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Serum Leptin levels in ovarian polycystic disease and its correlation to body weight

Background: Poly cystic ovary syndrome is a common disorder in women of reproductive age, it is associated with disturbance of reproductive, endocrine and metabolic functions. The pathophysiology of PCOS appears to be multifactorial and polygenic. Leptin seems to play an important role in pathophysiology of PCOS especially in women with BMI ≥25kg/m2. Objectives: To assess leptin level in both PCOS and healthy women and explore the relation to their body weight and body mass index. Patient and Methods: A total of 120 women were enrolled in this study, 60 women (50%) had PCOS (study group) and the reminder 60 women (50%) were healthy women and considered as control group. BMI was calculated first. Both groups were further subdivided into two groups; BMI of ≥25kg/m2 and BMI of <25kg/m2. Pelvic U/S scan was done to confirm the diagnosis. Hormonal profile (FSH, LH, LH/FSH, testosterone, TSH, T4 and prolactin) were measured. RBS was measured. Serum leptin level was measured in patient with PCOS and the control by Enzyme linked immunesorbant assay (ELISA) test. Correlations between leptin levels and age, Wt, Ht, BMI, and serum hormone levels (FSH, LH, testosterone and prolactin) were studied. Results: Mean serum leptin levels were not significantly higher in patients with PCOS compared to the control group (P =0.052). Leptin levels were found to be higher significantly in the overweight subgroups both in patients with PCOS and in the control women. Leptin levels were found to be higher in over weight patients with PCOS compared to over weight control P value =0.0001. Serum leptin levels were significantly correlated with BMI in both patient with PCOS and control group (r=0.918 and r=0.846) respectively. Serum leptin concentration had a positive correlation with serum LH concentration in PCOS group (r=0.327). Leptin levels had strong positive correlation with serum LH, FSH, and testosterone in over weight PCOS subgroup women and (r=0.592, 0.609 and 0.604) respectively. Conclusion: Leptin levels are higher in patient with PCOS compared to control groups. Leptin levels were correlated with the amount of fatty tissue not only in PCOS group but also in healthy women. Leptin play an important role in pathophysiology of PCOS of women with BMI ≥25 kg/m2.

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Publication Date
Wed Dec 30 2015
Journal Name
Al-kindy College Medical Journal
Cystatin (C) and its correlation to ischemic heart disease

Background: Cystatin C is recently considered to be a good predictor of cardiovascular morbidity and mortality in patients with coronary artery disease (CAD)Objectives: Correlation between cystatin and ischemic heart disease.Methods :One hundred forty patients (140) with ischemic heart disease admitted to thin study at Baghdad teaching hospital from the period June. 2011 to Jan. 2012. Those patients was categorized into three groups.Group (A): patients with ischemic heart failure.Group (B): Patients with myocardial infarction.Group (C) patients with unstable angina.All these groups were in comparison to fifty (50) healthy controls. Fasting serum citation (C) were measured in all patients and control in addition to all other routine inves

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Publication Date
Sun Sep 02 2018
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Assessment of Serum Vitamin D Levels in Women with Polycystic Ovary Syndrome

Background: Polycystic ovary syndrome (PCOS) is a common endocrinopathy in women of
reproductive age with primary features of infertility, menstrual irregularity, and clinical or biochemical
evidence of hyperandrogenism (hirsutism, acne and high androgen level). Vitamin D has a role in the
development of metabolic and endocrine abnormalities in PCOS mediated by insulin resistance.
Objective: Measure serum 25-hydroxy vitamin D levels in women with polycystic ovary syndrome and
compare their levels with age and body mass index matched healthy controls. Also, assess the
correlation between insulin resistance and 25-hydroxy vitamin D among women with PCOS.
Subjects and Methods: Eighty eight women were involved in this st

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Publication Date
Mon Jan 01 2024
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Association of Neuregulin-4 levels and body mass index with hyperandrogenism in Polycystic Ovary Syndrome patients

Background: Polycystic Ovary Syndrome (PCOS) is a common endocrine and metabolic disease that affects approximately 15% of women of childbearing age worldwide. It is one of the causes of infertility and is characterized by hirsutism, acne, persistent or interrupted anovulation, and hyperandrogenemia. Neuregulin-4 (NRG-4) is an adipokine hormone from the protein neuregulin family. Its level is greater in PCOS than in control women, and Neuregulin-4 is linked to body fat percentage and liver fat, as well as insulin resistance (IR).

Objectives: To estimate the serum NRG-4 levels in women diagnosed with (PCOS), to compare it with, non-PCOS healthy control and to explore the effect of hyperandrogenism on the obtained r

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Publication Date
Tue Jun 30 2015
Journal Name
Al-kindy College Medical Journal
Serum anti-Mullerian hormone level as a marker of polycystic ovarian syndrome in Iraqi women

Background: Polycystic ovarian syndrome is one of the common gynaecological diseases encountered nowadays in the gynaecological clinic. Many criteria and diagnostic test had been evolved to be used with different classifications methods.Objectives: The present study aimed to measure the anti-mullerian hormone levels in serum of the women with Polycystic Ovary Syndrome and to test the possibility that if it can be used as a marker for diagnosis of polycystic ovary syndrome patients.Methods: A cross sectional study that had been conductedat Kamal AL-Samaraee Hospital, AL-Suwayrah Hospital andAl-Elwiya Maternity Teaching Hospital during the periodfrom July, 1st, 2013 – Jan. 1st, 2014. Where forty women withPolycystic ovarian syndrome (wit

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Publication Date
Sat Apr 01 2017
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
Gender Differences of Serum Leptin Hormone Levels in Iraqi Population

  

To evaluate and compare serum Leptin hormone level between Iraqi male & female and the relation between this hormone & BMI in these two groups.

