Background: Chronic myeloid leukemia is a cancer of the white blood cells characterized by the increased and unregulated growth of predominantly myeloid cells in the bone marrow. This study aimed to determine the effect of chronic myeloid leukemia on Dental caries and Oral health status including Gingivitis, Loss of attachment, Plaque index and Calculus index as well as evaluation of salivary flow rate and salivary interleukins-6 and tumor necrosis factor-?. Material and methods: Study group consisted of (75) subjects, (25) were newly diagnosed with chronic myeloid leukemia, (25) were taking medications (Glevic), and (25) were control subjects, all aged 45-55 years old. Collection of stimulated salivary samples was performed under standard conditions, then salivary flow rate and salivary cytokines estimation was done. Clinical examination and oral health assessment were carried out under the standardized conditions of oral health surveys of World Health organization. dental plaque was scored according to the criteria of plaque Index by Silness and Loe(1964), Dental calculus was scored following the criteria of calculus component of the periodontal Index (Ramfjord, 1959), assessment of gingival health done according to the criteria of gingival Index for Loe and Silness (1963) and loss of attachment done following the criteria of WHO (1997). Caries assessment was done according to the WHO modified Decayed-Missing-Filled Index (DMF) and examination was done with a plane mouth mirror and CPI probe. Results: DMFS index were higher in the newly diagnosed group followed by the control group and then the treated group but the LSD test showed that differences were statistically not significant between each two groups, Plaque index was higher in the newly diagnosed group, and the differences were statistically significant only between the newly and the control group (p<0.05), Calculus index was higher in the newly diagnosed group and the difference was statistically significant between the newly diagnosed group and the treated group. Gingival index was higher in the control group and the difference was statistically highly significant between the new and control groups (p<0.01) and also highly significant between control group and the treated group. Loss of attachment index was higher in the control group the LSD test show that the difference was statistically significant between the control group and each one of the other two groups. In regard to saliva, salivary flow rate was higher in the control group; the difference was significant between the control and the newly diagnosed group and highly significant between control and the treated group. Interleukin-6 level was higher in the newly diagnosed group then the treated group then the control group. LSD test show that the difference was statistically significant between the new and the treated group (p<0.05) and it was highly significant between the new and the control group (p<0.01) but it was not significant between the treated and control group. TNF-? level was higher in newly diagnosed group followed by the treated group then the control group and the difference was statistically significant with the treated group and highly significant with the control group, but the difference was not significant between the treated and the control group. Conclusion: Salivary Interluekine-6 and Tumor necrosis factor- ? levels were higher in the newly diagnosed group. Saliva provides an ideal tool for the detection of pro-inflammatory markers. Salivary IL-6and TNF-? may play an important role as biomarkers for CMLand IL-6 is more predictable for the response to the treatment than TNF-?.
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ناقش البحث في طياته عدداً من القضايا الرئيسة المتعلقة بالتقييم الاستراتيجي والإطار العام للخطة الاستراتيجية المقترحة لشركة نفط ميسان للسنوات الخمس المقبلة (2020_2024)، وهدف هذا البحث يتمحور في تقييم عملية صياغة استراتيجية شركة نفط ميسان لتحديد نقاط القوة وتعضيدها ومواطن الضعف ومحاولة معالجتها لتجنب الوقوع بها عند وضع استراتيجية للسنوات القادمة، وعلى هذا الاساس فان مشكلة البحث تكمن في مدى نجاح الاستراتي
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This study was conducted to determine the effects of concentration of hydrochloric acids, temperature, and time on the hydrolysis of soya proteins (defatted soya flour) by determining the value of total protein nitrogen concentration, and amino nitrogen concentration of protein, peptides, and amino acids, and then calculated the hydrolysis rate of proteins.
The variables of the conditions of hydrolysis process was achieved in this study with the following range value of tests parameter:
- Concentration of HCl solution ranged between 1-7 N,
- Hydrolysis temperature ranged between 35-95 °C, and
- The time of hydroly
Nisoldipine (NSD) is a dihydropyridine class of calcium channel blockers used for hypertension treatment, it belongs to class II BCS (low solubility with high permeability), its absolute bioavailability is only 5% due to presystemic metabolism in the gut wall. It is also a substrate for a CYP3A and P-gp. Bilosomes are lipid bilayer vesicles incorporating bile salts in their walls to prevent degredation by GIT bile salts. The aim of this study is to prepare nisoldipine bilosomes as vesicular carrier and assess the effect of different formulation variables such as type of surfactant, amount of cholesterol, surfactant and sonication time on particle size, entrapment efficiency and poly dispersity index of the prepared bilos
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Toxoplasmosis is a widespread infection usually caused by Toxoplasma gondii (T. gondii) parasite. It occurs in humans and other warm blooded animals, causing severe problems. It was found that there is an alteration in the trace elements concentrations levels associated with some human diseases. This study aimed to investigate the changes in the concentrations of some trace elements (Mg, Fe , Zn, and Cu) in the sera of 60 immunocompetent patients with chronic toxoplasmosis and 82 healthy individuals as a control group. Measuring the serum level of seropositivity rate of anti-T. gondii antibodies was done by Enzyme Linked Immunosorbent Assay (ELISA) Kit, while the concentrations of trace elements were measured by absorption spectrophotometry
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KE Sharquie, MM Al-Waiz, AA Noaimi, Iraqi Postgraduate Medical Journal, 2008 - Cited by 1
Background: migraine is a chronic neurovascular disorder characterized by intermittent attacks of sever headache with or without aura that can include various combinations of neurological, gastrointestinal tract (G.I.T), and autonomic changes, without evidence of primary structural abnormalities. The Autonomic nervous system involvement suggested by many symptoms and signs including nausea, diarrhea, constipation, coldness in the extremities, paroxysmal tachycardia and chest pain.
Objectives: To evaluate autonomic functions in patients with migraine and to clarify the autonomic dysfunction weather its sympathetic, parasympathetic, or combined. Also to assess the severity of this dysfunction and its relation to age, gender and type of
Background: The estimation of ferritin and related variables by complete serum iron profile, for Iraqi hashimoto’s patients to see the effect of thyroid hormone insufficiency, which may lead to deficiency of ferritin iron stores, this may be quite useful during the diagnosis and treatment of hashimoto’s patients. Patients and Method: The study was performed at National Center of Teaching laboratories of Medical city institute in Baghdad. Fifty newly diagnosed patients with hashimoto’s and forty apparently healthy controls. Diagnosis based on thyroid profile analysis including:Thyroid Stimulating Hormone (TSH), Thyroxine (totalT4) and Triiodothyronine (total T3), estimation of antibodies against thyroperoxidase, iron profile including:
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Osteoarthritis is the most prevalent arthritic disease and a leading cause of disability. The pathogenesis of osteoarthritis involves multiple etiologies, including variable degree of synovial inflammation. Metformin and pioglitazone could potentially reduce the levels and activity of inflammatory mediators. This may consider as a new therapeutic approach added to the current used drugs in an attempt to decrease the pain, inflammation, and improve daily activity and quality of life in patients with knee osteoarthritis.
This study designed to evaluate the clinical utility of using metformin or pioglitazone as anti-inflammatory agents in combination with non-steroidal anti-inflammatory drugs (NSAID) of selective type of cyclooxygen
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