Preferred Language
Articles
/
lRcCBo4BVTCNdQwCTy_c
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells
...Show More Authors
Abstract<p>Regulatory T (Treg) cells are one of the major immunosuppressive cell types in cancer and a potential target for immunotherapy, but targeting tumor-infiltrating (TI) Treg cells has been challenging. Here, using single-cell RNA sequencing of immune cells from renal clear cell carcinoma (ccRCC) patients, we identify two distinct transcriptional fates for TI Treg cells, Fate-1 and Fate-2. The Fate-1 signature is associated with a poorer prognosis in ccRCC and several other solid cancers. CD177, a cell surface protein normally expressed on neutrophil, is specifically expressed on Fate-1 TI Treg cells in several solid cancer types, but not on other TI or peripheral Treg cells. Mechanistically, blocking CD177 reduces the suppressive activity of Treg cells in vitro, while Treg-specific deletion of <italic>Cd177</italic> leads to decreased tumor growth and reduced TI Treg frequency in mice. Our results thus uncover a functional CD177<sup>+</sup> TI Treg population that may serve as a target for TI Treg-specific immunotherapy.</p>
Scopus Clarivate Crossref
View Publication
Publication Date
Sat Feb 01 2020
Journal Name
Energy Reports
Study of photoemission and electronic properties of dye-sensitized solar cells
...Show More Authors

We have investigated the photoemission and electronic properties at the PTCDI molecules interface on TiO2 and ZnO semiconductor by means of charge transition. A simple donor acceptor scenario used to calculate the rate for electron transfer of delocalized electronics in a non-degenerately TiO2 and ZnO electrodes to redox localized acceptors in an electrolytic. The dependent of electronic transition rate on the potential at contact of PTCDI with TiO2 and ZnO semiconductors, it has been discussion using TiO2 and ZnO electrodes in aqueous solutions. The charge transfer rate is determining by the overlapping electronic coupling to the TiO2 and ZnO electrodes, the transition energy, potential and polarity media within the theoretical scenario of

... Show More
View Publication Preview PDF
Crossref (6)
Crossref
Publication Date
Fri Jan 01 2021
Journal Name
E3s Web Of Conferences
Behavioral Investigation of Reinforced Concrete T-Beams with Distributed Reinforcement in the Tension Flange
...Show More Authors

Current design codes and specifications allow for part of the bonded flexure tension reinforcement to be distributed over an effective flange width when the T-beams' flanges are in tension. This study presents an experimental and numerical investigation on the reinforced concrete flanged section's flexural behavior when reinforcement in the tension flange is laterally distributed. To achieve the goals of the study, numerical analysis using the finite element method was conducted on discretized flanged beam models validated via experimentally tested T-beam specimen. Parametric study was performed to investigate the effect of different parameters on the T-beams flexural behavior. The study revealed that a significant reduction in the

... Show More
View Publication
Scopus (3)
Crossref (3)
Scopus Crossref
Publication Date
Fri Jan 26 2024
Journal Name
Iraqi Journal Of Science
Influence The Effectiveness of Compounds Produced From Algae Oscllatoria Princeps Agains t Bacteria and Detected of Some Fatty Acids
...Show More Authors

In this study Oscillatoria princeps were isolated ،purified and identification
from water canal in Almustansiriah University . BG-11 culture media was used for
their cultivation in suitable laboratory conditions (25c°, 200μE/mP
2
P/sec) for 16:8 hrs.
Light: dark. Each culture was harvested at the end of exponential phase .Organic
solvents used for extraction was Chloroform: methanol at 2:1 to extract the crude
active Intracellular and Extracellular substances, and evaporated down to dryness.
Antibacterial activity of these different extracts were evaluated against 10 strains of
gram positive bacteria and gram negative bacteria, Agar diffusion method was used
in this evaluation. Results showed that the int

... Show More
View Publication Preview PDF
Publication Date
Sun May 10 2020
Journal Name
Baghdad Science Journal
Characterization of Mannitol Fermenter and Salt Tolerant Staphylococci from Breast Tumor Biopsies of Iraqi Women
...Show More Authors

The emergence of staphylococci, either coagulase negative (CNS) or coagulase positive (CPS), as important human pathogens has implied that reliable methods for their identification are of large significance in understanding the diseases caused by them. The identification and characterization of staphylococci from biopsies taken from human breast tumors is reported here. Out of 32 tissue biopsies, a total of 12 suspected staphylococci grew on mannitol salt agar (MSA) medium, including 7 fermenters and 5 non-fermenter staphylococci based on traditional laboratory methods. Polymerase chain reaction (PCR) successfully identified seven isolates at the genus level as methicillin resistant Staphylococcus spp. by targeting a common region of the me

