Spectrophotometric Determination of Mefenamic Acid in Pharmaceutical Preparations

Sarmad B . Dikran; Moen I. Al-Joboury; Alaa K. Mohammed; Ahmed S. Naser

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Publication Date

Wed Apr 12 2017

Journal Name

Ibn Al-haitham Journal For Pure And Applied Sciences

Volume

27

Issue Number

3

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Spectrophotometric Determination of Mefenamic Acid in Pharmaceutical Preparations

Spectrophotometric

Mefenamic acid

1

2-Nphatha quinona-4-Sulfonic sodium

Sarmad B . Dikran

Moen I. Al-Joboury

Alaa K. Mohammed

Ahmed S. Naser

...Show More Authors

A simple, accurate and precise spectrophotometric method has been proposed for the determination of Mefenamic acid(MA) in dosage forms. Proposed method based on the reaction of cited drug with 1,2-Naphthoquinone-4-Sulfonic sodium (NQS). The optimum experimental condition have been studied. Beer's Law is obeyed in the concentration range 0.5-10.0 Âµg/mL at 450nm with detection limit of 0.189Âµg/mL. Effect of pH, reaction time, and volume of NQS on the determination of Mefenamic acid, have been examined. The proposed method has been successfully applied for the determination of Mefenamic acid in pharmaceutical preparations.

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Publication Date

Wed Feb 28 2018

Journal Name

International Journal Of Science And Research (ijsr)

Synthesis, Structure Determination and Biological Study of Some Complexes of New Ligand Derived from L-ascorbic Acid

X-ray diffraction

L-ascorbic acid

TGA

bidentate

trichloroacetic acid

metal complexes

Salah Mohammed Fezea

...Show More Authors

2,2'-(1-(3,4-bis(carboxydichloromethoxy)-5-oxo-2,5-dihydrofuran-2-yl)ethane-1,2-diyl)bis(oxy)bis(2,2-dichloroacetic acid) a derivative of L-ascorbic acid was prepared by reaction of L-ascorbic acid with trichloroacetic acid (1:4) ratio, in the presence of potassium hydroxide. A series of new metal complexes of this ligand were prepared by a reaction with the chlorides of Cd(II), Co(II), Ni(II), Cu(II) and Zn(II). The new ligand and its complexes were identified by C.H.N., IR, UV-visible spectra, Thermogravimetric analysis (TGA), as well as 1H, 13C-NMR and Mass spectra for ligand L. The complexes were also identified by molar conductance, atomic absorption, magnetic susceptibility and X-ray diffraction for Cu (II) complex. FT-IR spectra

Publication Date

Fri Apr 01 2022

Journal Name

Baghdad Science Journal

Iron (II) Determination in Lipstick Samples using Spectrophotometric and Microfluidic Paper-based Analytical Device (µPADs) Platform via Complexation Reaction with Iron Chelator 1, 10-phenanthroline: A Comparative Study

Colorimetric

Cosmetic

Heavy metals

Iron (II)

µPADs platform

Spectrophotometric.

Ekhlas A.

Jwan O.

Ban O.

...Show More Authors

This study was undertaken to introduce a fast, accurate, selective, simple and environment-friendly colorimetric method to determine iron (II) concentration in different lipstick brands imported or manufactured locally in Baghdad, Iraq. The samples were collected from 500-Iraqi dinars stores to establish routine tests using the spectrophotometric method and compared with a new microfluidic paper-based analytical device (µPAD) platform as an alternative to cost-effective conventional instrumentation such as Atomic Absorption Spectroscopy (AAS). This method depends on the reaction between iron (II) with iron(II) selective chelator 1, 10-phenanthroline(phen) in the presence of reducing agent hydroxylamine (HOA) and sodium acetate (NaOAc) b

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Publication Date

Mon Apr 20 2020

Journal Name

Ibn Al-haitham Journal For Pure And Applied Sciences

Spectrophotometric Method for the Estimation of Ceftriaxone in Pure Form and Pharmaceuticals

Ceftriaxone

Azo dye

Coupling

Spectrophotometric

2

5-dimethylphenol

4-tertbutylphenol

Aya W.

