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The present study describes employing zero-, 1st - and 2nd -order derivative spectrophotometric methods have been
developed for determination of lorazepam (LORA) and clonazepam (CLON) in commercially available tablets. LORA was
determined by means of 1st (D1), 2nd (D2) derivative spectrophotometric techniques using zero cross, peak height, and Peak
area. D1 used for the determination of CLON by using zero cross and peak height while D2 (zero cross) was used for the
determination of CLON. The method was established to be linear in concentration containing different ratios of LORA and
CLON range of (20-200 mg/L) and (5-35 mg/L) at wavelength range (250 -370 nm), (210-370nm) respectively. The proposed
techniques are highly sensitive, precise a
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