... Show More
View Publication Preview PDF
Scopus Clarivate Crossref
Publication Date
Sun May 10 2020
Journal Name
Baghdad Science Journal
Characterization of Mannitol Fermenter and Salt Tolerant Staphylococci from Breast Tumor Biopsies of Iraqi Women
...Show More Authors

         The emergence of staphylococci, either coagulase negative (CNS) or coagulase positive (CPS), as important human pathogens has implied that reliable methods for their identification are of large significance in understanding the diseases caused by them. The identification and characterization of staphylococci from biopsies taken from human breast tumors is reported here. Out of 32 tissue biopsies, a total of 12 suspected staphylococci grew on mannitol salt agar (MSA) medium, including 7 fermenters and 5 non-fermenter staphylococci based on traditional laboratory methods. Polymerase chain reaction (PCR) successfully identified seven isolates at the genus level as methicillin resistant St

... Show More
View Publication Preview PDF
Scopus Clarivate Crossref
Publication Date
Sat Jun 01 2019
Journal Name
2019 International Engineering Conference (iec)
Assessment of Specific Absorption Rate and Temperature in the Tumor Tissue Subjected to Plasmonic Bow-Tie Optical Nano-Antenna
...Show More Authors

View Publication
Scopus (6)
Crossref (3)
Scopus Crossref
Publication Date
Mon Oct 30 2023
Journal Name
Iraqi Journal Of Science
Evaluating the levels of Tumor Necrosis Factorα-, Interleukin-6 and Vascular endothelial growth factor in patients with Colorectal Cancer
...Show More Authors

     Cytokines are polypeptides with several functions that are produced by a variety of bodily cells. They are clinically significant for illness diagnosis, treatment, and prevention. Interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) are the most important cytokines for cell division and proliferation. Vascular endothelial growth factor (VEGF) is produced in excess in mesenchymal, epithelial, and especially in tumor cells. In this study the serum levels of IL-6, TNF-α and VEGF were detected for 41 colorectal cancer patients and 41 healthy control group at Nanakaly Hospital by comparing their serum concentrations for patients paining from colorectal carcinoma (CRC) with those of the control subjects. The result shows a s

... Show More
View Publication Preview PDF
Scopus Crossref
Publication Date
Sun Nov 01 2020
Journal Name
Iscience
Identification and Characterization of Highly Fluorescent Pigment Cells in Embryos of the Arabian Killifish (Aphanius Dispar)
...Show More Authors

View Publication
Scopus (6)
Crossref (5)
Scopus Clarivate Crossref
Publication Date
Fri Nov 24 2023
Journal Name
Iraqi Journal Of Science
Amplification and cloning the gene of bovine leukocyte α-A-interferon in cells of Escherichia Coli
...Show More Authors

Interferon’s plays a role in innate immune responses through upregulation of costimulatory molecules and induction of proinflammatory cytokines. Interferon alpha (IFN α) type of Interferons. The present study characterized IFNα cDNA . The interferon’s play a great role in protection from infections, caused by microorganisms, and have powerful antiproliferative and immunomodulation activity. In this study DNA was isolated from bovine blood leukocyte, which was used in the quality of matrix for amplification of α-interferon gene with the use of PCR, and isolation of gene α-interferon and transformation in vector pUC18 and expression vector pET24b (+). All plasmids contained an additional DNA fragment size corresponding to the gene

... Show More
View Publication Preview PDF
Publication Date
Tue Jan 30 2024
Journal Name
Iraqi Journal Of Science
The Effect of Doped TiO2 Layer on the Performance and Stability of PCDTBT: PCBM-based Organic Solar Cells
...Show More Authors

     Charge extraction layers play a crucial role in developing the performance of the inverted organic solar cells. Using a transparent metal oxide with appropriate work function to the photoactive layer can significantly decrease interface recombination and enhance charge transport mechanism. Therefore, electron selective films that consist of aluminium-doped titanium dioxide (TiO2:Al) with different concentrations of Al (0.4, 0.8, and 1.2)wt %  were prepared using sol-gel technique. The inverted organic solar cells PCPDTBT: PCBM with Al doped TiO2 as electron extraction layer were fabricated. It is well known that Al doping concentration potentially affects the physical characteristics of the TiO2 by control

... Show More
View Publication Preview PDF
Scopus (1)
Scopus Crossref