Background: Oral Lichen Planus is a chronic inflammatory mucosal disease, presenting in various clinical forms .Both antigen-specific and non-specific mechanisms involved in the pathogenesis of OLP. Apoptosis or programmed-cell death is a physiological process essential for the normal development and maintenance of homeostasis in many organisms. Fas is a cell-surface glycoprotein, 40-kDa, that belongs to the nerve growth factor / tumor necrosis factor (TNF) receptor family. Fas is expressed in several tissues including blood, where its expression is upregulated on activated T and B lymphocytes and natural killer cells. Fas ligand is a type II transmembrane protein that belongs to the tumor necrosis factor family. The proto-oncogene c-Myc is a transcripation factor with roles in cellular proliferation, differentiation, apoptosis and cell cycle progression. Mutation in the c-Myc gene and protein over-expression has been associated with a variety of hematopoietic tumors, leukemias and lymphomas. Apoptosis is the mechanism that would be dysregulated in this disease. This study was conducted to evaluate the expression of Fas, Fasl and c-Myc in oral lichen planus and to correlate the expression of either markers with each other. Materials and Methods: This study was performed on thirty formalin- fixed paraffin-embedded tissue blocks of oral lichen planus pro and retrospectively. An immunohistochemical staining was done by using monoclonal antibodies for Fas, Fasl and c-Myc. Results: Expressions of Fas, Fasl and c-Myc were highly detected in keratinocytes and inflammatory cells of OLP cases compared to negative expression in normal oral mucosa. Significant correlation has been found between expression of Fas, Fasl and c-Myc in epithelial cells with that of inflammatory cells in oral lichen planus studied cases. Significant correlation has been found among expressions of Fas, Fasl and c-Myc in epithelial cells of oral lichen planus cases. Significant positive correlation found between expressions of Fas, Fasl and c-Myc in keratinocytes and inflammatory cells of oral lichen planus . Conclusion: Increased expression level of Fas, Fasl and c-Myc in both keratinocytes and lymphocytes of OLP cases in comparison to normal mucosa with highly significant correlation among the markers expression indicate their important role in malignant transformation of oral lichen planus.
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Our research subject (environmental impact in the cultural output of the civilizations of ancient East) the environmental impact on human civilization and how her and adapted to serve in various cultural aspects especially in ancient cultures whether punches or sculptures and other addresses as well as tracing precious stones and raw materials. It was the environment of the civilizations of Mesopotamia and Egypt and another effective impact in drawing ancient history through human interaction and responsiveness. The Iraqi environment was marked by poverty and cruelty on the one hand and on the other cultural elements contributed to the civilization in General and research dealing with technical and product sourcing raw materi
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Sought the search to find out what small businesses, the importance of funding, and the role of funders in supporting such projects, which have been addressed in the search through a sample of government banks (Rafidain and Rasheed) and private banks (the Middle East, the Gulf, North, Assyria) and a sample of Small projects borrowed from these banks, but in order to achieve that rely researchers on scientific methods discreet marked by the curriculum descriptive analytical method which is based on the compilation of facts and information then collated and analyzed to reach acceptable results, as well as data collection tool (checklist) was whereby examine questions of a sample of
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Benign prostatic hyperplasia (BPH) is one of the most common disease and major cause of morbidity in elderly men which may lead to bladder outflow obstruction and lower urinary tract symptoms (LUTS). Although sex steroid hormones play fundamental roles in prostate growth, their clinical significance is not completely clear. In the present study we assessed whether serum hormones levels as markers of prostate disease. This study includes (40) patients with benign prostatic hypertrophy and (40) control group with age rang (41-79) and (42-71) years respectively. The following biochemical investigations have been studied: Testosterone, Estradiol (E2), and Prostatic Specific Antigen (PSA) levels using ELISA method which correlated with t
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