Levetiracetam (LEV) is new antiepileptic drugs (AEDs), usually used with other drugs in case of inadequate control of seizures. It is usually discharge with the breast milk. This study was conducted for the evaluation of the effect of levetiracetam on the kidney after 3 and 7 day newborn albino rats (Rattus rattus). A total of 20 rats were taken which were divided into two groups (A/control and B/ treated). The rat pregnant group (A) represents control group which has given distilled water orally during the pregnancy period and continued in taking of till one week newborn and (B) represents treated groups the drug was administered (350 mg/kg/day) orally during the pregnancy period and continued in taking of drug till one week newborn. The statistical analysis of the result revealed that the mean values of the glomeruli diameter at 3 and 7 days newborn of the treated groups showed significant increase (p<0.05), and the mean values of the renal tubules diameter at 3 days newborn of the treated groups showed no significant increase (p≥0.05), but at 7 day newborn of the treated group showed significant increase (p<0.05). Histological study of the kidneys in treated group at 3, 7 days newborn, showed histopathological effect of kidney tissue represented by cortex damage where glomerulus emerged (degeneration , loss there nucleus, glomerular dead cell , small in size, glomerular cells accumulation and enlargement space was present between the glomerulus and glomerulus space , shrinking and atrophy of glomerulus). As well as, the damage was evident in the medulla where tubules emerged (swelling epithelial cells of collecting tubules , enlargement in size together narrow space between the proximal convoluted tubule, degeneration of collecting tubules , loss there nucleus and detached cells of collecting tubule from basement membrane). This study disclosed that LEV can induce already not reported severe malformation if it is used constantly through the implantation, an organogenesis stages of pregnancy. Therefore, it is proposed that great caution should be practiced in using LEV during the early stages of pregnancy until further studies are performed to better understand these effects.
The present study aimed to investigate the morphological description and histological structure of kidney in adult albino mice (Mus musculus), The anatomical study revealed that the kidney in albino mice is represented by bean-like shape, smooth with red to brown color, It is situated within the anterior half of abdominal cavity under the diaphragm on both sides of vertebral column. The kidney is covered by capsule of loose connective tissue with mean thickness of (9.6±0.5) micrometer. Histological examination revealed that albino mice kidney tissue differentiated into cortex and medulla, the cortex contains glomeruli with mean diameter of (50.5±1.9) micrometer densely distributed at the peripheral area of the cortex ,
... Show MoreBackground: doxorubicin is one of the most active cytotoxic agents in current use, it has a very potent effect in the treatment of various malignancy either used alone or combined with other cytocidal agents, the antitumor activity of this drug associated with cytotoxic effect such as cardiotoxicity, hepatotoxicity, nephrotoxicity, myelosuppression.
Objectives: - this study was designed to investigate the effect of the doxorubicin on the histological structure of the rats' kidney.