Salam A.H.

...Show More Authors

Ceftriaxone sodium were one of the widely antibacterial drugs used. Azo dye derivatization of diazonium salt that formed via the reaction between ceftriaxone with hydrochloric acid and sodium nitrite was developed for the on-research drug analysis then coupling with each one 2,5-dimethylphenol (2,5-DMP) and 4-tertbutylphenol (4-TBP) respectively in the alkaline media. The developed diazonium coupling methods include an optimization study. The results show a limit of detection and limit of quantification 0.482, 0.284 Âµg/mL, and 1.607, 0.945 Âµg/mL using 2,5-DMP and 4-TBP reagents respectively. Moreover, the recovery % obtained was 100.89%, and 103.37% at linear concentration range 3.0 â€“ 50, and 10 â€“ 30 Âµg/mL, with mo

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(2)

Publication Date

Sun Sep 06 2009

Journal Name

Baghdad Science Journal

Spectrophotometric Study of ?-Irradiated PM-355

"PM-355

Spectrophotometric study-irradiated PM-355

High doses dosimeters"

Nahida J.H.

Nada F.

Mohammed T. Abdul

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The aim of the present work is concerned with the effect of ?-irradiation on PM-355 with absorbed dose of (30-160Mrad) range. This polymer is evaluated spectrophotometrically for use as high dose dosimeters. The absorption spectra of irradiated samples showed radiation induced absorption changes. There is an increment in absorption proportional with absorbed dose. This increment is attributed to interfaces traps which, are formed by irradiation. Calibration curve was drawn .The linear relation was found in calibration curve, and dosimeter range was determined from the linear part. The linearity in response curve suggested that PM-355 could be used as dosimeter within (30-160Mrad) rang. Energy gap shift was used as a second tool to determin

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Publication Date

Mon Dec 30 2002

Journal Name

Iraqi Journal Of Chemical And Petroleum Engineering

Aerobic Filter Treatment of Pharmaceutical Waste

Nahidh W

Hammodi A

Kassim H

Abbas H

...Show More Authors

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Publication Date

Mon Feb 14 2022

Journal Name

Proceedings Of The National Academy Of Sciences

Pharmaceutical pollution of the world’s rivers

John L.

Alistair B.A.

Dana W.

Kenneth M. Y.

Racliffe W. S.

Cristóbal

Aiko D.

Julie

Marc

Robert A.

Alejandra

Aida

Anja

Pedro

Macarena

Chris

Magdalena

Monique

Thais

Vahagn

Yekaterina

Clare S.

Christopher J.

Thilo

Tapos

Volga

Jessica

Jean L.

Francisco

Maria T. P.

Victorien

Gildas

Oumar

Jules M.

Linda E.

Michelle

Donald

Romaric

Jaime

Guang-Guo

Chang-Er

Martha

Jina

Jean-Paul

John

Suspense A.

Penelope

Silvia

Nikolina

Milena

Despo

Lida

Vladimíra

Jan

María

Bayable A.

Jeanne

Arnaud

Peter

Ilia

Sven

Gerasimos

Halldór P.

Molly

Thatikonda

Manisha

Anindrya

Adee

Nima

Ali

Omar

Salem S.

Francesco

Benny

Tom

Koffi Marcellin

Bakhyt

Raikhan

Lydia

Jemimah K.

Peter

Victor

Nathaniel T.

Sheck

Ahmad Zaharin

Ley Juen

Mahamoudane

Seydou T.

Rik

Olatayo

Muhammad

Ziad

Aaron

Jorge Manuel

María

Heidi

Ian

Fabio

Alhaji Brima

Bashiru M.

Vesna

Mitja

Melusi

Kyungho

Habyeong

John L. Celestino

Andreu

Priyanie

Anna

Gisela

Armin K.

Alex C.

Jheng-Jie

Rebecca

Madaka

Ulas

Turgut T.

Julius B.

Yuliya

Yuriy

Horacio

Andrés

Douglas B.

