Background: Tooth decay is still one of most common diseases of childhood, child’s primary teeth are important even though they aretemporary. This study was conducted to assess the physiochemical characteristic of saliva among caries experience preschool children and compared them with caries free matching in age and gender. Then an evaluation was done about these salivary characteristics to dental caries and evaluated the relation of body mass index to dental caries and to salivary variables. Materials and method: After examination 360 children aged 4-5 years of both gender. Caries-experiences was recorded according to dmfs index by (World Health Organization criteria 1987) during pilot study children with caries experience was divided in to three groups according to decay fraction of decay missing filled surfaces index .Mild with decay surfaces<6, moderate with 6≤decay surfaces≤13 and severe with decay surfaces>13 and select thirty children with moderate caries experience and compared with thirty caries free children decay missing filled surfaces=0 match in age and gender. Nutritional status of each child was assessed by measuring weight and height to calculate body mass index. Unstimulated saliva collected from sixty child under standardized condition and potential hydrogen and flow rate were measured. Total antioxidant concentration, total protein, calcium, inorganic phosphorus, zinc and copper were measured. Results: Statistically highly significant differences were found in concentration of salivary calcium and inorganic phosphorus between caries-experience and caries free children with higher mean value among caries free group. Statistically significant differences were found in concentration of salivary zinc between groups. Statistically non-significant differences were found in concentration of salivary total antioxidant, total protein, copper and body mass index between caries experience and caries free groups.Salivary flow rate and PH showed statistical non-significant differences between groups. Positive non-significant correlation was found between dmfs index, (ds) fraction of dmfs index and salivary flow rate, total antioxidant and negative correlation with salivary PH, total protein, calcium, phosphorus, zinc and copper. Positive a non-significant correlation was found between BMI, salivary flow rate, PH, total antioxidant, zinc and copper while a negative weak correlation found with dmfs, ds fraction of index and salivary total protein, calcium and inorganic phosphorus in caries experience group. Furthermore a non-significant positive correlation was found between BMI, salivary flow rate, PH, total antioxidant inaddition to that negative weak correlation was found with salivary total protein, calcium inorganic phosphorus, zinc and copper among caries free group. Conclusion: The findings of the present study showed that inorganic components of saliva play an important role in reminerlization of incipient caries and there is an inverse association between body mass index and dental caries.
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Invasomes are newly developed types of nanovesicles. A vesicular drug delivery system is considered one of the approaches for transdermal delivery to enhance permeation and improve drug bioavailability. Ondansetron is a serotonin receptor antagonist used for treating vomiting associated with different clinical cases. The study aimed to prepare invasomal dispersions for improving permeation of ondansetron across the skin with a controlled release pattern. Twenty-seven formulas of ondansetron-loaded invasomes were prepared by a modified mechanical dispersion method. These formulas were optimized by studying the effect of variables on entrapment efficiency. Vesicle size, polydispersity, zeta potential, in-vitro release and ex-vivo perm
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Currently, there is an intensive development of bipedal walking robots. The most known solutions are based on the use of the principles of human gait created in nature during evolution. Modernbipedal robots are also based on the locomotion manners of birds. This review presents the current state of the art of bipedal walking robots based on natural bipedal movements (human and bird) as well as on innovative synthetic solutions. Firstly, an overview of the scientific analysis of human gait is provided as a basis for the design of bipedal robots. The full human gait cycle that consists of two main phases is analysed and the attention is paid to the problem of balance and stability, especially in the single support phase when the biped
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The members of the family of Eentrobacteriaceae harbour a gene cluster called polyketide synthase (pks) island. This cluster is responsible for the synthesis of the genotoxin colibactin that might have an important role in the induction of double-strand DNA breaks, leading to promote human colorectal cancer (CRC). Eleven out of the eighty eight isolates (12.5%) were pks+, distributed as 7 (8%) isolates of E. coli, 2 (2.25%) of K. pneumoniae and 2 (2.25%) of E. aerogenes. The cytotoxic effects of selected pks+ isolates (E. coli and E. aerogenes) on HeLa cells were represented by decreasing cell numbers and enlarged cell nuclei in comparison to the untreated cells. Cytological changes were observed when the infected HeLa cells culture
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This research delves into the realm of asphalt technology, exploring the potential of nano-additives to enhance traditional asphalt binder properties. Focusing on Nano-Titanium Dioxide (NT), Nano-Aluminum Oxide (NA), and Nano-Silica Oxide (NS), this study investigates the effects of incorporating these nanomaterials at varying dosages, ranging from 0% to 8%, on the asphalt binder’s performance. This study employs a series of experimental tests, including consistency, storage stability, rotational viscosity, mass loss due to aging, and rheological properties, to assess the impact of nano-additives on asphalt binder characteristics. The findings indicate a substantial improvement in the consistency of the asphalt binder with the add
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