This study expands the state of the art in studies that assess torsional retrofit of reinforced concrete (RC) multi-cell box girders with carbon fiber reinforced polymer (CFRP) strips. The torsional behavior of non-damaged and pre-damaged RC multi-cell box girder specimens externally retrofitted by CFRP strips was investigated through a series of laboratory experiments. It was found that retrofitting the pre-damaged specimens with CFRP strips increased the ultimate torsional capacity by more than 50% as compared to the un-damaged specimens subjected to equivalent retrofitting. This indicated that the retrofit has been less effective for the girder specimen that did not develop distortion beforehand as a result of pre-loading. From experimental observations, when the girder specimen was cracked and the transverse steel reinforcement bars started straining, the CFRP strips started to work more effectively and contributed together with the transverse steel reinforcement to resist torsion load. Additionally, Finite Element (FE) simulations were developed using Abaqus to model the torsional behavior of the retrofitted girders, the results of which were validated with the experimental data. With the numerical model, the effect of concrete compressive strength, transverse reinforcement spacing, and CFRP strip spacing were examined. The effectiveness of the CFRP strips in enhancing the torsional strength of the girder was found to increase with increasing the spacing between the transverse reinforcement.