A total of 44 normal male & female subjects were included in this study

{Group 1 : 22 female } , { Group 2 : 22 male}.

Serum Leptin hormone ,BMI &fasting blood glucose were measured for both groups.

   Serum Leptin level in group 1 was (8.82 + 2.9 μg/L) where as in group 2 it was (4.65 + 3.2 μg/L) . These changes were statistically significant. Fasting blood glucose levels were technically within the normal value (

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Publication Date
Sun Jan 30 2022
Journal Name
Iraqi Journal Of Science
Effects of Vitamin D Deficiency in Polycystic Ovarian Syndrome

    Polycystic ovary syndrome is a very common cause of female infertility. This study aims to assess the prevalence of vitamin D deficiency and its association with clinical and anthropometric characteristics of Iraqi women with and without polycystic ovary syndrome. Fifty eightwomen with the disease and their matched control group were included. Their blood pressure was measured. Serum level of 25 hydroxy vitamin D of <20 ng/mL was graded as vitamin D deficiency. The polycystic ovary syndrome group had significantly lower levels of 25 hydroxy vitamin D, higher body mass index, and higher waist to hip ratio in contrast to the control group. The difference in body mass index was more significant in the obese category. W

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Publication Date
Sat Jun 19 2021
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
Alteration of Serum Immunoglobulin Levels in Woman with Ovarian Cancer

Ovarian cancer has a high mortality and delayed diagnosis. Several immunological alterations take place during ovarian carcinogenesis, and can be of value in the surveillance of the diseases. This research was conducted to evaluate serum immunoglobulin levels in women with ovarian cancer and to assess their role in disease process. The present study is composed of 85 women (mean age = 62.03±12.4 yrs) with clinically and pathologically confirmed ovarian cancer and 65 healthy females as a control group (mean age = 61±12.1 yrs). ELISA test was achieved for the determination of serum [IgG, IgA, IgM]. The findings of current study illustrated significant (P=0.001) increase in serum IgG, IgA, and IgM levels as compared to co

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Publication Date
Wed Jul 01 2009
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Serum resistin levels, and other hormonal and biochemical parameters in patients with polycystic ovary syndrome (PCOS)

Background: Polycystic ovarian syndrome (PCOS) is one of the most common cause of anovulation during reproductive life.Resistin can increase ovarian androgen production by directly stimulating ovarian theca cell or indirectly by augmenting pancreatic – B cell production of insulin.
Patients and Methods: Sixty patients with PCOS who were non diabetic and not taking any medicine for the last three months were involved in the study .Thirty normal fertile female serves as control group. Fasting blood samples were aspirated from all individuals from 3rd - 6th day of the menstrual cycle to measure resistin, insulin, glucose, LH, FSH, TT3, TT4, Prolactin , Total Testosterone and lipid profile, by ELISA and rou

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Publication Date
Thu Jun 02 2022
Journal Name
Neuroquantology
The effect of the relationship of leptin hormone and live body weight on some chemical characteristics of the blood serum of local laying hens

The study was conducted out at the Ministry of Agriculture's Poultry Research Station/Animal ResourcesDepartment/Agricultural Research Center. To see how body weight (BW) and leptin hormone (LEP) levels inbreeder blood affect fertility and hatchability. 140 Iraqi local laying chickens (120 females + 20 males) aged 28weeks were used in the study. Following the numbering of The experiment was divided into three periods,each lasting 28 days, during which the breeder's live body weight was recorded and divided into two categories(greater than 1.5 kg and less than 1.5 kg), and blood samples were collected at the end of each period todetermine the concentration of leptin hormone in the breeders' blood. For comparison between mothers'performance,

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Publication Date
Tue Jan 01 2013
Journal Name
Baghdad Science Journal
Detection of Type 2 Diabetes Mellitus in Serum from Women with Polycystic Ovarian Syndrome

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorder. To determine the metabolic disorders in women with PCOS, (25) women with PCOS ages (15 - 47) years have been investigated and compared with (20) healthy individuals. All the studied groups were carried out to measure fasting blood sugar, (anti-GAD Ab, anti β-islet cell Ab by IFAT) and measured insulin level by ELISA. There was significant elevation in the concentration of fasting blood sugar than in control groups (p ≤ 0.05) and there was negative results for anti-GAD Ab and anti β-islet cell Ab by IFAT test for serum of women with PCOS, while there was significant differences in the insulin level for women with PCOS compared with control groups (p ≤ 0.05),

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