Background : Breast cancer is the most common cancer of
women. When breast cancer is detected and treated early,
the chances for survival are better. Surgery is the most
important treatment for non-metastatic breast cancer.
Al-Kindy Col Med J 2008 Vol.5(1) 40 Original Article
Objectives : The aim of this study is to review different
clinical presentation and to evaluate types of surgical
procedures and complications in treatment of nonmetastatic breast cancer.
Method : During the period from Jun 1998 to May 2005,
93 patients with non-metastatic breast cancer were
diagnosed and treated surgically in 2 hospitals in Baghdad (
Hammad Shihab military hospital and Al-Kindy teaching
hospital).
Results : Women constituted ( 98.93% ), while men
constituted (1.07%), with male to female ratio of (0.01:1).
The peak incidence of non-metastatic breast cancer (25.8%)
was at age group 51-60 years, while (60.2 % ) of cases
happened in women over 50 years of age. The right breast
was the most common side affected, and the upper outer
quadrant of the breast was the most common location
affected by cancer. Painless lump (91.4%) was the most
common symptom, and the hard lump was the most
common sign (100%).
The highest frequency of cases was diagnosed in stage II
followed by stage III, and invasive ductal cancer was the
most common histopathologic type.
(87.1 %) of patients underwent modified radical
mastectomy, while (12.9%) underwent breast-conservation
surgery. Breast-conservation surgery carried higher
incidence of recurrent disease than modified radical
mastectomy (33.3% vs.13.6%).
Conclusion : The majority of patients with non-metastatic
breast cancer were over 50 years of age, and the
preponderance were diagnosed in stage II. Modified radical
mastectomy may be preferable method for treatment as it
carries a lower rate of local or distant recurrence than
conventional breast-conservation surgery procedures
Fifteen local isolates of Pseudomonas were obtained from several sources such as soil, water and some high-fat foods (Meat, olives, coconuts, etc.). The ability of isolates to produce lipase was measured by the size of clear zone on Tween 20 solid medium and by measuring the enzymatic activity and specific activity. Isolate M3 (as named in this study) was found to be the most efficient for the production of the lipase with enzymatic activity reached 56.6 U/ml and specific activity of 305.94 U/mg. This isolate was identified through genetic analysis of the 16S rRNA gene. and it was shown that the isolate M3 belongs to Pseudomonas aeruginosa with 99% similarity. The DNA of isolate M3 was extracted and lipase gene was amplified through PCR tec
... Show MorePrimary amide derivatives as histone deacetylase inhibitors (HDACIs) are very rare. This paper describes the synthesis of primary amide derivatives (compounds 6 and 7) that have the requirements to be histone deacetylase inhibitors of the zinc-binding type. Both of them exhibited good cytotoxicity against the tested cancer cell lines with much lower cytotoxicity against normal cell line.
Need organizations today to move towards strategic thinking which means analyzing situations faced by particular challenges of change in the external environment, which makes it imperative for The Organization That to reconsider their strategies and orientations and operations, a so-called re-engineering to meet those challenges and pressures, to try to achieve improvement root in the installation of the organization and methodscompletion of its work towards achieving high levels of performance and that is reflected to achieve its objectives, and this is what aims to Current search to deal with implications characteristics of strategic thinking in the stages of application re-engineering business of the company General Industries
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