To follow up the response of acute lymphoblastic leukemic
(ALL) patients to chemotherapy treatment and for prognosis, diagnosis, the total Sialic acid (TSA) levels was studied as a tumor marker. The study included 40 patients (male = 22, female =18) with (ALL) were tested for the serum and leukocytes homogenate concentrations of total sialic acid (TSA) before and after treatment with six different chemotherapy protocols. While significantly increased ( P< 0.001 ) as compared to the heal thy individuals group, serum and leukocytes homogenate TSA concentrations dropped significantly ( P<O.OOl ) after treatment with each of the six chemotherapy treatment protocols, as compared to ALL untreated
patients. A linear correlation relationship ( r2 = 0.951 4 ; r2 = 0.9451)
was found between TSA concentrations and the period of chemotherapy treatment in serum and leukocytes homogenate. A linear correlation relationship (r2 = 0.9965) could be found between percentage of serum total sialic acid and percentage of leukocytes
homogenate total sialic acid. The results of this study strongly support the role of TSA as a marker for the disease and suggest that it could be used for progression and prognosis of ALL patients, in addition we strongly suggest that there was a positive relationship between TSA level in serum and leukocytes.