Maritza

David

Charles

...Show More Authors

Environmental exposure to active pharmaceutical ingredients (APIs) can have negative effects on the health of ecosystems and humans. While numerous studies have monitored APIs in rivers, these employ different analytical methods, measure different APIs, and have ignored many of the countries of the world. This makes it difficult to quantify the scale of the problem from a global perspective. Furthermore, comparison of the existing data, generated for different studies/regions/continents, is challenging due to the vast differences between the analytical methodologies employed. Here, we present a global-scale study of API pollution in 258 of the world’s rivers, representing the environmental influence of 471.4 million people across

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Publication Date

Tue Sep 01 2020

Journal Name

Al-nahrain Journal Of Science

Spectrophotometric Determination of Co(II) in Vitamin B12 Using2-(biphenyl-4-yl)-3-((2-(2,4-dinitrophenyl) hydrazono)methyl) imidazo [1,2-a]pyridine as Ligand by Flow Injection–Merging Zone Analysis

Suhair

Bushra

Naeemah

...Show More Authors

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(2)

Publication Date

Wed May 24 2017

Journal Name

Ibn Al-haitham Journal For Pure And Applied Sciences

Elevated Levels of Sialic Acid and Lipid-Associated Sialic Acid in Plasma of Rheumatoid Arthritis Patients

Sialic acid

Lipid- associated Sialic acid.

N. S.

...Show More Authors

The objective of this study is to evaluate plasma levels of total Sialic acid TSA and Lipid â€“associated Sialic acid LSA as a marker of Rheumatoid Arthritis AR. Plasma Sialic acid is known as a parameter of inflammation. In the present study, in order to explore the potential role of sialic acid in arthritis rheumatoid, plasma sialic acid levels, plasma LSA and total protein in patients with arthritis rheumatoid were measured. A total 40 patients were compared with 40 healthy control subjects. Plasma TSA, LSA and TP level were determined spectrophotometrically in plasma samples. Plasma Sialic acid levels were significantly increased in RA (88.48Â±14.15 mg/dl, P<0.05) and LSA level were significantly increased in RA (26.3

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Publication Date

Mon Jan 01 2024

Journal Name

Baghdad Science Journal

A New Approach for Developing Spectrophotometric Determination of Phenylephrine Drug in Pure, Pharmaceutics and Serum Samples Using Sodium Periodate as Oxidizing Agent via a Green Method of CFIA/Merging Zone Technique

CFIA/MZ technique

DNPH

Pharmaceutics

Phenylephrine. HCl

Serum samples

Shahad L.

Bushra B.

...Show More Authors

The research involved a rapid, automated and highly accurate developed CFIA/MZ technique for estimation of phenylephrine hydrochloride (PHE) in pure, dosage forms and biological sample. This method is based on oxidative coupling reaction of 2,4-dinitrophenylhydrazine (DNPH) with PHE in existence of sodium periodate as oxidizing agent in alkaline medium to form a red colored product at ʎ_max)520 nm (. A flow rate of 4.3 mL.min^-1 using distilled water as a carrier, the method of FIA proved to be as a sensitive and economic analytical tool for estimation of PHE.

Within the concentration range of 5-300 μg.mL^-1, a calibration curve was rectilinear, where the detection limit was 3.252 μg.mL

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Publication Date

Thu Apr 04 2024

Journal Name

Chemchemtech

ANALYTICAL TECHNIQUES IN PHARMACEUTICAL POLLUTION OF THE WORLD’S RIVERS; A REVIEW

analytical techniques

pharmaceutical pollution

rivers

Jasim M.S.

...Show More Authors

Recent reports of new pollution issues brought on by the presence of medications in the aquatic environment have sparked a great deal of interest in studies aiming at analyzing and mitigating the associated environmental risks, as well as the extent of this contamination. The main sources of pharmaceutical contaminants in natural lakes and rivers include clinic sewage, pharmaceutical production wastewater, and sewage from residences that have been contaminated by drug users' excretions. In evaluating the health of rivers, pharmaceutical pollutants have been identified as one of the emerging pollutants. The previous studies showed that the contaminants in pharmaceuticals that are widely used are non-steroidal anti-inflammatory drugs, ant

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