Background: Potentially malignant oral disorders (PMODs) are common precursors of oral squamous cell carcinoma (OSCC). Neoangiogenesis and signalling are important intermediate biomarkers that may govern the progression of dysplastic mucosa into carcinoma. Aims: Evaluate the importance of CD34 and Wnt3 expression in PMODs and OSCCs in relation to their clinicopathological parameters. Settings and Design: Prospective cross-sectional study. Materials and Methods: Immunohistochemical staining for CD34 and Wnt3 was performed for 41 samples. These included 27 PMODs, six OSCCs and eight normal gingival and alveolar mucosa. Analysis of variance (ANOVA) and post-hoc tests were applied. P<0.05 was considered statistically significant. Results: CD34 expression showed a significant difference between groups (P<0.05). CD34 expression decreased in patients who had PMODs, and it was seen to correlate with clinical staging in OSCC patients. The alveolar epithelia had lower microvessel density (MVD) (9.3±.88) than the gingiva (17.47±5.09) (P<0.05), whereas the lichen planus without dysplasia had lower MVD (8.85±3.95) than both the gingiva and the dysplastic epithelia (14.46±3.89) (P<0.05). On the other hand, Wnt3 expression was not detected in the alveolar mucosa, but scattered perinuclear and nuclear expression in the gingival mucosa was observed. Cytoplasmic Wnt3 expression was seen in all oral lichen planus (OLP) and some leukoplakia cases with no nuclear staining, whereas its expression in proliferative verrucous leukoplakia was only nuclear. Furthermore, OSCCs showed both cytoplasmic and nuclear expression. Conclusion: MVD may represent a useful biomarker preceding oral cancer development. It increases from normal mucosa to dysplasia to carcinoma. Aberrant cytoplasmic expression of Wnt3 is detected in PMODs and OSCCs. Thus, Wnt3 may be involved in disease progression.
DBN Rashid, Talent Development & Excellence, 2020
The platelet activity and some immunological aspects of
coronary heart disease CIID were investigated by employing platelet count and serum levels of IgG,IgM and lgA,C3 and C4.Three groups of patients were investigated : patients with ischemic heart disease IHD, patients with lliD+hypcrtension and patients with IHD+unstable angina.The results revealed that the mean of platelets (mm') was significantly reduced in IHD+unstable angina group
2.72.L I.l2 compared with conrol b'TOUp 8.13±2.72.
With respect to the immunological study, the re;;ults revea
... Show MoreProverbs and preaching Sermons in Pre-Islamic Poetry and their indications Peacefulness
Abstract Drug addiction is considered a criminal behavior, which led the Iraqi legislator to prohibit and criminalize it, imposing penalties on those who use or even approach it. This aims to limit its presence in Iraq and reduce unethical behaviors, leveraging the divine prohibition to curb it. The legislator also encourages media organizations to raise awareness about the dangers of this substance, which has contributed to reducing the phenomenon of drugs in Iraq.
This study was performed at Nuclear Radiation Hospital in Baghdad for the period from
January 2011 to May 2011. 44 Blood samples were collected from patients suffered lung and
bladder cancer and 24 samples as healthy control individuals.
Routine liver functions tests were studied by measuring S.GPT, S.GOT and Kidney
function was evaluated by estimation of blood urea and creatinine in serum samples of
individuals studied.
It was observed that the incidence of lung and bladder cancer was higher in males than
females patients ( male 81.82 %, 72.73%, female18 .18%, 27.27% respectively).
Insignificant difference was noted among age of lung and bladder cancer patients
compared with control group. The results
The study showed that Imam Said bin Jubair narrated in the transcriber and copied, which took most of the ink of the nation Ibn Abbas (may Allah be pleased with them), which amounted to fourteen novels.
The study also pointed out that the science of transcriber and copied is from the science of the Koran, which can only prove by the novel and the correct transmission of the Prophet Muhammad .
The study also showed that Imam Saeed bin Jubair, who says that it is permissible to copy in the Koran, contrary to what some scholars said that it is not permissible to copy.
The study also pointed to the possibility of copying and that the highest copies of the Koran Koran.
This study includes replication and attenuation of foot and mouth disease virus type O which isolated from infected calves. Many passages for the virus in chick-Embryo were established as a substitute method to the tissue culture which is highly caustic in contrast to the chick embryo. The virus passed ten consequent passages which lead to the reduce of the titer of the virus from 106.53 TCID50/ 0.1 ml in cattle testis tissue culture to 103 TCID50/ 0.1 ml. the pathogenecity of attenuated FMD virus were also studied in both chick-embryo and guinea pigs. Using agar gel diffusion test precipitation antibodies was detected in guinea pig serum after 14 and 21 days post exposure to the attenuated virus. The inoculated guine
... Show MoreGod saw his servants with truth and light, and made him easy for them, and he commanded those who help them, including a counselor, guide and preacher, so if a Muslim sees deficiencies or defects, he must help him to reform and refine it. That it was in the hands of the prophets, God Almighty created the human being together straight, then melted on those scholars and researchers in all religions on psychological counseling and religious sychotherapy, stressing the importance of religious values in the process of understanding man in the process of psychotherapy and in controlling human behavior. A lot of research and studies have been published. I dealt with the religious approach in the process of treating mental disorders and the aim of
... Show MoreActinomycetes are free, spore-forming, high (G+C) ratio (>55%) saprophytic microorganisms that are widely distributed in most soils, colonize plants, and are prevalent in water. This is frequently accompanied by the production of filament airborne mycelium. Actinomycetes are well-known microcolonies for creating antibiotics and other critical bioactive components that are beneficial to humans. Approximately 70% to 80% of commercially available medications and antiviral active compounds have been synthesized so far. Secondary metabolites produced by microbes have the potential to be used in a variety of sectors, including antimicrobial agents, enzyme technology, pigment manufacture, antitumor agents against cancer cells, and toxin pr
... Show MoreObjective To investigate the accuracy of gingival crevicular fluid (GCF) E-cadherin and total antioxidant capacity (TAC) to discriminate periodontal health from disease. Subjects and Methods GCF samples were collected from participants with periodontal health (control), gingivitis, and periodontitis (n = 25 each group). The latter group was further subdivided according to stage (S) and grade. Periodontal parameters were recorded then levels of biomarkers were assayed using ELISA and antioxidant status by use of the Total Antioxidant Capacity Assay for E-cadherin and TAC, respectively. Results All periodontal parameters were significantly higher in periodontally diseased groups than controls. The GCF E-cadherin significantly increased
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