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Diabetes mellitus is a multifaceted, chronic disease that happens either when the pancreas
does not produce enough insulin or when the human body cannot competently use the insulin
it produces. The study was aimed to determine and show the ultrastructural changes of cells in
the placenta of women suffering from diabetes mellitus disease. In this study, a total of 102
placentas were investigated by transmission electron microscopy, which includes 34 placentas
with gestational diabetes, 34 placentas with pregestational diabetes, and 34 placentas with
normal pregnancy as a control group. Placental vascular-syncytial membrane, trophoblastic
basement membrane, villous stroma, and fetal vessel were investigated for their thickening
basement membr
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