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This research, involved synthesis of some new 1,2,3-triazoline and 1,2,3,4-
tetrazole derivatives from antharanilic acid as starting material .The first step
includes formation of 2-Mercapto-3-phenyl-4(3H)Quinazolinone (0) through reacted
of anthranilic acid with phenylisothiocyanate in ethanol, then compound (0) reaction
with chloro acetyl chloride in dimethyl foramamide (DMF) to prepare intermediate
S-(α-chloroaceto-2-yl)-3-phenylquinazolin-4(3H)-one (1); compound (1) reacted
with sodium azide to yield S-(α-azidoaceto-2-yl)-3-phenylquinazolin-4(3H)-one (2),
while Schiff bases (3-10) were prepared from condensation of substituted primary
aromatic amines with different aromatic aldehydes in absolute ethanol as a solvent.
Compound (2)
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