Background: Thyroid surgery is most common endocrine surgery in general surgical practice. Objectives: the aim of this work is to evaluate the feasibility, benefits and outcomes of open mini-incision thyroidectomy and compared the results with that of conventional thyroidectomy. The comparison between the two groups was in term of incision length, amount of blood loss, time of operation, postoperative pain, hospital stay and the cosmetic outcomes.Type of the study: this is a single-blinded randomized controlled studyMethods: This study compared the advantages and outcomes of 22 patients subjected to mini-incision thyroidectomy (Group A) with the equal numbers of patients subjected to conventional thyroidectomy (Group B).Results: the operative time was statistically longer in minithyroidectomy than with conventional thyroidectomy. Postoperative pain score in the operative day and 24 hours postoperatively showed a significant difference in favor of mini-incision thyroidectomy. The cosmetic outcome and patients satisfaction was significantly and far better in minithyroidectomy group. The results between both groups were comparable regarding the postoperative complications. The hospital stay was shorter in the mini-incision group than in conventional group but the difference was not significant.Conclusions: mini-incision thyroidectomy is simple, safe and practical procedure that achieves the same results and the rate complications to the conventional thyroidectomy with less post operative pain and better aesthetic results. It is easily converted to conventional technique when necessary without added risks .