This study outlines the synthesis of substituted 1,2,4-triazole derivatives through the cyclization reaction of thiourea derivatives. The process begins with the reaction of different halides with KSCN to produce isothiocyanate derivatives. then followed by a reaction with isonicotinic acid hydrazide to yield thioureas (1-6), with a yield rate of (72-88%). Then, compounds (1-6) were treated with alkaline medium 4 N (NaOH) to produced 1,2,4-triazole derivatives (7-12) with a yield (51-69%).The structure of the prepared compounds was characterized using FTIR,1HNMR and 13CNMR spectroscopy. Some of the synthesized compounds were tested for antimicrobial activity when, compound 9 showed strong activity against gram positive bacteria (Sta

On the basis of known coumarin-based prodrug system, a novel coumarin-based mutual prodrug of 5-fluorouracil and dichloroacetic acid was designed, synthesized and evaluated as a promising oral chemotherapeutic agent basing on in vitro stability study in HCl buffer (pH 1.2) and in phosphate buffer (pH 7.4), as well as in vitro release study in human serum. The chemical structure of prodrug was confirmed by analyzing its FTIR, ¹H NMR, ¹³C NMR and MS-ESI spectra. The results of in vitro kinetic study indicated that the prodrug was significantly stable in HCl and in phosphate buffers, and was hydrolyzed in human serum followed pseudo first order kinetics.

Keywords: Coumarin-bas

The influence of sintering and annealing temperatures on the structural, surface morphology, and optical properties of Ag2Cu2O4 thin films which deposited on glass substrates by pulsed laser deposition method have been studied. Ag2Cu2O4 powders have polycrystalline structure, and the Ag2Cu2O4 phase was appear as low intensity peak at 35.57o which correspond the reflection from (110) plane. Scan electron microscopy images of Ag2Cu2O4 powder has been showed agglomerate of oxide particles with platelets shape. The structure of thin films has been improved with annealing temperature. Atomic Force micrographs of Ag2Cu2O4 films showed uniform, homogenous films and the shape of grains was almost spherical and larger grain size of 97.85 nm has o

The present researchers are trying to enhance the properties of paper sheet that used widely in many fields such as printing and packaging. The enhancement of paper quality is also possible to preserve paper documents of all kinds, as they are the true record, full of the history, achievements of the human being and the intellectual and cultural of the country. It is possible to improve its physical and mechanical properties and preserve them from damage through the use of some solutions of polymeric adhesives, which act as protective barriers against water and moisture penetration. The paper also has the advantage of porosity, which has been overcome by using three types of polymeric adhesives (Nitro Cellulose, Polyvinyl alcohol acetate, a

Continuous improvement, or Kaizen, is a philosophy that is based on the idea of continuously finding ways to improve things.  From this point of view, continuous improvement is not limited to the quality of products or services but it also applies to all the processes in the organization.  During the last two decades several continuous improvement approaches were developed and marketed.  The advocates of each approach claim that their approach is the best, however all the approaches had their own advantages and disadvantages and had their share of criticism.  The important question is how to choose the right continuous improvement approach?  This research work addresses the philosophy, the concepts, the assumptio

This research examines the electronic check slip of an educational doctrinal study, in terms of explaining the truth of the electronic check and the legal organization of it and the way it is handled, and then devising the jurisprudence related to it.

 In the research I dealt with the form of the preference verb, as well as the elements of the preference noun and its states in its abstraction from the and addition and its conjugation with (the) and its addition to the negation and knowledge. It is (good, evil, and love) omitting the hamza in it.

فسيفساء قبة الصخرة دراسة تحليلية

After this trip start to get interesting conclusion, conclusion and maintenance station,
the conclusion, where we summarize the most important findings:
1. We found that the triads are the conversations that will be assigned in three narrators
between the workbook and the Prophet.
2. The number of triangles is the Imam recaps (15) recently, and all true only recently one
well in the Book of Rites and the modern were weak in the book authorization and the Book of
Virtues of the Quran.
3. Triads varied in the ways of drama at the gates of Islamic jurisprudence, he may talk and
one each from the Book of purity and prayer, fasting, marriage and the tortillas and the virtues
of the Quran, and has had three conversat