The phenomenon of substitution is one of the morphological phenomena mentioned in the Qur'an, where the researcher defined this phenomenon from the morphological and linguistic points of view and mentioned examples of it by citing references and sources
Atorvastatin calcium (ATR) is an antihyperlipidemic agent used for lowering blood cholesterol levels. However, it is very slightly soluble in water with poor oral bioavailability, which interferes with its therapeutic action. It is classified as a class II drug according to Biopharmaceutical Classification System (low solubility and high permeability).