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A New Biological System For Detecting Environmetal Carcinogens And /Or Mutagenes And Their Adversary
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A  new  test  system  for  detecting  environment  carcinogenes and/or  mutagenes  and  their  adversary  It  has  been  induced.  One hundred and fifty   mutants   were isolated from   the basidiomycete fungus Coprinus cinereus   which were   resistant to guanine analogue S- az.aguanine .All the spontaneous and induced with UV light origin mutants were isolated from the wild type strains Bc9/6.6 and  Hd5.5

.These mutants were te ted on selective medium containing  different

concentrations of the analogue and also to their ability to usc purine bases and their degredated  products as  a sole  nitrogene source were tested ; and their ability to grow on HAT   medium was tested . According  to  the results obtained  from these test;  mutants  were

classified into four phenotypic groups for each  iJd -type strain .

All  the  8-az.aguanine  resistant  mutants  were  d.ikaryotized   with

compatible wild strains. The dikaryons produced were unable to grow on  medium           containing        8-az.aguanine                     which               establish the recessiveness of the mutations to their respective wi ld-type alleles. Complementation   test  detcrmind  four  genes   which  controll   the resi stance  to 8- azaguaninc in Coprinus cincres   .These genes were desi gnated  azg-1, azg-2, azg'-3, azg-4.Three of these genes azg-1, azg-2 and azg'-4werc carried by Bc9/6.6 and Hl /5.5 mutants. While, azg-3 gene  was found in Bc9/6.6 mutants only.

These  genes  are determ.ind for  the  first  time  in  fungus coprinus cinereus  .

Mutants which carry azg-1  gene were characterized by their inability to use   hypozanthine and                                              guanine as a sole nitrogen source in the

medium ; their failure to grow  on HAT medium  and their resistance

to all concentrations of 8- az.aguanine used.This gene is considered to

 

 

 

 

IBN AL- HAITHAM J.FOH PURE & API'L.SCI.         VOL.19(4) 2006

 

represent  a mutation led to   lose or   modify the specificity of the enzyme hypoxauthine -guanine phosphoribosyl transferase (HGPRT) whi ch play an important role in transferring hypoxauthine and guanine to their nucleotides  by salvage pathway.

Spore analysis indi cated that azg'-1  gene locted in linkage group II

,since it gave a distance of 28 map units with the mating type gene

B.

The assessment of the cytotoxic , mutagn ic and antimutagc•tic role of

the  aqueous extract of  garl ic     (Allium  sativum  L.)  against the genotoxic effect of mitomycin - C

( MMC ) evaluate the ability of the mutagen to induce mutation in

HGPRT gene by    using the asexual spores (oidia )of Copninus cineraus for the strain AZG78 and by depending on the viabil ity and mutation rate in HGPRT gene test .To assess cytotoxity and mutagenecity of garlic extract , gradual concentrations were prepared . The concentration of choice was considered with respect to  two factors ; high survi val rate and low mutagenic  activity (similar to negative control ). To examine the antimutagenic  effects of  the extract, an interation was made between the crude  extract and the mutagen   MMC with respect to three kinds of treatments before , aOer and with mutagen . The study concentrated on two sides 1- on the toxic and /or m utagenic effect of the aqueous extract of garlic . 2 - Antimutagenic activity of the extract with respect to   the mutageen MMC . However,   this activity was dependent on the type of the treatment . The extract showed best antimutagenic activity when it was used before the mutagen , so itis considered as desmutagen to the genotox i c effects of MMC.

These data support the hypothesis that garlic compounds may be eflicacius in preventions of cancer and also we could use the HGPRT

gene as  a  sensitive biological  system  in  detecting environmental mutagenes or carcinogens and their adversary .

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Publication Date
Mon Dec 18 2017
Journal Name
Al-khwarizmi Engineering Journal
High Order Sliding Mode Observer-Based Output Feedback Controller Design For Electro-Hydraulic System
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A perturbed linear system with property of strong observability ensures that there is a sliding mode observer to estimate the unknown form inputs together with states estimation. In the case of the electro-hydraulic system with piston position measured output, the above property is not met. In this paper, the output and its derivatives estimation were used to build a dynamic structure that satisfy the condition of strongly observable. A high order sliding mode observer (HOSMO) was used to estimate both the resulting unknown perturbation term and the output derivatives. Thereafter with one signal from the whole system (piton position), the piston position make tracking to desire one with a simple linear output feedback controller after ca

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Publication Date
Sat Jun 30 2012
Journal Name
Iraqi Journal Of Chemical And Petroleum Engineering
Effect of Annealing on the Crystallization of Poly Vinyl Chloride for Drug Delivery System
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Poly vinyl alcohol has been studied for its ability to form crystallites by using annealing method. Semicrystalline films of poly vinyl alcohol (PVA) were prepared by casting 11.5 wt. % and 13 wt. % PVA aqueous solution onto glass slides at annealing temperature range 90 -120°C and duration time 15- 60 minute. This allowed the macromolecules to form crystallites, small regions of folded and compacted chains separated by amorphous regions where single PVA chain may pass through several of these crystallites. Degree of crystallinity of PVA films (hydrogels) was determined by method of density; on the other hand the swelling behavior was conducted by the determination of water uptake, wet degree of crystallinity, gel fraction and solubilit

