Endometriosis, an autoimmune disease is among one of the most challenging of the 21 st century that affects women in reproductive age. The aim of the present study is to highlight the role of IL-36γ, and its relationship with other cytokines (Ang-2 and TNF-α) in the pathogenesis of endometriosis . Seventy five (75) consecutive women patient of reproductive age (25-40) years were enrolled in this study , Patients were divided into three groups , group 1 (G1) included (25) newly diagnosed endometriotic patients , that were not given any treatment related to Gynecology or anti-inflammatory medications . Second group : group 2 (G2) consists of (25) endometriotic patient who were treated with zoladex for 3 to 5 months , they received zoladex injection every 28 day in the first day after diagnosis. The third group: Group 3 (G3) involved (25) patients with recurrent endometriosis , they were post treatment of zoladex and diagnosis revealed recurrence of endometriosis. Patients groups were compared with two control groups , with matched age with patients’ groups. The first control group (C) included (25) healthy women , and the second control group or pathological control group (PC) involved (25) women suffering from infertility caused by gynecological disorder unrelated to endometriosis.IL-36γ , Ang-2 and TNF-α were estimated in sera of studied groups. The results from this study revealed that IL-36γ levels were highly significant increase (p<0.001) and significant increase (p<0.05) in G1 comparing with groups C and PC respectively. While high significant decrease(p<0.001) was found in G2 comparing with G1. Also , there are no significant differences (p≥0.05) shown in G2 comparing with C group and in G3 comparing with G1.On the otherhand , Ang-2 levels were highly significant increased (p<0.001) and significant increase (p<0.05) in G1 comparing with groups C and PC respectively. While significant decrease (p<0.05) was found in G2 comparing with G1. Also , there are no significant differences (p≥0.05) in Ang-2 levels shown in G2 comparing with C group and in G3 comparing with G1 Our results also implied that TNF-α levels were highly significant increased (p<0.001) in G1 comparing with C group. While no significant differences (p≥0.05) was found in G1 comparing with PC group and in G3 comparing with G1. Also there are significant differences (p<0.05) shown in G2 comparing with G1 and C group. Our findings for endometriotic patient groups. A high significant difference was found between Ang-2 and TNF-α levels with IL-36γ for G1 , G2 and G3. The conclusion of this study reveals that IL-36γ could be considered a novel biochemical marker in endometriotic patients. Conclusion could be drawn from the results that endometriosis may be influenced on the cytokines secretion such as IL-36γ beside Ang-2 and TNF-α in G1 and G3 , suggesting that inflammatory / immunological factors associating with angiogenesis responses play crucial roles in the pathogenesis of endometriosis. Also, the results showed the role of zoladex in alteration immune responses as shown in G2
The attribute quality control charts are one of the main useful tools to use in control of quality product in companies. In this paper utilizing the statistical procedures to find the attribute quality control charts for through fuzzified the real data which we got it from Baghdad Soft Drink Company in Iraq, by using triangular membership function to obtain the fuzzy numbers then employing the proposed ranking function to transform to traditional sample. Then, compare between crisp and fuzzy attribute quality control.
This paper addresses the use of adaptive sliding mode control for the servo actuator system with friction. The adaptive sliding mode control has several advantages over traditional sliding mode control method. Firstly, the magnitude of control effort is reduced to the minimal admissible level defined by the conditions for the sliding mode to exist. Secondly, the upper bounds of uncertainties are not required to be known in advance. Therefore, adaptive sliding mode control method can be effectively implemented. The numerical simulation via MATLAB 2014a for servo actuator system with friction is investigated to confirm the effectiveness of the proposed robust adaptive sliding mode control scheme. The results clarify, after
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Diabetic foot ulcer (DFU) or Lower limb ulcers are one of the major complications caused by diabetes mellitus especially when patients fail to maintain tight glycemic control. DFU is linked to multiple risk factors along with the genetic factors and ethnicity which play a significant role in the development of DFUs through their effects on multiple aspects of the pathophysiological process. This narrative review aimed to summarize all the previous studies within the last ten years associating gene polymorphism and DFU. Polymorphism associated with vascular endothelial growth factor (rs699947), the G894T polymorphism of the endothelial nitric oxide synthase gene, interleukin-6–174 G>C gene polymorphism, heat shock protein 70 gene polymorph
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Background: Chronic kidney disease is a gradual loss of kidney function with diabetes and hypertension as the leading cause. Chronic kidney disease is one of these systemic diseases that can affect salivary contents. Aims: This study aimed to assess salivary immunoglobulin A, interleukin-6 and C- reactive protein in chronic kidney disease patients on hemodialysis and those on conservative treatment in comparison with control subjects. Materials and methods: Ninety subjects were included in this study divided into three groups: 30 patients with chronic kidney disease on hemodialysis for at least 6 months ago; 30 patients with chronic kidney disease on conservative treatment and 30 healthy control subjects. Secretory immunoglobulin A, inte
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The ligand 4-(2-aminmo-5-nitro-phenylazo)-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one derived from 4-aminoantipyrine and 4-nitroaniline was synthesized. The synthesized ligand was characterized by 1HNMR, FT-IR, UV-Vis spectra and (C.H.N) analysis. Complexes of (YIII and LaIII ) with the ligand were prepared in aqueous ethanol with a 1:2 M:L ratio and at optimum pH. The prepared complexes were characterized by using flame atomic absorption, FT-IR, UV-Vis spectra,(C.H.N) analysis and conductivity measurement. The stoichiometry of complexes was studied by the mole ratio and job methods. A concentration range (1×10-4 - 3×10-4 M) obeyed Beer's law, the complex solutions show high values of molar absorption. On the basis of physicochemical
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The ligand 4-(2-aminmo-5-nitro-phenylazo)-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one derived from 4-aminoantipyrine and 4-nitroaniline was synthesized. The synthesized ligand was characterized by 1HNMR, FT-IR, UV-Vis spectra and (C.H.N) analysis. Complexes of (YIII and LaIII ) with the ligand were prepared in aqueous ethanol with a 1:2 M:L ratio and at optimum pH. The prepared complexes were characterized by using flame atomic absorption, FT-IR, UV-Vis spectra,(C.H.N) analysis and conductivity measurement. The stoichiometry of complexes was studied by the mole ratio and job methods. A concentration range (1×10-4 - 3×10-4 M) obeyed Beer's law, the complex solutions show high values of molar absorption. On the basis of physicochemical
... Show MoreThis study aims to document and describe the speech sounds and sound inventory that are present in Sorani which is dialect of Kurdish and compare the results with their English counterparts. The research concentrates on the voicing system and the quality of Sorani sounds which are measured by using the voice onset time (VOT) of the stop consonants, and the first three formants of the vowel sounds; the closure duration of voiceless stop consonants in medial position is measured as well.
Ten native speakers of the Sorani dialect (5 males and 5 females) participated in this experiment. All speakers are between 20 and 50 years of age, were born in Sulaimanyiah, migrated to the US, and remain in the US at the time of recording.
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