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The present study aims to evaluate the effects of methotrexate (MTX) with and without vitamin A (Vit. A)
on some biochemical parameters and histological structure in male rabbits liver. Twenty male rabbits
weighing 1250-1480 gm were divided into four equal number groups. The first group was given 2 ml
distilled water as control group. The second group was given MTX (20 mg/kg), the third group was given
Vit. A (5000 IU), while the fourth group was given MTX (20 mg/kg) +Vit. A (5000 IU) in alternative days.
Following four weeks of treatment, lipid profile total cholesterol (TC), triglycerides (TG), high-density
lipoprotein (HDL), [low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL)]; in addition
to thyroid hormones tr
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