The issue of nuclear proliferation is one of the most vital issues as it reflects a form of dealing in the field of international relations. Therefore, the Middle East region has taken great interest in reducing the levels of nuclear armament and acquiring nuclear power within the strategic framework of the international and regional powers. The establishment of a nuclear-weapon-free zone in the Middle East region is currently one of the most important international and regional arrangements for controlling the levels of nuclear proliferation and attempting to build a state of stability and balance. In the Middle East and the world. The importance of the research comes from the fact that it deals with an important and vital issue: the issue of nuclear proliferation and its implications for the equation of the strategic balance in the Middle East after the events of September 11, 2001, which gained great importance in the post-cold war era. And to achieve some kind of stability and balance within the framework of the international and regional environment, especially in the Middle East, which has increased the importance of efforts in this regard the proliferation of nuclear weapons to new countries, it is possible to obtain nuclear technology by enhancing levels The proliferation of weapons of mass destruction has become one of the most important facts for the post-Cold War era. At a time when only five countries possessed nuclear weapons (the United States, Russia, China, France and Britain) , As well as the possibility of other countries such as India, Pakistan and Israel, which suggests that the post-Cold War era has seen a widening of the circle of States possessing or manufacturing such weapons (Pakistan, North Korea and Iran) The emergence of regional tensions as in the case of William Middle East. Thus, the issue of non-proliferation of weapons of mass destruction has become a central issue in the context of the post-Cold War American strategy, especially after the events of September 11, 2001, as a result of the convictions that there is an interrelationship between the non-proliferation of weapons of mass destruction and the global fight against terrorism. In keeping with this, the research started from the premise that the continuity of the Middle East countries in seeking to acquire nuclear capabilities is in itself an essential brake or determinant of the establishment of a zone free of weapons of mass destruction, as well as the lack of guarantees to establish security among countries The Middle East, which is reflected negatively on the regional and international security approaches to the Middle East, and of course lead to the adoption of their respective security policies against each other within the framework of the growing levels of nuclear weapons to achieve some kind of balance towards the nuclear capabilities of each of these countries And then more nuclear armament policies in the region, as a result can not promote positive security perceptions that are based on the employment of enablers of smart power, which is reflected negatively on the strategic balance in the territory of the Middle East equation. Keywords: nuclear proliferation, the Middle East, strategic balance, the events of September 11, 2001, regional and international security, doctrine of preemptive war, preemptive war, nuclear deterrence, strategic perception, terrorism, nuclear power Nuclear proliferation.