Background: Preparation of platelet-rich fibrin (PRF) is a simple, low cost and minimally invasive method to obtain a natural concentration of autologous growth factors that is widely used to accelerate soft and hard tissue healing, thus, PRF is used in different fields of medicine. The aim of this study was to evaluate the effect of local application PRF on stability of dental implants. Materials and methods: nineteen healthy patients with adequate alveolar bone with two or more adjacent missing teeth and/or bilaterally symmetric to the midline (split-mouth design) missing teeth participated in this study. Each patient received at least two dental implants (Dentium Co., Korea). After surgical preparation of the implant sockets, the PRF was applied randomly into one of the implant socket before the placement of implant fixture) study group), while the second implant was inserted without PRF (control group). The implant stability was measured by resonance frequency analysis (RFA) using OsstellTM ISQ, at the time of surgery (primary stability), and at 4, 8 and 12 weeks postoperatively (secondary stability). Results: Although in the three records of secondary stability, the mean implant stability quotient (ISQ) in the study group was higher compared to the control group, this elevation was statistically not significant (P value > 0.05). On the other hand, PRF showed a significant effect on implants stability by 2.367 folds for implants that achieved primary stability ≥ 70 and maintained this stability after 12 weeks. Conclusions: Within the limitations of this study, local application of PRF exhibited that there was no statistical beneficial effect on implant stability. No significant correlation was found between local bone density and implant stability in both groups.
