The study aimed to explore the relationship between future anxiety and life orientation of male and female nurses, working in government hospitals of Gaza Strip governorates. The study sample consisted of 228 nurses (131 male nurses and97 female nurses. To achieve the study objectives , the researcher used the future anxiety scale, prepared by the researcher, and life orientation scale prepared by Scheier and Craver (1985 ) and translated into Arabic by Bader Al-Ansari . The results indicated that the level of future anxiety among nurses working at government hospitals was (64.85%), a high percentage, whereas life orientation was (65.96%), a low percentage. Additionally , the results showed that the Pearson correlation coefficient between future anxiety and life orientation was (0.455-), which was a negative correlation coefficient, and that the relationship was inverse that is the greater the future anxiety the less is the level of life orientation. Likewise, the findings showed the absence of a statistically significant effect between future anxiety and the interactions between the study variables (sex, educational qualification, experience, and place of residence, the monthly salary). Besides, there was no statistically significant effect between future anxiety and sex, and there was no statistically significant effect between life orientation and bilateral interactions between the (educational qualification, the monthly salary), and there was no statistically significant effect between life orientation and the combined interactions .