Background: Fetal macrosomia represent a
continuing challenge in obstetrics and increasing in
it's occurrence as well as it is associated with maternal
and perinatal complications.
Objective : To determine the maternal and perinatal
outcome related to fetal macrosomia.
Design: A prospective case control study.
Patients and methods) :10th March-31st May, 2006
A prospective case control study had done over the
period from 10th March to 31st May, 2006 in Al-Batool
maternity teaching hospital in Mosul city .The study
group consisted from 633 singleton alive newborns
with gestational age ≥37weeks weighing 4000 grams
and heavier and mothers of these newborns compared
with control group which consisted from 4155
singleton alive newborn with gestational age
≥37weeks weighing 2500-3999 grams and mothers of
these newborns .The obstetrical outcome variables
which compared between the two groups include mode
of delivery, indication of caesarean section and
maternal and perinatal complications.
Results :
Macrosomic newborns (≥4000grams) delivered in this
study account for (12.45%) of total deliveries.
Newborns with a birth weight of ≥4500grams
constitute 2.65% from all deliveries .Male Newborns
(65.24%) was higher and statistically differed among
the study group (p value=0.001).
Instrumental vaginal delivery (P value=0.010,Odd
ratio :2.12, 95 %CI :1.19-3.76) and cesarean section
delivery (P value=0.000,Odd ratio:1.63, 95 %CI :
1.34-1.98), mainly the emergency cesarean section
(18.79%), were significantly different among the
study group .Failure of progress of labour and
cephalopelvic disproportion were the main indications
in study group and showed statistical significant
difference between the two groups.
Among the study group, there was neither maternal
death nor uterine rupture but there was higher
occurrence of postpartum hemorrhage, genital tract
trauma and shoulder dystocia which were significantly
different when it compared with control group .Erb's
palsy was the main perinatal complication and was
statistically different among macrosomic group (P
value=0.000) .
Conclusion: Fetal macrosomia was associated with
higher rate of instrumental vaginal delivery and
caesarean section mainly due to failure of progress of
labour and cephalopelvic disproportion .There were
higher rate of postpartum haemorrhage, genital tract
trauma as well as shoulder dystocia with neither
maternal death nor uterine rupture in study group .
Among macrosomic newborn, Erb's pulsy was the
main perinatal complication
Abstract Background: Acute myeloid leukemia (AML) results from sequential genetic alterations in a normal hematopoietic stem cell or its progenitors giving rise to an autonomous clone that dominates the bone marrow leading to marrow failure. MicroRNAs are short non-coding nucleic acid sequences that regulate post-transcriptional gene expression by base-pairing with their target mRNAs. MiRNAs can be secreted into extracellular fluids and carried to target cells by vesicles or bound to proteins. Intracellular and circulating miRNAs are believed to be useful markers in the diagnosis, prognosis, and treatment of various cancers. Practically, circulating miRNAs are more stable at room temperatures and extreme conditions. Purpose: This study aim
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The prostaglandins inside inflamed tissues are produced by cyclooxygenase-2 (COX-2), making it an important target for improving anti-inflammatory medications over a long period. Adverse effects have been related to the traditional usage of non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment of inflammation, mainly centered around gastrointestinal (GI) complications. The current research involves the creation of a virtual library of innovative molecules showing similar drug properties via a structure-based drug design. A library that includes five novel derivatives of Diclofenac was designed. Subsequently, molecular docking through the Glide module and determining the binding free energy implementing the P
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Background This study aimed to evaluate the efficacy of once-daily liraglutide as an add-on to oral antidiabetics (OADs) on glycemic control and body weight in obese patients with inadequately controlled type 2 diabetes (T2D). Methods A total of 27 obese T2D patients who received 7 months (0.6 mg/day for the first month, 1.2 mg/day for 3 months, and 1.8 mg/day for 3 months) of liraglutide treatment as an add-on to OADs were included. Data on body weight (kg), fasting plasma glucose (FPG, mg/dL), postprandial glucose (PPG, mg/dL), and HbA1c (%), were recorded. Results Liraglutide doses of 1.2 mg/day and 1.8 mg/day were associated with significant decreases in body weight (by 8.0% and 11.9%, respectively, p < 0.01 for each) and HbA1c (by 20.0
... Show MoreThe research tackles the potential challenged faced the translator when dealing with the literal translation of nowadays political terms in media. Despite the universal complexity of translating political jargon, adopting literal translation introduces an added layer of intricacy. The primary aim of literal translation is to maintain faithfulness to the original text, irrespective of whether it is in English or Arabic. However, this method presents several challenges within the linguistic and cultural dimensions. Drawing upon scholarly sources, this article expounds upon the multifaceted issues that emerge from the verbatim translation of political terms from English into Arabic. These problems include political culture, language differenc
... Show MoreThe development of new cephalosporins with improved activity against resistant microbes, such as, MRSA (methicillin resistant Staph. aureus), P. aeruginosa, is of high potential. Chemical synthesis of two new series of thiadiazole linked to cysteine (series 1) and cephalosporins containing thiadiazole linked to cysteine through disulfide bond (series 2) were achieved. The chemical structures of the synthesized compounds were confirmed using spectral (FT-IR, 1H-NMR) and elemental microanalysis. The incorporation of privileged chemical moieties, such as, thiadiazole, Schiff base, cysteine and sulfonamide, has been found to have great contribution to the antimicrobial activities. Compounds of series 1 (1
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