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Ischemic stroke is a significant cause of morbidity and mortality worldwide. Autophagy, a
process of intracellular degradation, has been shown to play a crucial role in the pathogenesis of ischemic
stroke. Long non-coding RNAs (lncRNAs) have emerged as essential regulators of autophagy
in various diseases, including ischemic stroke. Recent studies have identified several lncRNAs that
modulate autophagy in ischemic stroke, including MALAT1, MIAT, SNHG12, H19, AC136007. 2,
C2dat2, MEG3, KCNQ1OT1, SNHG3, and RMRP. These lncRNAs regulate autophagy by interacting
with key proteins involved in the autophagic process, such as Beclin-1, ATG7, and LC3. Understanding
the role of lncRNAs in regulating auto
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