Interleukin-35 (IL-35) is a novel anti-inflammatory of IL-12 family member cytokine. High sensitive C- reactive protein (hs-CRP) is a marker of inflammation disease. This study was obtained to estimate the concentrations of IL-35 and hs-CRP in cardiovascular diseases Iraqi patients. The study contained 79 subjects divided into two groups, 47 (21 male and 26 female) suffering from cardiovascular diseases and 32 as control group. The concentration of IL-35 and hs-CRP was measured by enzyme- linked immune sorbent assay (ELISA). The results revealed that the concentrations of IL-35 and hs-CRP are increased in patients group. IL-35 is strongly expressed in human advanced plaque and hs-CRP. Therefore these two biomarkers could be useful as addition in diagnosis of cardiovascular diseases. A significant increase of IL-35 and hs-CRP levels in patients group compared with controls (P<0.005) and there was a positive correlation between IL-35 with hs-CRP in patients group. The results of this study revealed that IL-35 is a potentially anti-inflammatory marker in cardiovascular diseases.
In this study, Iraqi bentonite taken from Trefawi area/ Al-Anbar region province/ Iraq, was activated to enhance its rheological and filtration properties and increase its quality by decreasing the non-clay minerals (impurities), in order to be used in Iraqi oil companies instead of commercial bentonite. Bentonite was characterized by X-ray diffraction (XRD), X-ray fluorescence (XRF) and particle size distribution (PSD) before and after activation to show the effects on its mineral and chemical properties. The rheological properties of bentonite were enhanced by using different weights (0.4, 0.5, 0.6, 0.7 and 0.8 gm) of sodium carbonate (Na₂CO₃), whereas the filtration properties were enhanced by using different weights (0.5
... Show MoreThis study aims to assess some seroprevalence of toxoplasmosis in chronic renal failure (CRF) patients undergoing hemodialysis in dialysis centers in some Baghdad hospitals, by testing the blood samples with enzyme linked Immunosorbant assay (ELISA) IgG and IgM, to determine the incidence of toxoplasmosis in hemodialysis patients. Hemodialysis patients infected with Toxoplasma. gondii were appeared with 129(32.25%) seropositive anti-Toxoplasma IgG. The age groups (43-51) year and (52-60) years of hemodialysis patients showed the highest percentage of anti-Toxoplasma gondii antibodies. An increase of the seropositivity rate was detected with increasing length of time on hemodialysis treatment. Females had the highest significant percentag
... Show MoreThe purpose of this study was to develop poloxamer-based in-situ gel of chloramphenicol aiming to increase bioavailability and prolong corneal contact time, controlling drug release, and enhancing ocular bioavailability. The in-situ gel was prepared using different concentrations of poloxamer 407 combined with hydroxypropyl methyl cellulose (HPMC) or carbapol 940 to achieve gelation temperature about physiological temperature and improve rheological behavior and gelling properties of poloxamer gel. The prepared formulations were evaluated for their appearance, pH, and sol-gel transition temperature. The formulations F2, F3, and F5 have a gelation temperature within the accepted range 35-370C an
... Show MoreSilymarin (SM) is a plant extract obtained from Silybum marianum( milk thistle) . It is class II type drug according to Biopharmaceutics Classification System with low bioavailability due to its low solubility.
Micro/nanonization during crystallization, surface modification and crystal structure modification may improve the dissolution rate of poorly water-soluble drugs.
The aim of this study was to increase the water solubility and dissolution rate of SM by in-situ micronization using solvent change either by stirring or ultrasonic method. Stabilizers like Gelatin, PVP-K30, HPMC15, Pulullan were used to stabilize the prepared ultrafine crystals. Effect of type and concentration of hydrophilic polymer, solv
... Show MoreThe current research aims to verify the relationship and impact of internal control activities as an independent variable in its dimensions (efficiency, training, independence) in making administrative decisions as a responsive variable and its dimensions (identifying and diagnosing the problem, searching for alternatives, evaluating alternatives, choosing the appropriate alternative, implementing the decision, following up Decision and evaluation) in the Kirkuk Water Directorate, as well as to identify the levels of their practices, and then try to come up with a number of recommendations contribute to the strengthening of internal control activities and the process of making administrative decisions of the researched Directorat
... Show MoreBioavailability is the objective for an optimum formulation. The target of the analysis is to maximize both the fluidity and disintegration profile of class II weakly compounds that are water-soluble. Anti-dyslipidemia drug rosuvastatin calcium (RC) (bioavailability 20%) through formulating as nanofibers (NFs) using electrospinning (ES) technology. Twenty formulas were prepared, and different polymers and polymer combinations with various concentrations were used such as polyethylene oxide (PEO) polyvinyl pyrrolidine (PVPK-30), and hydroxypropyl methylcellulose (HPMC). Three distinct groups of maximum parameters, including polymeric solution, electrospinning method, and ambient parameter, are capable of influencing the creation alon
... Show MoreTechnically, mobile P2P network system architecture can consider as a distributed architecture system (like a community), where the nodes or users can share all or some of their own software and hardware resources such as (applications store, processing time, storage, network bandwidth) with the other nodes (users) through Internet, and these resources can be accessible directly by the nodes in that system without the need of a central coordination node. The main structure of our proposed network architecture is that all the nodes are symmetric in their functions. In this work, the security issues of mobile P2P network system architecture such as (web threats, attacks and encryption) will be discussed deeply and then we prop
... Show MoreThe Mishrif Formation is one of the most important formation in oil fields, which is located in southern part of Iraq, and it is of Upper Cretaceous age. Tuba field is located nearly 40 km SW – Basrah city. It is bounded from east by Zubair oil field (5 km distance) and from west by Rumaila (2 km distance). The Tuba oil field is situated between Zubair oil field in the east and Rumaila in the west, and is separated by two depressions.
The rock (core and chips) samples have been collected systematically from cores of Mishrif Formation that are available from stores of southern oil company to prepare thin sections and slides—these slides have been examined by using microscope. These samples have been taken from all parts of the rese
Background: Bilastine is a non-sedating, second-generation antihistamine used to treat urticaria and allergic conjunctivitis. Objective: to formulate and test bilastine as a mucoadhesive ophthalmic in situ gel in order to extend its presence at site for longer time and help treat conjunctivitis and allergic rhinitis. Methods: We prepared formulations using different concentrations of poloxamers (Poloxamer 407 (P407) and Poloxamer 188 (P188)) in combination with hydroxypropyl methyl cellulose (HPMC). The prepared formulas were evaluated for their physicochemical properties, sol-gel transition temperature, viscosity, mucoadhesive strength, drug release, and kinetic modeling. Results: The prepared in situ gels were clear and transparen
... Show MoreDarifenacin hydrobromide (DH) is the more recent uroselective M3 receptor antagonist for treating uncomplicated overactive bladder (OAB). This study was aimed to formulate DH as fast dissolving buccal films (FDBFs) using a solvent casting method to enhance patient’s compliance.
Films were prepared by using polyvinyl alcohol (PVA) as a film forming polymer. Different types and concentrations of superdisintegrants (croscarmellose sodium, sodium starch glycolate, indion 414) were used to select the best formula by studying the physicochemical properties of the films, disintegration time (DT) and percent drug release.
&nb
... Show More