Results: - Doxorubicin cause reduction in the body weight and changes in the histological structure of the kidney which are atrophy of some glomeruli with
The aim of present study was to investigate the effect of Pregabalin on hormonal profile of pituitary and ovarian hormones in female albino rats. Three groups of healthy adult female albino rats having fifteen rats in each group were selected for present study. The rats of groups G2 and G3 were administered with Pregabalin with two doses 150 mg and 300mg/kg b.wt/day respectively by orally route daily for 1month, 2 months, and 3 months. Animals of group G1 (Control) were given saline alone. After the experimental periods, the rats were sacrificed, and the study of hormonal profile was carried out by collecting blood samples from the heart puncture method, centrifuged sera and analyzing concentrations of estrogen, progesterone and gonadotropi
... Show MoreSome types of the fungus Aspergillus were isolated from some hospitals in the city of Baghdad (Imam Ali Hospital and Sadr General Hospital). The samples were taken by Transport media at a rate of three replicates of each place isolated from samples from different places within the hospital (waste, baths, the sick beds, corridors and room floors) for the purpose of isolating and diagnosing the fungus on the Czapeck Dox Agar media. It was noticed that the spread rate of fungus Aspergillus was 70% compared to other species that have emerged during the isolation process of the Sabouraud's Dextrose Agar media. The species A.niger (56.25%) was considered the most common type of fungus visible during the isolation process of the Imam Ali Hospit
... Show MoreThe potential use of bone marrow stromal cells as a cellular therapy for chronic diseases relies on the ability of the cell to replicate extensively in vitro.For this reason the present study investigated the replication lifespan and examined the growth properties of albino rats mesenchymal stem cells(MSCS)in vitro. To establish an in vitro system for isolating and culturing the MSCs of albino rats and to provide research data for its further application,the bone marrow (BM)was collected from young male rats and separated by gradient centrifugation.Then, the mononuclear cells(MNCs) were retrieved from the buffy layer and cultured in Modified Eagle,s Medium (MEM) supplemented with 10%Fetal Calf Serum (FCS)and incubation
... Show MoreThis study was aimed to investigate the effects of Cuminum cyminum seed aqueous extract on the function and histological structure of rat kidney treated with dibutyl phthalate (DBP). Eighteen albino rats weighing 190-240g and aged 10-12 weeks were used for this study which went on for 28 days. The rats were divided into three groups (each with six animals): 1st group: control rats were given food and tap water, 2nd group was given DBP (420mg/Kg. B.W.) with tap water and diet, 3rd group were fed cumin plant orally at a daily dose of (200 mg/kg B.W.) and DBP (420mg/kg. B.W.) was given with drinking water and fed with diet daily. Kidney and liver function parameters were measured and hi
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In this study, the consequences of treatment with brake pad particles on kidney and spleen were evaluatedthrough microscopic anatomy sections for 60 male albino mice. The animals were divided into six groups, the first three groups (A,B,C) were exposed to brake pad particles depending on periods of exposure (4, 8, and 12weeks, respectively), while the other three groups were control groups,designated asF, which were exposed to laboratory fresh air only. A special locally-designed inhalation chamber was used to expose the animals. The exposure dose to brake pad particles (total suspended particles) was 2.228 µg/m³ for 30 min/day, 5 days/week,4, 8 and 12 weeks.The statistical analysis showed that the weights of organs for both
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The present study aimed to investigate the histological changes of heart, lung, liver and kidney which caused by different concentrations (10, 20 and 40 mg/kg) of Ivabradine. Results of the study revealed some histological changes represented by aggregation of the lymphocytes around respiratory bronchioles of the lung. In the liver, the drug caused hepatocyte necrosis and infiltration of the lymphocytes. In Kidney, there are no histopathological modifications in the tissue after the animals treated with 10 mg\kg of Ivabradine. When the animals treated with Ivabradine drug at 20mg/kg of bw, dose showed vascular congestion between myocardial fibers of heart. Emphysematous c
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the current study Included, evaluation the impact of Nitrofurantoin drug on liver in albino mice, 128 male albino mice have been used . Animals treared with (150,200 Mg/Kg) for 8 weeks . NFI caused histological changes in liver represented by , swelling of hepatocytes, disappearance of radial arrangement , vaculation of liver cells , increasing of kupffer cells and appearance of giant cells. NFT caused Congestion of blood vessels and infiltration of inflammatory cells in liver in all used concentrations.
The objective of present study is to identify the adverse effects of cyclosporine A drug and the protective role of garlic in cytotoxicity test, including sperms deformation and histological changes in testes tissues of male albino rats. The study recorded significant increase p≥0.05 in sperms head and tail deformation rates in groups that were administrated cyclosporine and cyclosporine + garlic for two weeks compared with control groups which were administrated olive oil and garlic. The study reported significant decrease p≥0.05 in sperms head and tail deformation rates in the group that was administrated cyclosporine + garlic compared with group that was administrated cyclosporine only. In addition, the study also indicat
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