Checkpoint inhibitors are a type of immune therapy used to treat different types of cancers. These drugs block different checkpoint proteins, for example, CTLA-4, PD-1, and PD-L1 inhibitors.

They block proteins that stop the immune system from attacking the cancer cells.  Checkpoints are also described as a type of monoclonal antibody that antagonizes binding between B7 to CTLA-4 and PD-L1 to PD-1.

 Immune checkpoint inhibitors are used to treat BARCA mutated triple-negative breast cancer (TNBCS) in patients who do not respond to chemotherapy, and also in the treatment of highly mutated and solid tumors such as brain tumors, liver, and pancreatic cancers.

Immune checkpoint inhibitors exhibit an effect on solid tumo

Accurate pore and fracture pressure detection is a major step in successful drilling operations design. The overestimation of these parameters absolutely leads to serious problems throughout and after well drilling. This study is concerned with the characterization and analysis of the most significant diagenetic processes that degrade or improve the reservoir characteristics of the Mauddud Formation in the Badra oil field. The primary goal of this research is to estimate the pore pressure and fracture pressure using well logging data by Techlog 2015 software in order to assess the impact on the estimation of the mud weight window (MWW). The estimated values of formation pressures are then analyzed according to different diagenetic p

Arcology is a new vision of urban design for densely populated settlements. It is referred to as the urban formation aimed at achieving the highest level of utilization in the least area of land to reduce human impact on the environment. Moreover, the integration of this formation with the environment will work to reduce energy consumption, and achieve an economy that is characterized by adaptation and self-sufficiency, leading towards sustainable urbanism. The current study deals with this new concept in sustainable urban design, in an attempt to investigate its impact on traditional urban formation and to make a comparison between them. The lack of a clear conception of the term ‘arcology’ and comparing it with the organic compact urb

أهمية البحث والحاجة اليه :

الحمد لله رب العالمين القائل (( وانك لعلى خلق عظيم )) (سورة القام :4)  وصلى الله وسلم وبارك على نبينا محمد القائل " انما بعثت لأتمم مكارم الاخلاق " مسند احم: رقم الحديث 8595.

ان الاهتمام بالمشكلات السلوكية من اهم ركائن التربية والتعليم وتأتي تأتي اهميتها من ان التعيم يعين التغيير في سلوك الفرد نحو الافضل تحت تأثير الظروف والخبرات والمعارف والمهارات ال

The research in the linguistic structures of the historians Al-Yaqoubi is considered a model of the important topics in historical studies in general, given its importance in the lives of peoples due to its connotations and meanings that summarize interpretation, clarification, and prolonged speech, as it includes life meanings with many dimensions, these structures have been used in historical incidents Important, and throughout the different ages, as it can be used to support an opinion, solve problems, prove evidence, increase wisdom, and it needs rich life experiences, and a sound language, to use it, and needs a wide absorptive capacity for the recipient, the research included linguistic structures in the achievement of science , Lingu

In every age there are few great who are able to hold the burden of understanding and explaining heavenly messages . those who are immortalized by their deed troy haut history are less . the  al-emam - musa abin jaafer – peace by upon him- is one of them by his science , mentality and religion

Statistical studies are reported in this article for an active galactic nuclei sample of different type of active galaxies Seyferts 1, Seyferts 2, and Quasars. These sources have been selected from a Catalogue for bright X-ray galaxies. The name of this index is ROSAT Bright Source Catalogue (RBSC) and the NRAO VLA Sky Survey (NVSS). In this research, multi-wavelength observational bands Radio at 1.4 GHz, Optical at 4400 A⁰, and X-ray at energy 0.1-2.4 KeV have been adopted in this study. The behavior of flux density ratios has been studied ,  with respect to the absolute magnitude . Furthermore, the Seyfert1 and Seyfert 2 objects are combined in one group and the QSOs are collectest in another group. Also, it has been fo

There are a lot of takes care of the legacy of the household (p) and from different Islamic sects, where draw works several dealt biography Zahra Virgin (p) was research deals with male workbooks that were classified for girlfriend (p) since the second century AH, which is my father Mkhnf, Lot bin Yahya bin Said Azdi (d. 157 AH / 773 AD) the first class

Attention is one of the mental processes of knowledge that play an important role in the life of the individual in general and the child's life, in particular, the child relates to the external environment through its interaction with it, to achieve the adjustment with his environment and harmony with his community.

Much ness and multiplicity of information sources make the child need to scan and exploration to provide the appropriate response by handling sensory stimuli involving the discovery of stimulus and receive it by sensory devices then pay attention to it and realizing and storing it in memory and restoring it in the next positio