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Abstract: To study the effect of nickel chloride on bone composition of mice, a number of biophysical and
biochemical parameters have been made use. The animals were divided into control and experimental and
further subdivided into three groups I, II and III according to the dose of nickel chloride (NiCl2) administered
to them i.e. 5.8, 12.8 and 28.2 mg/kg body weight, respectively. Femur bones were obtained by sacrificing the
animals three weeks after weaning them once a week. The percentage loss between the wet weight and dry
weight of femur in control animals was found to be 32.5+1.5 .In the three experimental groups I,II and III, the
percentage loss was 30.4+1.4, 35.3+2.3 and 38.9+2.2 respectively. The percentage loss between the wet we
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