A simple, rapid, accurate and sensitive spectrophotometric method is proposed for the detennination of chlorprQm<tZine -HCl in pwe form and in pharmaceutical formulation. This method is based on the formation. of ion assodation complexes of dmg with either thymol
blue or bromophenol blue in an acidic buffer at pH values 4.17 and
3.68, respectively.
The ion-pair complexes formed exhibit absorption maxima at 41 Onm for both thymol blue and bromophenol blue. These complexes· are quantitatively extracted with chloroform. The calibration graphs are tmear and obeyed Bee 's law in a cort.ce n:at_ion range of 50-450fg!ml and H:}-120)lg/ml w1th molar absorptttvttes of L0374xl0 and
1.7613xl03 Lmorcm·1 for thymol blue ,and bromophenol blue,
respectively.
Statistical treatment of the experimental results indicated that the method is precise, accurate and the procedure was successfully applied to the determination of the bulk drug and its pharrnaceutic;al fpnnulations.
