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Background:
Parkinson's
disease
(PD) is
a
neurodegenerative aging disease, with idiopathic PD
being most common. Gastrointestinal tract disorders
(GITD) and microbiota changes may trigger idiopathic PD.
Neurotoxins from microbiota can travel from the gut to the
brain via the brain-gut axis (BGA), leading to α-syn protein
misfolding and dopaminergic neuron death. Methods: The
aim of the current study was to investigate the link
between PD and GITD by measuring several biochemical
and immunological markers in 142 patients. The
biochemical markers measured were vitamins B6, B12, and
D, calcium, serotonin, ghrelin, dopamine, and α-syn
protein.
The
immunological
markers
included
transforming growth factor-beta (TGF-β), tu
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