The art of pantomime mime is one of the arts that has taken a wide space in theater performances, and because it is one of the spectacle shows that relies on an acting performance that is unique from the traditional acting performance, because of the peculiarity of pantomime art in that it is a silent performance that assumes the clarity of meaning, and for the purpose of clarifying the actor’s work in such kind of performances, the art of pantomime must be We have to know the skills that the actor can possess in order to produce a silent show that has the elements of a successful presentation, so there was a need to study the skills of the actor in this type of acting performance. The researchers divided this study into an introduction in which they dealt with the research problem formulated in the following question: What is The performance skills that the actor has to master? Then the research objective and the definition of the study term. As for the theoretical foundation, it included two topics: the first topic (the development of the art of the pantomime) and the second topic (the technical skills of the representative of the pantomime). In 2006. Then the two researchers reached a set of results, including: The skill of completing each theatrical act before starting another theatrical act must be present with the actor so that the spectator does not confuse the description of the forms, the event and the story. Then a summary and sources of research in English.
EGFR-mutant non–small cell lung cancer (NSCLC) initially responds well to EGFR tyrosine kinase inhibitors (EGFR-TKIs), yet resistance is nearly inevitable and responses to immune checkpoint inhibitors (ICIs) remain limited. In a retrospective cohort of 57 patients with advanced EGFR-mutant NSCLC treated with nivolumab or pembrolizumab, the objective response rate was 12.3%, although responses were concentrated in a small subgroup with concurrent high PD-L1 expression and dense intratumoral CD8⁺ immune-cell infiltration. Emerging evidence links these outcomes to chemokine-network dysregulation that alters immune trafficking and spatial organization. Oncogenic EGFR signaling shifts chemokine networks away from effector T-cell recruitment
... Show MoreThis research examines the evolution of Turkey's foreign policy in dealing with international crises, especially after 2011, when Turkey shifted from a "zero problems" approach to a more active and interventionist foreign policy in regional issues, such as the Syrian crisis and the Eastern Mediterranean crises. The importance of this study lies in its focus on the experience of a regional power in a turbulent environment, reviewing Turkey's success or failure in managing these crises through various tools. This study focuses on outlining the theoretical framework of the concept of international crisis management, analyzing Turkey's tools for dealing with crises, studying the practical models of Turkey's role in regional crises, and
... Show MoreThe rapid spread of the COVID-19 coronavirus in 2019 infected many people, primarily affecting the respiratory system. Both COVID-19 and type 2 diabetes have been associated with numerous risks that have become life-threatening. The study studied the link between galectin levels and some clinical characteristics in Iraqis with type 2 diabetes and COVID-19 against those without diabetes. The study included 120 patients and healthy men. Three groups were formed for this study depending on the initial mutant cell line: 80 samples of individuals with type 2 diabetes, aged 40–60 years, with and without COVID-19, were included in each of the first and second groups. The control group consisted of 40 research participants who were matched for ag
... Show MoreObjectives: This study investigates the U.S.-China competition in the field of artificial intelligence (AI), focusing on its implications for both countries’ military strategies. It also offers a forward-looking assessment of how this rivalry may influence international security and geopolitical stability. Methods: The research adopts an integrative theoretical framework combining realism—which emphasizes military power and strategic dominance—and technological innovation theory, which highlights the role of emerging technologies in global power shifts. A descriptive and analytical approach is employed, synthesizing academic literature, policy reports, and strategic documents from 2010 to 2030. Results: The U.S.-China AI compe
... Show MoreTicagrelor (TCG) is an effective P2Y12 receptor antagonist used to prevent atherothrombotic cardiovascular events; however, its poor solubility and limited permeability (BCS Class IV) restrict its oral bioavailability. Spanlastic Nanovesicles (SNVs), composed of nonionic surfactants and edge activators, offer a promising strategy to enhance drug solubility and permeability. This study aimed to develop and optimize TCG-loaded SNVs using the ethanol injection method, validate a sensitive HPLC method for TCG quantification, and evaluate the pharmacokinetic and antiplatelet performance of the optimized formulation in rats.
Massive efforts have been focused on designing of new anticancer medications. One of these approaches is inhibiting histone deacetylase (HDAC) which have a major role in regulation of cellular epigenetic processes. The non- selectivity of HDAC inhibitors is the major limitation for their use, therefore, recent researches have been oriented toward introducing of selective(HDAC) inhibitors through inhibition of HDAC2 and HDAC6 enzymes. A set of pyrazoline derivatives was designed and virtually studied by means of molecular docking, ADME, and molecular dynamics (MD) simulations. Compound 5 showed promising virtual binding affinity on the HDAC 2 and 6 inhibitors, and exhibited more in silico affinities to (4LXZ)& (5EEI) respectively than SAHA.
... Show MoreBovine theileriosis, caused by Theileria annulate, is disease affecting cattle and buffaloes worldwide. The current study aimed to screen the blood samples of 30 naturally suspected local buffaloes infected with Theileria species. The blood samples were initially examined by light microscopic and then the positive samples were subjected to PCR reactions. All 30 animals indicated clinical symptoms, such as high fever, loss of appetite, the presence of the hard tick, and enlargement of lymph nodes. The amplified products of 18S rRNA were analyzed, along with molecular detection of the drug-binding site alterations and interrelated changes in the cytochrome b (cyto b) gene. Blood smears revealed the presence of infected erythrocytes wi
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