by the non-stationary building environments. In the presence of such dynamic excitation with higher levels of nonlinearity and coupling effect of temperature and humidity, the HVAC system transitions from underdamped to overdamped indoor conditions. This led to the promotion of highly inefficient energy use and fluctuating indoor thermal comfort. To address these concerns, this study develops a novel framework based on deep clustering of lagrangian trajectories for multi-task learning (DCLTML) and adding a pre-cooling coil in the air handling unit (AHU) to alleviate a coupling issue. The proposed DCLTML exhibits great overall control and is

     Elliptic Curve Cryptography (ECC) is one of the public key cryptosystems that works based on the algebraic models in the form of elliptic curves. Usually, in ECC to implement the encryption, the encoding of data must be carried out on the elliptic curve, which seems to be a preprocessing step. Similarly, after the decryption a post processing step must be conducted for mapping or decoding the corresponding data to the exact point on the elliptic curves. The Memory Mapping (MM) and Koblitz Encoding (KE) are the commonly used encoding models. But both encoding models have drawbacks as the MM needs more memory for processing and the KE needs more computational resources. To overcome these issues the proposed enhanced Koblitz encodi

     Today, the use of iris recognition is expanding globally as the most accurate and reliable biometric feature in terms of uniqueness and robustness. The motivation for the reduction or compression of the large databases of iris images becomes an urgent requirement. In general, image compression is the process to remove the insignificant or redundant information from the image details, that implicitly makes efficient use of redundancy embedded within the image itself. In addition, it may exploit human vision or perception limitations to reduce the imperceptible information.
     This paper deals with reducing the size of image, namely reducing the number of bits required in representing the