Background: In recent years, the immediate loading of dental implants has become more accepted as a standard protocol for the treatment of the edentulous area. Success in implant dentistry depends on several parameters that may improve phenomenon of osseointegration and new bone formation in close contact with the implant. The aim of study was to evaluate the effect of strontium chloride coating of screw shape commercially pure titanium dental implant osseointegration at bone - implant interface by histomorphometric analysis and compare with hydroxyapatite coating at 2 time periods (2 weeks and 6 weeks). Materials and methods: Electrophoretic Deposition Technique (EPD) was used to obtain a uniform coating layer on commercially pure titanium screws. The tibia of 4 white New Zealand rabbits was chosen as implantation sites. Each tibia of rabbit received two screws, one strontium chloride coated and one hydroxyapatite coated and a total 30 histological sections were obtained for each coating material in each period of time. Histomorphometric analysis was performed to measure new bone formed ratio between implant and original bone, after 2 and 6 weeks healing periods. Results: There was increased in new bone formation ratio for the strontium chloride coated implants than hydroxyapatite coated implants and over the two periods of time. There was an increase in the new bone formation ratio at bone-implant interface with time. Conclusion: Coating commercially pure titanium implant with strontium chloride was more efficient in increasing osseointegration at bone implant interface than hydroxyapatite , which was demonstrated by higher new bone formation and maturation at the two periods of time 2 weeks and 6 weeks after implantation. Keywords: Histomorphometric, commercially pure titanium, strontium chloride, hydroxyapatite.