Background: Oral squamous cell carcinoma is the most prevalent malignant neoplasm of the oral cavity which results from accumulated genetic and epigenetic alterations. It is not always inexorable and may be reversible if early intervention in the process can occur to prevent further genetic mutation and disease progression. The FHIT gene is a tumor suppressor gene located in FRA3B region which is the most active common fragile site, where DNA damage leading to aberrant transcripts and translocations frequently occur. The WWOX is a tumor suppressor gene that plays a central role in tumor suppression through transcriptional repression and apoptosis, with its apoptotic function the more prominent of the two. This study aimed to evaluate and compare the immunohistochemical expression of FHIT and WWOX in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma and to correlate the expression of the mentioned markers with the clinicopathological features and to show the expression of studied markers with each other. Materials and methods: Fifty formalin-fixed, paraffin embedded tissue blocks (10 cases of normal oral mucosa, 19 cases of oral epithelial dysplasia, and 21 cases of oral squamous cell carcinoma) were included in this study. Immunohistochemical staining was performed using anti FHIT polyclonal antibody, and anti WWOX polyclonal antibody. Results: Positive IHC of FHIT was detected with high score in all cases of NOM, 16 cases (84%) of OED and 18 cases (86%) of OSCC. For WWOX expression positive IHC detected with high score in all cases (100%) of NOM, 14 cases (74%) of OED and 15 cases (71%) of OSCC. There was statistically highly significant correlation of both markers in OED and non significant correlation in OSCC, with significant differences among studied groups. Conclusions: These results signifying both markers cooperative tumor suppressive role and potential pathological transition from normal oral mucosa to dysplastic epithelium and subsequently cause malignant oral lesions.
In this paper, the problem of scheduling jobs on one machine for a variety multicriteria
are considered to minimize total completion time and maximum late work. A set of n
independent jobs has to be scheduled on a single machine that is continuously available from
time zero onwards and that can handle no more than one job at a time. Job i,(i=1,…,n)
requires processing during a given positive uninterrupted time pi, and its due date d
i.
For the bicriteria problems, some algorithms are proposed to find efficient (Pareto)
solutions for simultaneous case. Also for the multicriteria problem we proposed general
algorithms which gives efficient solutions within the efficient range
134 samples of plants and animals wastes were taken from three different regions outside Baghdad and three different regions in Baghdad. 24 cellulolytic isolates fungi AO, C1, TH1, AN1, R1, TV, PG, AF, B1, L1, AP, TH, AP1, AN3, AO2, A, A1, C, F, AO1, C2, F1, CL and AP2 independent were chosen out of 48 selected fungi. The best optimal conditions for growth were 30ºC and pH 7. The isolates were identified and screened according to the colony diameter, biomass and density of spores in addition of capability to produce the hydrolytic enzymes for cellulose.
Recently, digital communication has become a critical necessity and so the Internet has become the most used medium and most efficient for digital communication. At the same time, data transmitted through the Internet are becoming more vulnerable. Therefore, the issue of maintaining secrecy of data is very important, especially if the data is personal or confidential. Steganography has provided a reliable method for solving such problems. Steganography is an effective technique in secret communication in digital worlds where data sharing and transfer is increasing through the Internet, emails and other ways. The main challenges of steganography methods are the undetectability and the imperceptibility of con
... Show MoreLet be an associative ring with identity and let be a unitary left -module. Let be a non-zero submodule of .We say that is a semi- - hollow module if for every submodule of such that is a semi- - small submodule ( ). In addition, we say that is a semi- - lifting module if for every submodule of , there exists a direct summand of and such that
The main purpose of this work was to develop the properties of these classes of module.
The useful of remote sensing techniques in Environmental Engineering and another science is to save time, Coast and efforts, also to collect more accurate information under monitoring mechanism. In this research a number of statistical models were used for determining the best relationships between each water quality parameter and the mean reflectance values generated for different channels of radiometer operate simulated to the thematic Mappar satellite image. Among these models are the regression models which enable us to as certain and utilize a relation between a variable of interest. Called a dependent variable; and one or more independent variables
In this paper, the combined source coding with Multi Carrier Code Division Multiple Access (MC-CDMA) system is proposed, where the transmission of the compressed image produced from source coding through Additive White Gaussian Noise (AWGN) channel for a single user and multi users. In which the (MC-CDMA) system removes Inter Symbol Interference (ISI) and Inter Carrier Interference (ICI). The hybrid compression system of Discrete Cosine Transform (DCT) and predictive coding (PC) technique are integrated as a source coding. The simulation results indicates that the transmission system of a single user was much better than the transmission system of multi users. When the number of users increased, the Bit Error Rate (BER) increased. For a
... Show MoreThe Mannich reaction is one of the most important types of organic chemistry fundamental reactions. It is a crucial stage in the production of various medicines, natural goods, and industrial chemicals. Chemists' imaginations have always been piqued because of this. In general, the Mannich reactions can be used as part of a tandem reaction sequence to produce complex target molecules in an elegant and often easy manner. The following article examines and summarizes methods for synthesizing Mannich derivatives, in addition to offering a survey of recent advancements in several fields’ applications of the Mannich reaction, such as biological applications, antimicrobial activity, anticancer activity, anti-inflammation and antio
... Show MoreThe present study deals with the story of Epidemic in two literary works issued in the same year (1947). One of them is a novel titled "Plague" written by the French writer Alber Kamo, the second is a poem of the Iraqi poetess Nazik Al-Malaekah. The research reflects a contrastive study of the war vision in the two works as both writers used science to serve literature by using Epidemic as a metaphor to refer to the dangers that the societies faced.
The problem of the present research lies in answering the question about the reason that makes the two writers use metaphor while narrating the issues of the society instead of mentioning them directly and illuminate what implications do the narrative style of Epidemic story have and
... Show MoreRKASFH Ghanim, Ibn Al -Haitham Journal for pure and applied science, 2017