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ABSTRACT : The restoration of bone continuity and bone union are complex processes and their success is determined by the
effectiveness of osteosynthesis. The use of plants for healing purposes predates human history and forms the source of current
modern medicine. This research was planned to study the histological and immunohisto-chemistry of osteocalcin to evaluate of
effect of local application of lepidium sativum oilon healing of induced bone defect in rat tibia. In this study, fourty albino male
rats, weighting (300-400) gram, aged (6-8) months, will be used under control conditions of temperature, drinking and food
consumption. The animals will subject for a surgical operation of medial side of tibiae bone, in control group the bone
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