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Publication Date
Sun Jun 07 2015
Journal Name
Baghdad Science Journal
The effect of changing the evacuated tube tilt angle and the fluid of the solar collector on the performance of a hybrid solar air conditioning system
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In the hybrid coolingsolar systems , a solar collectoris used to convertsolar energy intoheat sourcein order to super heat therefrigerant leave thecompressor,andthisprocess helpsin the transformation ofrefrigerant state from gaseous statetothe liquid statein upper two-thirdsof thecondenserinstead of the lower two-thirdssuchas in thetraditional air-conditioning systems and this willreduce theenergyneeded torun the process ofcooling.In this research two hybrid air-conditioning system with an evacuated tube solar collector were used, therefrigerant was R22 and the capacity was 2 tons each.The tilt angle of the evacuated tube solar collector was changed and the solar collector fluid was replaced into oil instead of water.A comparison wasi

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Publication Date
Sat Sep 23 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Synthesis and Characterization of New ligand ' ((2-{1..,[(2-hyd_roxy;..benzyli_dene)-hydrazono]- ethyl} benzen_e-l, 3, s--moll and ItComplexes W·itll. (Mn.(11 Fe(n), Cd<11J, a-nd Hg(n).) Tons
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In :the   _pr  sent  _paper we report ths. ynthesis       ·of a new li:ga!!d..

[f4LJ      [{'2 {1-'[(2-hyd•:0xy-.ben:zy1i.den·e)..,bxcJrazanci}:etby-l }benzerie­

J,5 t;rtiol .aad its complexes Â·w-ith '('Mlif(1 J       Fev 1 ),  ed(J'l), and. :f.::I:g 01>-)

The ligand  \VS preP..ated rin tWo steps' • fp I t}Je nrst stea -soJutiQil Qf

-saUcyla[deeyeq.    ip       methatt:oJ .     re3ctcd    lU1der      reflux   

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Publication Date
Wed Aug 19 2020
Journal Name
Revista De Chimie
Synthesis, Characterization and Biological Evaluation of Cr(III), Fe(III), Co(II), Ni(II), Zn(II) and Cd(II) Complexes Using an Azo Dye as Ligand
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Azo ligand 11-(4-methoxyphenyl azo)-6-oxo-5,6-dihydro-benzo[4,5] imidazo[1,2-c] quinazoline-9-carboixylic acid was derived from 4-methoxyaniline and 6-oxo-5,6-dihydro-benzo[4,5]imidazo[1,2-c]quinazoline-9-carboxylic acid. The presence of azo dye was identified by elemental analysis and spectroscopic methods (FT-IR and UV-Vis). The compounds formed have been identified by using atomic absorption in flame, FT.IR, UV-Vis spectrometry magnetic susceptibility and conductivity. In order to evaluate the antibacterial efficiency of ligand and its complexes used in this study three species of bacteria were also examined. Ligand and its complexes showed good bacterial efficiencies. From the obtained data, an octahedral geometry was proposed for all p

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Publication Date
Thu Sep 01 2011
Journal Name
Journal Of Economics And Administrative Sciences
The relationship between organizational justice and empowerment and their impact on achieving organizational commitment (field study in the Department of Labor and Vocational Training)
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The research has deal with the relationship between organizational justice and empowerment and their impact on the achievement of organizational commitment in the office of Labour and Vocational Training. To study the research problem which is represented a sense that employees with low levels of organizational justice and empowerment and the reflection on the organizational commitment of the employees, so that Has been collecting data and information relating to research by designing a questionnaire, were distributed to a sample of (50) people in the office mentioned, and the results of the study to confirm the research hypotheses. and the key results of the research was the presence of correlation relationships and the effect o

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Publication Date
Fri Nov 01 2019
Journal Name
Ecology, Environment And Conservation
Measurement of the concentration of lead in gasoline stations and in air battery factories and their effect of cytogenetic and hematological parameter in workers
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Publication Date
Mon May 08 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
The Effect of Variety , Gibberellic Acid And NPK Fertilizer and their Interactions On Absorption and Transport Rates of Some Macronutrient Elements in Chamomile plant
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This experiment was carried out in the field of botanical garden which belongs to Biologi
Department , College of Education (Ibn Al-Haitham), University of Baghdad during the
growing season 2009-2010.The experiment was designed to study the effect 5 concentrations
of Gibberellic acid(GA3)( 25,50,75,100and125mg.L
-1
) and 2 levels of NPK (17:17:17)
fertilizer (200 and 400 Kg.ha
-1
) and their interaction on the rates of absorption and transport
of some macronutrient elements in two varieties of chamomile plant ( Local variety ,
Matricaria chamomilla L. and German variety , Matricaria recutitia L.) . Randomized
Complete Block Design (RCBD) was used with 3 replicates for each treatment .Control plants

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Publication Date
Mon Apr 01 2024
Journal Name
Indonesian Journal Of Chemistry
Preparation, Characterization, and Biological Activity of La(III), Nd(III), Er(III), Gd(III), and Dy(III) Complexes with Schiff Base Resulted from Reaction of 4-Antipyrinecarboxaldehyde and 2-Aminobenzothiazole
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The research includes the preparation of several complexes of the internal transition elements lanthanide (Ln = La, Nd, Er, Gd, and Dy) containing the 4f shell, with Schiff bases resulting from condensation reactions between 4-antipyrinecarboxaldehyde and 2-aminobenzothiazoles. Schiff's base was identified using FTIR spectra, UV-vis spectroscopy, elemental microanalysis CHNSO, nuclear magnetic resonance, mass spectrometry, and TGA thermal analysis. The complexes were studied and identified with elemental microanalysis CHNSO, FTIR spectroscopy, UV-vis spectroscopy, TGA thermal analysis, conductivity measurement, and magnetic sensitivity. The result showed that these complexes were classified as homogeneous bidentate complexes with th

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Publication Date
Tue Jun 01 2021
Journal Name
Swarm And Evolutionary Computation
A review of heuristics and metaheuristics for community detection in complex networks: Current usage, emerging development and future directions
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